Genetic variations in vascular endothelial growth factor but not in angiotensin I-converting enzyme genes are associated with endometriosis in Estonian women

Lamp, Merit; Saare, Merli; Laisk, Triin; Karro, Helle; Kadastik, Ülle; Metspalu, Andres; Peters, Maire; Salumets, Andres

doi:10.1016/j.ejogrb.2010.07.021

Cited by 26 publications

(47 citation statements)

References 32 publications

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“…A contribution of the VEGF -2578 A/C SNP to endometriosis was also observed in the Estonian population, as well as VEGF -460/-1154/-2578 TGC, CAA, TAA and TAC haplotypes to endometriosis in North Chinese females (50,51).…”

Section: Discussionmentioning

confidence: 66%

Involvement of vascular endothelial growth factor −460 C/T, +405 G/C and +936 C/T polymorphisms in the development of endometriosis

et al. 2014

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Abstract. There are inconsistent data on the contribution of vascular endothelial growth factor (VEGF) -460 C/T (rs833061), +405 G/C (rs2010963) and +936 C/T (rs3025039) single-nucleotide polymorphisms (SNPs) to endometriosis in different ethnicities. Therefore, using high-resolution melting curve analysis, the present study examined the distribution of these SNPs in females with endometriosis-related infertility and a control group. None of the three VEGF SNPs were associated with endometriosis-related infertility in the dominant and recessive models. The lowest P-values of the trend were observed for the VEGF +936 C/T (rs3025039) SNP in endometriosis-related infertility (P trend =0.149). Similarly, haplotype analyses of VEGF SNPs did not demonstrate any SNP combination as a risk for endometriosis-related infertility, and the lowest overall P-values, P=0.141 and P corr =0.395, were observed for a haplotype (TGT) of the above SNPs. Taken together, these results did not demonstrate the contribution of

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Section: Discussionmentioning

confidence: 66%

Involvement of vascular endothelial growth factor −460 C/T, +405 G/C and +936 C/T polymorphisms in the development of endometriosis

et al. 2014

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“…[3][4][5][6][7][9][10][11][12][13][14][15][16][17][18][19][20] The VEGF genetic polymorphisms have been indicated to play an important effect on the regulation of VEGF gene expression that results in altered levels of VEGF, and may contribute to the pathogenesis of endometriosis. 7,16,29 Several studies have reported on the potential association of VEGF þ405G>C genetic polymorphism with endometriosis risk.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, several published articles indicated that the vascular endothelial growth factor (VEGF) is one of the most important candidate genes for the development of endometriosis, and genetic polymorphisms in VEGF gene might be potentially associated with the risk of endometriosis. [3][4][5][6][7][9][10][11][12][13][14][15][16][17][18][19][20] The þ405G>C genetic polymorphism in 5 0 -untranslated region of VEGF gene (rs2010963), one of the most studied genetic variants resulting from G to C mutations, has been reported to affect on the regulation of VEGF gene expression and contributed to the risk of endometriosis in diverse populations. [3][4][5][6][7][9][10][11][12][13][14][15][16][17] However, findings from these published articles were conflicting but not conclusive.…”

Section: Introductionmentioning

confidence: 99%

The association between vascular endothelial growth factor (VEGF) +405G>C genetic polymorphism and endometriosis

Fang

Gong

Wang

2015

Exp Biol Med (Maywood)

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The vascular endothelial growth factor (VEGF) is one of the most important candidate genes for the development of endometriosis, and VEGF genetic polymorphisms might be potentially associated with endometriosis risk. However, the results still remain controversial. The objective of this study aimed to perform a comprehensive meta-analysis to explore a better understanding of the effects of VEGF þ405G>C genetic polymorphism on the risk of endometriosis. A total of eleven eligible studies were eventually identified in this meta-analysis, including 2829 endometriosis cases and 2947 controls. In the overall analysis, no significant association between the VEGF þ405G>C genetic polymorphism and the risk of endometriosis was detected in all genetic models ( In the subgroup analysis by ethnicities, there was no significant association between VEGF þ405G>C genetic polymorphism and endometriosis risk in Asians and/or Caucasians under all genetic models (all P-values >0.05). No publication bias was observed in this study. This meta-analysis supports that the VEGF þ405G>C genetic polymorphism is not significant associated with the risk of endometriosis.

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“…In this case the T allele was significantly more frequently observed in women with endometriosis compared to the control group [23]. These results were not confirmed by the study performed in Estonia [24]. The study group (n = 150) included women with all four stages of the disease.…”

Section: Discussionmentioning

confidence: 37%

Is M235T polymorphism of the angiotensinogen gene involved in the development of endometriosis?

Kowalczynska¹,

Ferenc²,

Wojciechowski³

et al. 2017

Ginekol Pol

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Objectives: The aim of the study was to analyze the M235T polymorphism of the angiotensinogen (AGT) gene in women with endometriosis and to identify correlations between identified genotypes and the disease progression, its stage and clinical course as well as to evaluate the prognostic value of the investigated polymorphism in patients with endometriosis treated for infertility. Material and methods:The study group consisted of 241 women with minimal to severe stage of endometriosis, the control group (without endometriosis) -127. The molecular analysis was performed by PCR-RFLP technique.Results: The analysis of the frequency of genotypes and alleles of M235T polymorphism showed no significant differences between the study and the control groups and between the severity grades of the disease (p > 0.05). No such differences were reported in the case of different localizations of the disease lesions, either. Evaluation of the correlations related to pain accompanying endometriosis did not demonstrate association with any genotypes of the analyzed AGT gene polymorphism. Comparison of the results obtained in the group in which infertility treatment was successful (n = 54) and in those who failed to conceive (n = 73) did not show the correlation between the investigated polymorphism and the effect of infertility treatment.Conclusions: M235T polymorphism of the AGT gene seems unrelated to the development or the clinical course of endometriosis. No prognostic value has been found of the investigated polymorphism in predicting the effects of infertility treatment in women with endometriosis.

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Genetic variations in vascular endothelial growth factor but not in angiotensin I-converting enzyme genes are associated with endometriosis in Estonian women

Cited by 26 publications

References 32 publications

Involvement of vascular endothelial growth factor −460 C/T, +405 G/C and +936 C/T polymorphisms in the development of endometriosis

Involvement of vascular endothelial growth factor −460 C/T, +405 G/C and +936 C/T polymorphisms in the development of endometriosis

The association between vascular endothelial growth factor (VEGF) +405G>C genetic polymorphism and endometriosis

Is M235T polymorphism of the angiotensinogen gene involved in the development of endometriosis?

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