Genetic variations of cholesteryl ester transfer protein and diet interactions in relation to lipid profiles and coronary heart disease: a systematic review

Abstract

Data on diet–genotype interactions in the prevention or treatment of dyslipidemia have increased remarkably. This systematic review aimed to assess nutrigenetic studies regarding the modulating effect of diet on cholesteryl ester transfer protein (CETP) polymorphisms in relation to metabolic traits.Data were collected through studies published between 2000 and SEP. 2016 using five electronic databases. The quality of eligible studies was assessed using a 12-item quality checklist, derived from the STrengthening the REporting of Genetic Association Studies (STREGA) statement. CETP variants that had associations with lipid profiles in previous studies were extracted for drawing of the linkage disequilibrium (LD) plot.Among CETP variants, the rs9989419 best represented this genome wide association signal across all populations, based on LD r2 estimates from 1000 genomes references. In the 23 found eligible studies (clinical trials and observational), the TaqIB and I405V polymorphisms were the two most intensively studied. Two studies reported the effect of interaction between rs3764261 and diet on lipid levels. Regarding the rs708272 (Taq1B), individuals with the B1 risk allele showed better responses to dietary interventions than those with B2B2 genotype, whereas with I405V, inconsistent results have been reported. Modest alcohol consumption was associated with decreased risk of coronary heart disease among B2 carriers of rs708272.It is concluded that variations in the CETP gene may modulate the effects of dietary components on metabolic traits. These results have been controversial, indicating complex polygenic factors in metabolic response to diet and lack of uniformity in the study conditions and designs.Electronic supplementary materialThe online version of this article (10.1186/s12986-017-0231-1) contains supplementary material, which is available to authorized users.

Associations of cholesteryl ester transfer protein (CETP) gene variants with pituitary adenoma

“…Association between CETP and dyslipidemia is known and studied [15][16][20][21][22] . Kuivenhoven et al have proved that CETP rs708272 polymorphism's B1 allele was linked with higher CETP and lower HDL-C levels 16 .…”

“…The cholesteryl ester transfer protein (CETP) gene is located in the q21 region of chromosome 16. The product of this gene is a protein of 476 amino acids, which forms a glycoprotein 15 . CETP mediates the exchange of lipids between lipoproteins.…”

“…CETP is synthesized and secreted in many tissues and organs including the brain 19 . It is known that high plasma concentrations of CETP are associated with an increased risk of cardiovascular diseases [15][16][20][21][22] . CETP could also be associated with many diseases such as neurodegenerative diseases [23][24][25][26][27][28] , dementia [24][25][26]28 and cancer 29 .…”

Lipid metabolism genes and predisposition to ischemic heart disease

“…К настоящему времени идентифицировано множество полиморфных вариантов генов, ассоциированных с риском развития полигенных форм ИБС [11]. Наиболее выраженными эффектами в отношении риска развития болезни обладали такие гены, как PCSK9 [11][12][13][14], LPA [10], NPC1L1 [15], ST3GAL4 [16], генный кластер APOE-C1-C2-C4 [17], COBLL1 [15], LRP4 [10], STARD3 [18], ABCA1 [10,19], SCARB1 [20][21][22], CETP [23,24], PLTP [25,26], LCAT [10]. Продукты экспрессии идентифицированных генов не ограничены влияниями на липидный обмен, а вовлечены в разнообразные молекулярные механизмы развития ИБС.…”

“…Ген CETP расположен на хромосоме 16, q13. Полиморф-ный вариант rs3764261 ассоциирован с ИБС в исследованиях, проводимых для китайской [23] и индийской популяций [24]. Была выявлена связь данного полиморфизма с ИБС в японской популяции [49,50].…”