Genetic variation in the serotonin transporter gene influences ERP old/new effects during recognition memory

Ross, Robert S.; Medrano, Paolo; Boyle, Kaitlin; Smolen, Andrew; Curran, Tim; Nyhus, Erika

doi:10.1016/j.neuropsychologia.2015.09.028

Cited by 12 publications

(20 citation statements)

References 76 publications

(155 reference statements)

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“…Groups of electrodes were averaged together to form regions of interest (ROI; Figure ), similar to what has been done by other researchers (Ally & Budson, ; Norman, Tepe, Nyhus, & Curran, ; Ross et al., ). Our analyses were focused on the left anterior superior (LAS), right anterior superior (RAS), left posterior superior (LPS), right posterior superior (RPS), and right fronto‐polar (RFP) ROIs.…”

Section: Methodsmentioning

confidence: 99%

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Individual differences in EEG correlates of recognition memory due to DAT polymorphisms

et al. 2017

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IntroductionAlthough previous research suggests that genetic variation in dopaminergic genes may affect recognition memory, the role dopamine transporter expression may have on the behavioral and EEG correlates of recognition memory has not been well established.ObjectivesThe study aims to reveal how individual differences in dopaminergic functioning due to genetic variations in the dopamine transporter gene influences behavioral and EEG correlates of recognition memory.MethodsFifty‐eight participants performed an item recognition task. Participants were asked to retrieve 200 previously presented words while brain activity was recorded with EEG. Regions of interest were established in scalp locations associated with recognition memory. Mean ERP amplitudes and event‐related spectral perturbations when correctly remembering old items (hits) and recognizing new items (correct rejections) were compared as a function of dopamine transporter group.ResultsParticipants in the dopamine transporter group that codes for increased dopamine transporter expression (10/10 homozygotes) display slower reaction times compared to participants in the dopamine transporter group associated with the expression of fewer dopamine transporters (9R‐carriers). 10/10 homozygotes further displayed differences in ERP and oscillatory activity compared to 9R‐carriers. 10/10 homozygotes fail to display the left parietal old/new effect, an ERP signature of recognition memory associated with the amount of information retrieved. 10/10 homozygotes also displayed greater decreases of alpha and beta oscillatory activity during item memory retrieval compared to 9R‐carriers.ConclusionCompared to 9R‐carriers, 10/10 homozygotes display slower hit and correct rejection reaction times, an absence of the left parietal old/new effect, and greater decreases in alpha and beta oscillatory activity during recognition memory. These results suggest that dopamine transporter polymorphisms influence recognition memory.

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Section: Methodsmentioning

confidence: 99%

“…Groups of electrodes were averaged together to form regions of interest (ROI; Figure 2), similar to what has been done by other researchers (Ally & Budson, 2007;Norman, Tepe, Nyhus, & Curran, 2008;Ross et al, 2015). Our analyses were focused on the left anterior superior & Piatt, 2006;Norman et al, 2008;Rugg et al, 1998)…”

Section: Erp Regions Of Interestmentioning

confidence: 99%

Individual differences in EEG correlates of recognition memory due to DAT polymorphisms

et al. 2017

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“…Participants for the study were recruited from the University of Colorado Boulder community. Data from these same participants examining how the 5HTTLPR serotonin transporter polymorphism affects ERP’s and how dopamine transporter polymorphisms affect ERP’s and oscillatory power during recognition memory has been reported elsewhere (Ross et al, 2015 ; Medrano et al, 2017 ). Participants were given monetary compensation for their participation.…”

Section: Methodsmentioning

confidence: 97%

“…We analyzed the item and source data using groupings of seven electrodes for different scalp locations (regions of interest, ROIs) within specific timeframes (Figure 2 ), similar to our past approach (Norman et al, 2008 ; Nyhus and Curran, 2009 ; Ross et al, 2015 ). We examined four ROIs and three time frames due to their relevance to ERP effects related to recognition memory.…”

