Genetics of Psoriasis and Psoriatic Arthritis

Mathieu, Alessandro; Cauli, Alberto; Vacca, Alessandra; Mameli, Antonella; Passiu, Giuseppe; Porru, Giovanni; Piga, Matteo; Ibba, V.; Mura, Valentina

doi:10.4081/reumatismo.2007.1s.25

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…We found no allelic associations that met region-wide significance criteria (α* = 8.3×10 −5 , adjusting for 601 SNPs evaluated) in the GALA II study. However, the most significant allelic association within the region in GALA II, (rs114235219, KG_ 6_31200283, p = 0.002), and the most significant SNP in the EVE asthma consortium study (rs3132550, p = 3 × 10 −4 ) were both located on PSORS1C1 , a psoriasis susceptibility candidate,(55) as were the two SNPs that achieved nominal significance in both studies (rs3094663 and rs3130564). PSORS1C1 was identified as a risk locus for systemic sclerosis,(56) Stevens-Johnson Syndrome,(57, 58), Crohn's disease,(50) COPD biomarkers,(59) and Behçet's disease(60) in GWAS.…”

Section: Discussionmentioning

confidence: 99%

Genome-wide association study and admixture mapping identify different asthma-associated loci in Latinos: The Genes-environments & Admixture in Latino Americans study

Galanter

Gignoux

Torgerson

et al. 2014

Journal of Allergy and Clinical Immunology

112

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Background Asthma is a complex disease with both genetic and environmental causes. Genome-wide association studies of asthma have mostly involved European populations and replication of positive associations has been inconsistent. Objective To identify asthma-associated genes in a large Latino population with genome-wide association analysis and admixture mapping. Methods Latino children with asthma (n = 1,893) and healthy controls (n = 1,881) were recruited from five sites in the United States: Puerto Rico, New York, Chicago, Houston, and the San Francisco Bay Area. Subjects were genotyped on an Affymetrix World Array IV chip. We performed genome-wide association and admixture mapping to identify asthma-associated loci. Results We identified a significant association between ancestry and asthma at 6p21 (lowest p-value: rs2523924, p < 5 × 10−6). This association replicates in a meta-analysis of the EVE Asthma Consortium (p = 0.01). Fine mapping of the region in this study and the EVE Asthma Consortium suggests an association between PSORS1C1 and asthma. We confirmed the strong allelic association between the 17q21 asthma in Latinos (IKZF3, lowest p-value: rs90792, OR: 0.67, 95% CI 0.61 – 0.75, p = 6 × 10−13) and replicated associations in several genes that had previously been associated with asthma in genome-wide association studies. Conclusions Admixture mapping and genome-wide association are complementary techniques that provide evidence for multiple asthma-associated loci in Latinos. Admixture mapping identifies a novel locus on 6p21 that replicates in a meta-analysis of several Latino populations, while genome-wide association confirms the previously identified locus on 17q21.

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Section: Discussionmentioning

confidence: 99%

Genome-wide association study and admixture mapping identify different asthma-associated loci in Latinos: The Genes-environments & Admixture in Latino Americans study

Galanter

Gignoux

Torgerson

et al. 2014

Journal of Allergy and Clinical Immunology

112

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“…Both conditions may have genetic factors, pathophysiologic overlaps, and risk factors in common. Gene polymorphisms for IL-1, IL-6, and tumor necrosis factor-a are mentioned as risk factors for both psoriasis and periodontitis (Białecka et al, 2015;Ding et al, 2014;Hébert et al, 2014;Mathieu et al 2007;McDevitt et al, 2000;Puri et al, 2015;Reich et al, 2002;Shao et al, 2009). Pathophysiologic similarity between psoriasis and periodontitis includes an activated innate immune cell compartment with neutrophil dominance and a cytokine milieu with the presence of IL-17/tumor necrosis factor-a (Boehncke, 2015;Girolomoni et al, 2012;Hajishengallis, 2014Hajishengallis, , 2015Schö n et al, 2017;Zenobia and Hajishengallis, 2015).…”

