Genetic variations are associated with lymph node metastasis in colorectal cancer patients

Lan, Yuan Tzu; Yang, Shung Haur; Lin, Jen Kou; Lin, Chun Chi; Wang, Huann Sheng; Chen, Wei Shone; Lin, Tzu Chen; Jiang, Jeng Kai; Chang, Shih Ching

doi:10.1002/jso.23613

Cited by 7 publications

(8 citation statements)

References 45 publications

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“…Furthermore, many SNP-associated genes were also associated with adhesion-and immune-related signaling pathways, including adherens junction, chemokine signaling pathway, and cytokine-cytokine receptor interaction [26]. Otherwise, Lan and colleagues demonstrated that genetic polymorphisms of insulin-like growth factor 1 (IGF-1) and interleukin-8 (IL-8) increased susceptibility to lymph node metastasis in CRC patients [27]. All these data suggested that the polymorphisms of those immunerelated genes play an important role in the metastasis of CRC.…”

Section: Discussionmentioning

confidence: 99%

The Role of Formyl Peptide Receptor 1 Gene Polymorphisms in Human Colorectal Cancer

Zhang

et al. 2020

J. Cancer

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Formyl peptide receptor 1 (FPR1) belongs to G protein-coupled receptors expressed mainly in phagocytic leukocytes. The gene encoding FPR1 is highly polymorphic and related to inflammation. In this study, we investigated the single nucleotide polymorphisms (SNPs) of Fpr1 in human colorectal cancer (CRC), and analyzed the association of Fpr1 SNPs with clinicopathological parameters and some specific diagnostic markers of CRC. Although the allele and genotype frequencies of Fpr1 SNPs in CRC tissues were not significantly different from that in whole blood cells derived from healthy Chinese subjects. Significant associations were observed between genotypes of c.289C>A and distant metastasis (P=0.001), and between genotypes of c.306T>C and tumor size (P=0.016). Genotypes of c.546C>A was closer to tumor size and lymphatic invasion (P=0.012 and P=0.043, respectively). Meanwhile, genotypes of c.1037C>A was related with tumor location and differentiation (P=0.000 and P=0.005, respectively). Besides, genotypes of c.576T>C>G was related with pathological type (P=0.000). Furthermore, several Fpr1 SNP positions including c.289 (C>A) and c.576 (G>C>T) were related to the expression of P53 (P=0.004 and P=0.008, respectively), and similar results were observed between other Fpr1 SNP positions and CEA, HER2 and Ki-67 (P<0.05). Our data demonstrate that Fpr1 SNPs may play the important role in the progression and metastasis of CRC.

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Section: Discussionmentioning

confidence: 99%

The Role of Formyl Peptide Receptor 1 Gene Polymorphisms in Human Colorectal Cancer

Zhang

et al. 2020

J. Cancer

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“…In total, 1475 CRC patients underwent surgery at the Taipei Veterans General Hospital from 2000 to 2010 (Approval by the Institutional Review Board of Taipei Veterans General Hospital (number 2013-04-042B) [ 40 , 41 , 42 ]. Exclusion criteria were preoperative radio chemotherapy, emergency operations, or death within 30 days of surgery.…”

Section: Methodsmentioning

confidence: 99%

Molecular and Clinicopathological Differences by Age at the Diagnosis of Colorectal Cancer

Chang

Lin

et al. 2017

IJMS

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We compared the clinicopathological and molecular profiles between different age groups of sporadic colorectal cancer (CRC) patients (age <50, 56–60, 60–70, 70–80, and >80); 1475 CRC patients were enrolled after excluding 30 individuals with Lynch syndrome. The mutation spectra for APC, TP53, KRAS, PIK3CA, FBXW7, BRAF, NRAS, HRAS, TGFbR, Akt1, and PTEN were analyzed using polymerase chain reaction (PCR), followed by MassArray and microsatellite (MSI-high) analysis by performing genotyping. Male patients (74.1%) were significantly predominant to females (25.9%) in the older age group (70–80, >80). There was an insignificantly linear trend between TNM staging and age-onset of CRC diagnosis. Patients aged < 50 had 58.7% diseases in the advanced stages (Stage III: 36.5% and IV: 22.2% respectively), while this decreased to 40.2% (Stage III: 26.2% and IV; 14.0% respectively) in patients >80. The distributions of mutation frequency were similar in majority of the genes studied among different age groups. Additionally, patients aged <50 had significantly higher frequency of MSI-high, PTEN, and HRAS mutations than those of other groups. Age-onset at diagnosis significantly affected overall survival (HR = 1.46; 95% CI: 1.35–1.58), but not cancer-specific survival (HR = 1.08; 95% CI: 0.99–1.18) in multivariate analysis. In conclusion, molecular and clinicopathological differences were not as significant among different age groups of CRC patients as previously suspected.

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“…Similarly, Lan et al examined 629 patient colorectal cancer samples for genetic factors that can help distinguish LN status [31]. Rather than genes, however, the authors of this study looked for single nucleotide polymorphisms (SNPs) in the genome.…”

Section: Drivers and Predictors Of Ln Metastasismentioning

confidence: 99%

Biology of Nodal Spread in Colon Cancer: Insights from Molecular and Genetic Studies

2018

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Colorectal cancer (CRC) lymph node metastases are common but their genetics and the mechanism whereby these metastases occur are not well understood. Here we present recent data regarding genetic heterogeneity in primary CRCs and their metastasis. In addition, we explain the different potential models describing the mechanisms of metastasis and the data supporting them. Multiple studies have also revealed a variety of prognostic molecular markers that are associated with lymph node metastasis in CRC. A better understanding of genetic heterogeneity and the mechanisms of metastasis is critical to predicting clinical response and resistance to targeted therapy.

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Genetic variations are associated with lymph node metastasis in colorectal cancer patients

Abstract: Certain SNPs can increase genetic susceptibility to LN metastasis. As the number of risk alleles increases, the risk of LN metastasis also increases, although the difference is subtle.

Cited by 7 publications

References 45 publications

The Role of Formyl Peptide Receptor 1 Gene Polymorphisms in Human Colorectal Cancer

The Role of Formyl Peptide Receptor 1 Gene Polymorphisms in Human Colorectal Cancer

Molecular and Clinicopathological Differences by Age at the Diagnosis of Colorectal Cancer

Biology of Nodal Spread in Colon Cancer: Insights from Molecular and Genetic Studies

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