Genetics of malocclusion: A review

Mokhtar, Khairani Idah; Bakar, Noraini Abu; Tahir, Aisyah Hanani Md Ali

doi:10.31436/ijohs.v1i1.2

Cited by 5 publications

(4 citation statements)

References 16 publications

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“…It has been suggested that genetic investigations concerning Class II and I malocclusion are scarce and characterized by small sample sizes, uncertainty regarding the generalizability of findings to populations of diverse ancestries, and narrow trait definitions that overlook the intricate phenotypic spectrum of malocclusion (George et al, 2021). Previous studies have identified several gene candidates as genetic contributors to skeletal malocclusion class II and III (some reviewed in: (Subono et al, 2021, Doraczynska-Kowalik et al, 2017, Mokhtar et al, 2020). Across various ethnicities, studies have suggested that genes correlated with mandibular prognathism are situated in different loci.…”

Section: Discussionmentioning

confidence: 99%

MATN1 gene variant (rs1065755) and malocclusion risk: Evidence from Romanian population analysis

Topârcean,

Acatrinei,

Rusu

et al. 2024

Studia Universitatis Babeş-Bolyai Biologia

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Malocclusion, characterized by its diverse phenotypic expression, significantly impacts patients’ quality of life. Over recent years, extensive attention has been directed towards the genetic basis of this condition, particularly focusing on various polymorphisms of the MATN1 gene. Among these, the rs1065755 polymorphism has emerged as particularly relevant, associated with an elevated risk of mandibular prognathism. In this study, employing DNA sequencing, we investigated the extent of association between the rs1065755 SNP and malocclusion risk within the Romanian population. Our approach concentrated on assessing continuous phenotypic variation through four cephalometric measurements, aiming for a comprehensive understanding beyond categorical phenotypes. The findings shed light on the relationship between the MATN1 rs1065755 SNP and the investigated dentofacial disorder, revealing a positive association between TT homozygous individuals and Class II skeletal malocclusion. However, further investigations employing larger sample sizes are necessary to validate these findings conclusively. Keywords: malocclusion, MATN1, rs1065755, cephalometric measurements.

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Section: Discussionmentioning

confidence: 99%

MATN1 gene variant (rs1065755) and malocclusion risk: Evidence from Romanian population analysis

Topârcean,

Acatrinei,

Rusu

et al. 2024

Studia Universitatis Babeş-Bolyai Biologia

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“…Evidence has shown that genetic factors contributed to the susceptibility to malocclusion. 8 However, both patients were still in their growth period, so it was still possible to perform treatment without invasive procedures, such as extraction or surgery. If treatment were not immediately carried out, it would result in more severe skeletal abnormalities, and if it passed the growth stage, correction of the anterior crossbite would be more difficult and might even require combined orthodontic treatment and orthognathic surgery.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Anterior Crossbite with Skeletal Class III Malocclusion during the Growth Period

Utari

2022

IDJ

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Anterior crossbite is the most common problem in Angle class III malocclusion and is aesthetically disturbing. As individuals get older, an anterior crossbite can worsen, impacting the esthetics of the face and the stomatognathic system’s function significantly and requiring immediate treatment. Due to genetics, habitual postures, ethnicity, and environmental variables, the class III malocclusion’s etiology is multifaceted. In terms of treatment, there are three options: growth modification, camouflage, and orthognathic surgical treatment. This case report aims to describe a non-surgical treatment with simple treatment mechanics in two patients who were still in their growth period. Two patients, a sibling aged 14 and 13 years, experienced an anterior crossbite with a deep overbite, diagnosed with Angle class III with skeletal class III relationships. Besides, the profile revealed a concave, with an overjet of -2mm and an overbite of 4mm. The treatments were then performed employing fixed orthodontic appliances with vertical U-loops for protraction of upper anterior teeth and class III intermaxillary elastics to correct molar relationships. The treatment was completed in two years, in which the anterior crossbite was corrected. The molar and canine relationships, which were originally class III, became class I. Loss of tooth 36 was closed, and tooth 38 has fully erupted. Treatment of anterior crossbite needed to be done as soon as possible to prevent more severe abnormalities. In conclusion, a treatment in the growth period with simple techniques resulted in significant improvements in function and aesthetics.

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“…Both for Class II and Class III malocclusions, recent studies assessed correlations between phenotypes and the increasing number of polymorphic loci in candidate genes involved in the growth and development of the structures of the craniofacial complex (EPB41, SSX21P, PLXNA, COL2A1, TGFB3, and LTBP2, to name only few, for Class III [20], and FGFR2, MSX1, MATN1, MYOH1, ACTN3, GHR, KAT6B, HDAC4, and AJUBA for Class II [21]). Molecular pathways implicated in the development of bone (TGFB3, LTBP, KAT6B) and cartilage (GHR, Matrilin-1) have been identified as contributing factors to mandibular size discrepancies and Class III malocclusions characterized by variations in mandibular height and prognathism [5].…”

Section: Introductionmentioning

confidence: 99%

Genetic Insights into Skeletal Malocclusion: The Role of the FBN3 rs7351083 SNP in the Romanian Population

Topârcean,

Acatrinei,

Rusu

et al. 2024

Medicina

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Background and Objectives: irregularities in the growth and development of the jawbones can lead to misalignments of maxillary and mandibular structures, a complex condition known as skeletal malocclusion, one of the most common oral health problems. Skeletal malocclusions, particularly Class II and Class III, can significantly affect facial appearance, chewing efficiency, speech, and overall oral health, often requiring orthodontic treatment or surgery to correct. These dentofacial anomalies are influenced by genetic and environmental factors and exhibit diverse phenotypic expressions. Materials and Methods: in this study, we investigated the correlation between the rs7351083 SNP of the FBN3 gene that encodes a member of the fibrillin protein family and malocclusion risk in a group of 57 patients from Romania. Results: the results shed light on the relationship between the selected genetic marker and the investigated dentofacial disorder, revealing a positive association between the reference allele (A) and Class II and that the alternate allele (G) is associated with Class III. Conclusions: cephalometric analysis revealed no significant differences among genotypes, suggesting that while genetic factors are implicated in malocclusion, they may not directly affect cephalometric parameters or that the sample size was too small to detect these differences. The discovery of an A > T transversion in one individual with a Class II deformity underscores the genetic diversity within the population and the necessity of comprehensive genotyping to uncover rare genetic variants that might influence craniofacial development and the risk of malocclusion. This study highlights the need for larger studies to confirm these preliminary associations.

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Genetics of malocclusion: A review

Cited by 5 publications

References 16 publications

MATN1 gene variant (rs1065755) and malocclusion risk: Evidence from Romanian population analysis

MATN1 gene variant (rs1065755) and malocclusion risk: Evidence from Romanian population analysis

Treatment of Anterior Crossbite with Skeletal Class III Malocclusion during the Growth Period

Genetic Insights into Skeletal Malocclusion: The Role of the FBN3 rs7351083 SNP in the Romanian Population

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