Genetic Variations in Tumor Necrosis Factor Alpha, Interleukin-10 Genes, and Migraine Susceptibility

Ateş, Ömer; Kurt, Semiha; Altınışık, Jülide; Karaer, Hatice; Sezer, Saime

doi:10.1111/j.1526-4637.2011.01200.x

Cited by 22 publications

(15 citation statements)

References 33 publications

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“…Migraine Type/Features Action in Relation to Migraine Dopamine type 2 (D2) receptor 23 Migraine with and without aura 23,91 • Vasoconstriction • Reduces trigeminal nerve activation • Inhibits release of vasoactive neuropeptide • Interrupts pain transmission centrally Glutathione S-transferase 92 Migraine without aura 92 • Increases susceptibility to environmental xenobioticinduced migraine attacks in GSTM1 genotype Dopamine type 4 (D4) receptor 93 Migraine without aura 93 • A potential genetic association exists between dopamine D4 receptor gene and migraine without aura Tumor necrosis factor-a 94 Migraine without aura 95 • Proinflammatory cytokine Methyltetrahydrofolate reductase (MTHFR) C677T allele 96 Migraine with aura 96 • MTHFR C677T polymorphism may increase homocysteine levels associated with migraine with aura Dopamine b-hydroxylase gene 97 Migraine with aura 97 • An intracellular enzyme catalyzing the conversion of dopamine to noradrenaline; imbalance may increase susceptibility to migraine Angiotensin-converting enzyme allele 98 Migraine with and without aura 90,99,100 • Involved in vasoconstriction and vascular remodeling…”

Section: Gene Productmentioning

confidence: 99%

Biomarkers Associated With Migraine and Their Potential Role in Migraine Management

Durham

Papapetropoulos

2013

Headache

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The understanding of the etiology of migraine is incomplete. Although the identification and validation of biomarkers has greatly advanced diagnostic precision and measures of therapeutic efficacy in other diseases, there are no currently accepted biomarkers for chronic or episodic migraine. However, the continued investigation and identification of genetic, epigenetic, and molecular biomarkers is likely to facilitate the goal of individualizing medicine by enabling clinicians to more accurately diagnose and treat migraine and other headache disorders.

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Section: Gene Productmentioning

confidence: 99%

Biomarkers Associated With Migraine and Their Potential Role in Migraine Management

Durham

Papapetropoulos

2013

Headache

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“…The genotype distribution of the included studies and the P-values for HWE testing are shown in Tables I and II. Main results, subgroup analyses. Six studies concerning the correlation between the TNF-α -308G/A polymorphism and migraine are shown in Table I (14) and Ghosh et al (15) revealed a significant association between the TNF-α -308G/A polymorphism and migraine risk. However, Hasan et al (16) revealed no significant association between the polymorphism and migraine and the results of Lee et al (17) were uncertain.…”

Section: Study Inclusion and Characteristicsmentioning

confidence: 99%

“…In addition, among the included studies, one concerned only MO (12) and another only MA (13), three (15)(16)(17) clarified the clinical type of migraine and one (14) did not clarify the clinical type.…”

Section: Study Inclusion and Characteristicsmentioning

confidence: 99%

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The TNF-α-308G/A polymorphism is associated with migraine risk: A meta-analysis

Gu¹,

Yan²,

Long

et al. 2012

Experimental and Therapeutic Medicine

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Abstract. Migraine is a neurasthenia and the genetic etiology has not been determined. Several studies concerning the correlation between the tumor necrosis factor (TNF)-α -308G/A polymorphism and migraine have been published, but their results remain controversial and the small samples in each study do not allow sufficient statistical power. In the present study, odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the association between the polymorphism and migraine. An inverse-variance method was applied to estimate the frequency of the putative risk allele in the controls. Heterogeneity was determined using Cochran's Q test and the inconsistency index (I 2 ). Begg's test and the inverted funnel plot were used to assess the publication bias. Five studies on Asian populations, comprising 985 cases and 958 controls, were included in the meta-analysis. The overall results revealed that the TNF-α -308G/A polymorphism was associated with migraine risk in Asians. The ORs were 1.735 (95% CI, 1.129-2.666) for A vs. G; 1.781 (95% CI, 1.166-2.718) for GA vs. GG; 1.821 (95% CI, 1.153-2.874) for AA+GA vs. GG. The subgroup analysis was based on migraine with aura (MA) and migraine without aura (MO) and there was a statistically significant result for MA [the OR was 1.728 (95% CI, 1.095-2.726) for GA vs. GG and 1.651 (95% CI, 1.049-2.598) for AA+GA vs. GG] but not for MO. In conclusion, the TNF-α -308G/A polymorphism was associated with migraine risk. IntroductionMigraine is a common, chronic, recurrent and neurovascular disorder which is associated with digestive system and autonomic nervous system symptoms (1). The two main clinical types are MA (migraine with aura) and MO (migraine without aura). In the general population, 10% of males and 24% of females suffer from migraine (2,3). A review (4) reported that the global incidence of adult migraine is over 10%. It has been confirmed that migraine is associated with other diseases. Research has shown that MA may increase the risk of cardiovascular disease (CVD), myocardial infarction and ischemic stroke in female patients (5). The mortality rate of patients with MA who have CVD and stroke is higher than that of those who do not suffer from migraine (6).However, the pathophysiology of migraine remains unclear. Previously, the vascular hypothesis (7) proposed that migraine was caused by intracranial and extracranial vascular dysfunction. However, this hypothesis did not address neurogenic changes and did not explain the typical migraine (MA) and common migraine (MO) phenomena. Neurogenic inflammation may be a key mechanism in stimulating the trigeminal system and causing the headache.Tumor necrosis factor (TNF) is a pro-inflammatory molecule and a polypeptide effector of the inflammatory reaction which also appears to play a role in migraine. TNF-α activates the transcription of calcitonin gene-related peptide (CGRP) and plays a key role in migraine pathophysiology (8). A study (9) revealed that levels of CGRP in the external jugular vei...

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“…The study group consisted of 203 patients with migraine (25 male and 178 female; mean age: 36.49 ± 9.55 standard deviation [SD] years), and 202 (28 male and 174 female; mean age: 38.18 ± 8.42 SD years) healthy subjects who had taken part in our previous study [35]. All migraine patients were registered at the outpatient clinic of the Neurology Department at Gaziosmanpasa Medical Faculty, and they all fulfilled the International Headache Society criteria for classification [1].…”

Section: Subjectsmentioning

confidence: 99%

Genetic association of 5-HT1A and 5-HT1B gene polymorphisms with migraine in a Turkish population

Ateş

Karakuş

Sezer

et al. 2013

Journal of the Neurological Sciences

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Genetic Variations in Tumor Necrosis Factor Alpha, Interleukin-10 Genes, and Migraine Susceptibility

Abstract: This study reflect that TNF-α-308G/A polymorphism may be one of the many genetic factors for migraine susceptibility in the Turkish population.

Cited by 22 publications

References 33 publications

Biomarkers Associated With Migraine and Their Potential Role in Migraine Management

Biomarkers Associated With Migraine and Their Potential Role in Migraine Management

The TNF-α-308G/A polymorphism is associated with migraine risk: A meta-analysis

Genetic association of 5-HT1A and 5-HT1B gene polymorphisms with migraine in a Turkish population

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