Genetic Variation in the HR Region of the<i>env</i>Gene of HIV: A Perspective for Resistance to HIV Fusion Inhibitors

Qadir, Muhammad Imran; Malik, Salman Akbar

doi:10.1089/aid.2010.0098

Cited by 12 publications

(2 citation statements)

References 22 publications

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“…Now a days, many drugs in-use have become resistant and there is a dire need for the search and development of new drugs [9,10]. Natural products are being considered a good source of new therapeutic agents [11,12].…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic Effect of Ethanol Extract of Convolvulus arvensis L (Convolvulaceae) on Lymphoblastic Leukemia Jurkat Cells

Saleem¹,

Qadir²,

Ahmad³

et al. 2014

Trop. J. Pharm Res

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of the extract to determine cell viability, cell proliferation, apoptosis using Trypan blue exclusion assay, 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay and fluorescent activated cell sorter (FACS) analysis, respectively. Results: Trypan blue exclusion assay and MTS assay results indicate that the ethanol extract decreased the number of living cells in a concentration-dependent fashion. The results of FACS analysis showed that the lowest concentration of the extract (10 µg/mL) was most effective for the induction of apoptosis as it induced maximum apoptosis (85.34 %) and the highest concentration (100 µg/mL) was less effective as it induced less apoptosis (53.70 %) in Jurkat cells (p < 0.05). Conclusion:The ethanol extract of C. arvensis has significant cytotoxic activity against the selected cancer cell line. Furthermore, apoptotic effect was more prominent at lower doses and necrosis at higher doses of the extract.

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Section: Discussionmentioning

confidence: 99%

Cytotoxic Effect of Ethanol Extract of Convolvulus arvensis L (Convolvulaceae) on Lymphoblastic Leukemia Jurkat Cells

Saleem¹,

Qadir²,

Ahmad³

et al. 2014

Trop. J. Pharm Res

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“…With the highly active ART introduction, there is a reduction in the chances of opportunistic infections and mortality in patients having HIV infection. But at the same time, morbidity and mortality in such individuals has been increased due to the liver complications and HCV infection …”

Section: Hcv‐hiv Coinfectionmentioning

confidence: 99%

Hepatitis in AIDS patients

Qadir

2017

Reviews in Medical Virology

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SummaryThe individuals with HIV infection are more susceptible to develop coinfections with infectious pathogens such as HCV and HBV. The routes of transmission of these pathogens are the same including sexual contact, injection drug use, or at birth from mother to an infant. The main reason of morbidity and mortality in HIV infected individuals is a liver disease in the context of antiretroviral therapy, and coinfection such as HCV and HBV complicates this condition. Nucleos(t)ide analogues are used for HBV infection management, and treatment of HCV infection is done by PegIFN and ribavirin combination and protease inhibitors. In this review, we focused on hepatitis B and C infections in HIV patients along with their therapies.

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