Genetic variation of wild Puumala viruses within the serotype, local rodent populations and individual animal

Plyusnin, Alexander; Vapalahti, Olli; Lehväslaiho, Heikki; Apekina, N. S.; Mikhailova, Tatiana; Gavrilovskaya, Irina N.; Laakkonen, Juha; Niemimaa, Jukka; Henttonen, Heikki; Brummer-Korvenkontio, M; Vaeri, Antti

doi:10.1016/0168-1702(95)00038-r

Cited by 76 publications

(79 citation statements)

References 36 publications

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“…16 These data were also consistent with the geographic-specific lineages shown previously for rodent-borne hantaviruses, including HTNV in Apodemus agrarius , 26 Soochong virus in Apodemus peninsulae , 27 Puumala virus in Myodes glareolus , 28,29 Muju virus in Myodes regulus , 30 and Tula virus in Microtus arvalis . 31 Overall, these data were suggestive of long-standing associations between hantaviruses and their reservoir rodent and soricid hosts, but the basis for these relationships through evolutionary time is unclear.…”

supporting

confidence: 77%

Genetic Diversity of Thottapalayam Virus, a Hantavirus Harbored by the Asian House Shrew (Suncus murinus) in Nepal

Kang¹,

Kosoy²,

Shrestha³

et al. 2011

The American Society of Tropical Medicine and Hygiene

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Abstract. Despite the recent discovery of genetically divergent hantaviruses in shrews of multiple species in widely separated geographic regions, data are unavailable about the genetic diversity and phylogeography of Thottapalayam virus (TPMV), a hantavirus originally isolated from an Asian house shrew ( Suncus murinus ) captured in southern India more than four decades ago. To bridge this knowledge gap, the S, M, and L segments of hantavirus RNA were amplified by reverse transcription polymerase chain reaction from archival lung tissues of Asian house shrews captured in Nepal from January to September 1996. Pair-wise alignment and comparison revealed approximately 80% nucleotide and > 94% amino acid sequence similarity to prototype TPMV. Phylogenetic analyses, generated by maximum likelihood and Bayesian methods, showed geographic-specific clustering of TPMV, similar to that observed for rodent-and soricid-borne hantaviruses. These findings confirm that the Asian house shrew is the natural reservoir of TPMV and suggest a longstanding virus-host relationship.

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supporting

confidence: 77%

Genetic Diversity of Thottapalayam Virus, a Hantavirus Harbored by the Asian House Shrew (Suncus murinus) in Nepal

Kang¹,

Kosoy²,

Shrestha³

et al. 2011

The American Society of Tropical Medicine and Hygiene

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“…According to a proposed theory (Plyusnin et al, 1995), the extent of hantavirus diversity is proportional to the geographic distance between areas of their circulation. However, while the microgeographical relationships among hantaviruses might be linearly proportional, the macrogeographical relationships are probably more complex.…”

Section: Discussionmentioning

confidence: 99%

Genetic similarity of Puumala viruses found in Finland and western Siberia and of the mitochondrial DNA of their rodent hosts suggests a common evolutionary origin

Dekonenko

Yakimenko

Ivanov

et al. 2003

Infection, Genetics and Evolution

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“…According to a theory proposed by Plyusnin et al [30,31], the extent of hantavirus diversity is proportional to the geographic distance between the areas of their circulation. However, while the microgeographical relationships among hantaviruses might be linearly proportional, the macrogeographical relationships are likely to be more complex.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological Study of Hantavirus Infection in the Samara Region of European Russia

et al. 2009

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ABSTRACT. European Russia is a highly endemic area of hemorrhagic fever with renal syndrome (HFRS), a rodent-borne zoonotic disease, caused by hantaviruses. In total, 145 small mammals of four species (Myodes glareolus, Apodemus flavicollis, A. agrarius, and A. uralensis) were trapped in the Samara region of European Russia in August 2005 and examined for the presence of hantavirus (HV). Anti-HV antibodies were found in six of 68 (8.8%) M. glareolus and in one of 19 (5.3%) A. flavicollis by indirect immunofluorescent antibody assay (IFA). The Puumala virus (PUUV), which is one of the hantavirus species, was detected in the lungs of seven M. glareolus by RT-PCR. The virus S-segment was extremely similar (96.2% to 99.3%) to the sequence found in a fatal case of HFRS in the Samara region. Phylogenetic analyses of S and M segments showed that the Samara PUUVs form a cluster within the Russian Volga lineage and apparently differ from other European PUUVs. Anti-PUUV antibodies were found in blood sera from seven HFRS patients and from one undiagnosed patient from the Samara region, using IFA and an enzyme-linked immunosorbent assay (ELISA). These data suggest that the bank vole M. glareolus is a primary natural reservoir and vector for PUUV, which is the main causative agent of HFRS in humans in the Samara region.KEY WORDS: epidemiology, hantavirus, hemorrhagic fever with renal syndrome, Puumala virus, rodents.J. Vet. Med. Sci. 71(12): 1569-1578, 2009 Hantaviruses belong to the genus Hantavirus, within the family Bunyaviridae, and cause two forms of human illness. These zoonoses include hemorrhagic fever with renal syndrome (HFRS), which occurs in Asia and Europe and is caused by the Hantaan virus (HTNV), Seoul virus (SEOV), Puumala virus (PUUV), Dobrava-Belgrade virus (DOBV), and Amur virus (AMRV). The second form of illness is hantavirus (cardio) pulmonary syndrome (HPS), which occurs in the Americas and is caused by the Sin Nombre virus, Andes virus, and other hantaviruses [13,28,33]. Hantaviruses are transmitted by aerosolized excreta from their natural hosts, mainly rodents of the family Muridae. Particular hantavirus species are usually harbored by a single rodent species, or by a few closely related rodent species, which indicates co-evolution and co-speciation of hantaviruses with their hosts. The virus genome contains three segments of negative-stranded RNA: the large (L) segment encodes a viral RNA-dependent RNA polymerase, the medium (M) segment encodes a glycoprotein precursor, and the small (S) segment encodes a nucleocapsid protein (NP) [34].In

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Genetic variation of wild Puumala viruses within the serotype, local rodent populations and individual animal

Cited by 76 publications

References 36 publications

Genetic Diversity of Thottapalayam Virus, a Hantavirus Harbored by the Asian House Shrew (Suncus murinus) in Nepal

Genetic Diversity of Thottapalayam Virus, a Hantavirus Harbored by the Asian House Shrew (Suncus murinus) in Nepal

Genetic similarity of Puumala viruses found in Finland and western Siberia and of the mitochondrial DNA of their rodent hosts suggests a common evolutionary origin

Epidemiological Study of Hantavirus Infection in the Samara Region of European Russia

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