Genetically modified mosquito: The Malaysian public engagement experience

Subramaniam, Thenmozhi; Lee, Hanlim; Ahmad, Nazni Wasi; Murad, Shahnaz

doi:10.1002/biot.201200282

Cited by 36 publications

(23 citation statements)

References 6 publications

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“…aegypti in Brazil, Malaysia, Cayman Islands, and the United States, and it could potentially be applicable in the control of Ae. albopictus mosquitoes as well (Harris et al 2012, Subramaniam et al 2012, Carvalho et al 2015, Nimmo and Beech 2015. Release of genetically modified mosquitoes in nature might become feasible in arbovirus-endemic settings, for example, transgenic mosquitoes, to suppress the occurrence of vector-competent mosquitoes and hence reduce transmission.…”

Section: Vector Competencementioning

confidence: 99%

Globe-TrottingAedes aegyptiandAedes albopictus: Risk Factors for Arbovirus Pandemics

Lwande

Obanda

Lindström

et al. 2020

Vector-Borne and Zoonotic Diseases

170

109

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Introduction: Two species of Aedes (Ae.) mosquitoes (Ae. aegypti and Ae. albopictus) are primary vectors for emerging arboviruses that are a significant threat to public health and economic burden worldwide. Distribution of these vectors and the associated arboviruses, such as dengue virus, chikungunya virus, yellow fever virus, and Zika virus, was for a long time restricted by geographical, ecological, and biological factors. Presently, arbovirus emergence and dispersion are more rapid and geographically widespread, largely due to expansion of the range for these two mosquitoes that have exploited the global transportation network, land perturbation, and failure to contain the mosquito population coupled with enhanced vector competence. Ae. aegypti and Ae. albopictus may also sustain transmission between humans without having to depend on their natural reservoir forest cycles due to arthropod adaptation to urbanization. Currently, there is no single strategy that is adequate to control these vectors, especially when managing arbovirus outbreaks. Objective: This review aimed at presenting the characteristics and abilities of Ae. aegypti and Ae. albopictus, which can drive a global public health risk, and suggests strategies for prevention and control. Methods: This review presents the geographic range, reproduction and ecology, vector competence, genetic evolution, and biological and chemical control of these two mosquito species and how they have changed and developed over time combined with factors that may drive pandemics and mitigation measures. Conclusion: We suggest that more efforts should be geared toward the development of a concerted multidisciplinary approach.

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Section: Vector Competencementioning

confidence: 99%

Globe-TrottingAedes aegyptiandAedes albopictus: Risk Factors for Arbovirus Pandemics

Lwande

Obanda

Lindström

et al. 2020

Vector-Borne and Zoonotic Diseases

170

109

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show abstract

“…However, it is clear that here, as for conventional genetic engineering of mosquitoes, the relevant research groups have worked hard to clarify and then to comply with all applicable regulations. 8,57,[108][109][110][111] For any self-sustaining genetic system, key questions relate to the initial ability to spread and confer the desired phenotype, and the possibility that evolutionary responses will compromise this, or have some other undesirable effect. Though in principle the large-scale use of such systems may be reversible by further genetic intervention, restoring the status quo ante is at best uncertain; this irreversibility has been a major discussion point in respect of gene drive systems.…”

Section: Gene Drive Systemsmentioning

confidence: 99%

Genetic control ofAedesmosquitoes

Alphey

McKemey

Nimmo

et al. 2013

Pathogens and Global Health

134

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Aedes mosquitoes include important vector species such as Aedes aegypti, the major vector of dengue. Genetic control methods are being developed for several of these species, stimulated by an urgent need owing to the poor effectiveness of current methods combined with an increase in chemical pesticide resistance. In this review we discuss the various genetic strategies that have been proposed, their present status, and future prospects. We focus particularly on those methods that are already being tested in the field, including RIDL and Wolbachia-based approaches.

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“…It shows that a certain degree of dissatisfaction is inherent in this type of approaches, as pointed out also by Subramaniam and collaborators 14 in reporting that "Our [Their] experience showed that despite executing a well-planned transparent public engagement process that was relevant for a release in an uninhabited site, there was still some dissatisfaction from some community groups. "…”

Section: Transgenic Mosquitoes and Malaria Controlmentioning

confidence: 88%

Engineered mosquitoes to fight mosquito borne diseases: not a merely technical issue

Favia

2015

Bioengineered

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Genetically modified mosquito: The Malaysian public engagement experience

Cited by 36 publications

References 6 publications

Globe-TrottingAedes aegyptiandAedes albopictus: Risk Factors for Arbovirus Pandemics

Globe-TrottingAedes aegyptiandAedes albopictus: Risk Factors for Arbovirus Pandemics

Genetic control ofAedesmosquitoes

Engineered mosquitoes to fight mosquito borne diseases: not a merely technical issue

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