Genetic Variations of Cytokines and Cytokine Receptors in Psoriasis Patients from China

Abstract

Psoriasis is a chronic inflammatory and hyperproliferative skin disease affected by both genetic and environmental factors. The aim of the present study was to investigate polymorphisms in a candidate gene family of interleukin (IL) in unrelated Chinese patients with psoriasis and control subjects without psoriasis. In this case-control study, 200 unrelated Chinese psoriasis patients and 298 age- and sex-matched control subjects were enrolled. Genomic DNA was prepared from peripheral blood obtained from all psoriasis patients and control subjects. We genotyped seven single-nucleotide polymorphisms (SNPs) in candidate genes of six ILs: IL4, IL10, IL12B, IL13, IL15, and IL23R, which have been shown in the literature to be associated with psoriasis in other ethnic groups. Among the seven SNPs in the six IL genes studied, only the rs3212227 in the IL12B gene was found to be associated with psoriasis at genotypic level in the studied population. The C/C genotype in the IL12B gene is a protective factor of psoriasis (P = 0.0218; OR = 0.51; 95% CI: 0.27–0.96) in Chinese. Furthermore, the studied Chinese population has extremely low minor allele frequency for IL23R. Together, the data reveal unique genetic patterns in Chinese that may be in part responsible for the lower risk for psoriasis in this population.

Analysis of association between cytokine gene polymorphisms and psoriatic disease in Russians of East Siberia

“…For IL4, two study have been published so far to the best of our knowledge: one in a Chinese population (Indhumathi et al, 2017) and one in South Indian Tamils (Li et al, 2014).…”

Investigating the genetic association of HCP5,SPATA2,TNIP1,TNFAIP3 and COG6 with psoriasis in Chinese population

“…With single SNP analysis, no association is found between the psoriasis and the SPATA2 . However, when current data were pooled with the data we published previously (Li et al ., ), the prevalence of the homozygous of major alleles for the three SNPs from SPATA2 (G/G at rs495337), IL13 (C/C at rs1800925) and IL15 gene (A/A at rs56245420) is significantly lower in patients with psoriasis (15 of 201) than the control group (49 of 300, P < 0.001). Thus, the combination of variations from the SPATA2 , IL13 and the IL15 genes showed genetic risk contributions for psoriasis in Chinese.…”

A New Risk Polymorphism rs10403848 of CARD8 Significantly Associated with Psoriasis Vulgaris in Northeastern China

“…Finally, we selected four representative common SNPs, rs2043211, rs2288876, rs3745718, and rs10403848, for which the Minor Allele Frequency (MAF) was greater than 0.05 in the HapMap Chinese Han Beijing population. e selection of the CARD8 polymorphism rs2043211, a missense locus, was based on its previous association with autoinflammatory diseases [13,[15][16][17][18][19][20][21][22]. rs2288876 is a synonymous polymorphism, rs3745718 locates on the 3′-untranslated regions, and rs10403848 locates to an intron region.…”

“…e gene polymorphisms of CARD8 have been associated with several inflammatory and immune diseases, such as rheumatoid arthritis [15,16], Crohn's disease [17], gout [18,19], ankylosing spondylitis [20], and atopic dermatitis [21]. Some authors have proposed that psoriasis is associated with other autoimmune diseases, such as arthritis and Crohn's disease [22]. A polymorphism of CARD8 and rs2043211, is associated with the risk of psoriasis in Swedes [13].…”