Section: Discussionmentioning

confidence: 99%

Oral Health in Patients with Psoriasis—A Prospective Study

Woeste

Graetz

Gerdes

et al. 2019

Journal of Investigative Dermatology

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Psoriasis is associated with periodontitis, a chronic inflammation of the gingival tissue. However, data about periodontal and dental status of psoriasis patients are sparse. Therefore, we conducted a prospective study comparing psoriasis patients with control individuals. 100 psoriasis patients presenting at the outpatient service of a specialized psoriasis center and 101 nonpsoriatic control individuals were included in the study. Oral health was assessed with standardized measures including Bleeding on Probing, Community Periodontal Index, and dental parameters according to the DMFT index (a cumulative index in which teeth [T] are registered as decayed [D], missing [M], and filled [F]). For analysis, a postmatching strategy was applied with 53 pairs of psoriasis patients and nonpsoriatic individuals in which relevant factors with possible impact on oral health status were considered. Logistic regression analyses were executed on the entire psoriasis and control population. According to the results, the matched psoriasis group had significantly higher values on Bleeding on Probing and the Community Periodontal Index compared with matched control individuals. Logistic regression analyses identified significant correlations of the psoriasis group with high Bleeding on Probing and Community Periodontal Index values but not, however, with missing teeth. Psoriasis patients had significantly higher values for parameters addressing periodontal inflammation. Psoriasis management should, therefore, include regular dental checks on periodontal status and respective treatment where required.

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“…Similar to the condition in the majority of rheumatologic diseases, the etiology of PsA is not known exactly; nevertheless, genetic, immunologic, and environmental factors are all presumed to play roles [10]. It was demonstrated that proinflammatory cytokines, like tumor necrosis factor alpha (TNF-α) and interleukin-1 (IL-1), were increased on the skin and synovial membrane in psoriasis and PsA patients [11].…”

Section: Introductionmentioning

confidence: 99%

Clinical features and types of articular involvement in patients with psoriatic arthritis

et al. 2014

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Psoriatic arthritis (PsA) is a psoriasis-associated inflammatory arthritis which causes joint destruction. There are some epidemiologic data about PsA; however, there are no sufficient data from Turkey. Herein, we evaluated the frequency of PsA in the Thrace region of Turkey according to hospital-based data. In addition, we evaluated clinical features and types of joint involvement in PsA patients. We included 172 PsA patients fulfilling CASPAR criteria admitted to the Division of Rheumatology, Trakya University Medical Faculty, between 2003 and 2012. Data from Turkish Statistical Institution was used to calculate the incidence and prevalence of PsA. Patients' demographic features, durations of psoriasis and PsA, number of tender and swollen joints, treatment modalities, laboratory data, and X-ray film findings were recorded from hospital files. The annual incidence of PsA was 2.8/100,000. The mean annual incidence was 3.47/100,000 in females and 2.15/100,000 in males. The overall prevalence of PsA in our region was 27.9/100,000 (95 % confidence interval (CI) 23.7-32.1) in individuals >16 years. The prevalence of PsA was higher in females than in males (34.7/100,000 vs. 21.5/100,000). Polyarthritis was present in 67 (38.9 %), oligoarthritis in 47 (27.3 %), spondyloarthritis in 39 (22.6 %), and distal interphalangeal (DIP) arthritis in 19 (11.0 %) patients. The duration of psoriasis was significantly longer in polyarticular PsA patients than in DIP and oligoarticular groups (p values = 0.016 and 0.018, respectively). The number of swollen joints correlated with age (r = 0.21, p = 0.006), duration of psoriasis (r = 0.20, p = 0.01), number of tender joints (r = 0.92, p ≤ 0.001), ESR (r = 0.24, p = 0.001), and CRP (r = 0.17, p = 0.026). The frequency of PsA in Thrace region is similar to that in low-frequency regions. The most frequent type of involvement was polyarticular, and it correlated with the duration of psoriasis and erosive disease.

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Genetics of Psoriasis and Psoriatic Arthritis

Cited by 4 publications

References 24 publications

Genome-wide association study and admixture mapping identify different asthma-associated loci in Latinos: The Genes-environments & Admixture in Latino Americans study

Genome-wide association study and admixture mapping identify different asthma-associated loci in Latinos: The Genes-environments & Admixture in Latino Americans study

Oral Health in Patients with Psoriasis—A Prospective Study

Clinical features and types of articular involvement in patients with psoriatic arthritis

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