Section: Methodsmentioning

confidence: 99%

“…Personalized treatment for cognitive disruptions related to mental disorders relies on developing an understanding of individual differences in cognition. Genetic variation may be one component driving individual differences in cognitive ability (Friedman et al, 2008 ; Stelzel et al, 2010 ; Barnett et al, 2011 ; Markett et al, 2011 ; van Holstein et al, 2011 ; Colzato et al, 2013a , b ; Ross et al, 2015 ). One gene that has been linked to symptoms of mental disorders, such as depression (Dannlowski et al, 2009 ) and anxiety (Tadic et al, 2003 ) as well as cognitive abilities, including episodic memory (Mueller et al, 2014 ), is the monoamine oxidase A gene ( MAO-A ).…”

Section: Introductionmentioning

confidence: 99%

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MAO-A Phenotype Effects Response Sensitivity and the Parietal Old/New Effect during Recognition Memory

Ross

Smolen

Curran

et al. 2018

Front. Hum. Neurosci.

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A critical problem for developing personalized treatment plans for cognitive disruptions is the lack of understanding how individual differences influence cognition. Recognition memory is one cognitive ability that varies from person to person and that variation may be related to different genetic phenotypes. One gene that may impact recognition memory is the monoamine oxidase A gene (MAO-A), which influences the transcription rate of MAO-A. Examination of how MAO-A phenotypes impact behavioral and event-related potentials (ERPs) correlates of recognition memory may help explain individual differences in recognition memory performance. Therefore, the current study uses electroencephalography (EEG) in combination with genetic phenotyping of the MAO-A gene to determine how well-characterized ERP components of recognition memory, the early frontal old/new effect, left parietal old/new effect, late frontal old/new effect, and the late posterior negativity (LPN) are impacted by MAO-A phenotype during item and source memory. Our results show that individuals with the MAO-A phenotype leading to increased transcription have lower response sensitivity during both item and source memory. Additionally, during item memory the left parietal old/new effect is not present due to increased ERP amplitude for correct rejections. The results suggest that MAO-A phenotype changes EEG correlates of recognition memory and influences how well individuals differentiate between old and new items.

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Exploring the Event‐Related Potentials' Time Course of Associative Recognition in Autism

et al. 2020

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Behavioral data on episodic recollection in autism spectrum disorders (ASD) point limited relational memory functioning. However, the involvement of successive memory processes in the profile of episodic memory in ASD needs more study. Here, we used event-related potentials (ERP) to investigate the time course of episodic recollection with an associative recognition paradigm with picture pairs. Twenty-two participants with ASD and 32 with typical development (TD), all right-handed, were included. Behavioral results confirmed difficulties in correctly recognizing identical pairs in the ASD relative to TD group. We found an unexpected amplitude decrement on the P2 (220-270 msec) and FN400 (350-470 msec) potentials, suggesting diminished priming and familiarity effects in the ASD relative to TD group. However, ERP data revealed that the recognition of associative information relies on the same electrophysiological process (old/new effect in the 600-700-msec late positive component) in ASD participants as in TD ones, with a parietal extension in the ASD group. These results suggest that the electrophysiological processes of associative recognition are qualitatively similar in individuals with and without ASD but may differ quantitatively. This difference may be driven by the reduced early processing of picture pairs that may in turn lead to their diminished integration into the semantic memory system, being partially compensated by a greater involvement of associative memory during the recollection process. Other studies would be useful to go further in identifying these cognitive processes involved in atypical recognition in ASD and their neural substrates.

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Genetic variation in the serotonin transporter gene influences ERP old/new effects during recognition memory

Cited by 12 publications

References 76 publications

Individual differences in EEG correlates of recognition memory due to DAT polymorphisms

Individual differences in EEG correlates of recognition memory due to DAT polymorphisms

MAO-A Phenotype Effects Response Sensitivity and the Parietal Old/New Effect during Recognition Memory

Exploring the Event‐Related Potentials' Time Course of Associative Recognition in Autism

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