Genetic variation in the response of mice to total body x‐irradiation. I. Body weight response of six inbred strains

Effects of Neonatal Irradiation and Genotype on Postnatal Growth in Mice

“…Genetic control over body and organ weights was evidenced in the significant effects on body weight at each of the weekly intervals due to sex, line of sire, line of dam, and the interaction of line of sire with line o f dam. The sex differences in body weight in the mouse has been observed in numerous other studies including G ra h n [1]; N ash and G ow en [9]; S h iba ta [12]; N a sh [7]; K id w e l l and H ow ard [4]. The significant sex differences in organ weight: body weight ratios observed for the heart, spleen, and kidney, confirm the results observed by N ash [8] utilizing the same genotypes of mice.…”

“…However, other studies show that, in general, there is a decline in radiation sensitivity, as measured by changes in body weight, with increasing age between birth and sexual maturity. G r a h n [1], for example, studied growth response in inbred strains of mice following irradiation at 40 days of age. Calculations of regressions from his data revealed that the regression of body weight on dosage at 60 days of age was -0.0016 g/r in the dose range of 0-400 r.…”

Effects of Postirradiation Surgical Stress, Anesthesia, and Spleen Transplantation on Survival of Mice

“…The important sequelae, however, may result from the ensuing inflammatory reaction and the fever. 7 Ether anesthesia may act either by depressing or by reversing some recovery processes at a very critical time, or there may be some substance in the ether (possibly the ether itself) which potentiates the deleterious action of radiationinduced substances. Anesthesia of otherwise untreated mice resulted in no deaths.…”

Volitional activity of inbred and hybrid mice as influenced by x-radiation

“…Inbred mice were from strain S and strain BALB/Gw (henceforth referred to as Ba). These strains have been found to be least susceptible and most susceptible to X-radiation, respectively, In regard to factors such as lethality (Stadler and Gowen, 1957) and body weight changes (Grahn, 1954) (Figure 1). 2964 revolutions of the wheel equal a distance of one mile.…”