Genetics of suicide: a systematic review of twin studies

Abstract

The totality of evidence from twin studies of suicide strongly suggests genetic contributions to liability for suicidal behavior. To further research progress in this area, an extensive discussion of design limitations, shortcomings of the literature and further points is provided, including sources of bias, gaps in the literature, errors in previous reviews, age and sex effects and twin-singleton differences in suicide risk, and notes from a history-of-science view.

Association between Polymorphisms of the DRD2 and ANKK1 Genes and Suicide Attempt: A Preliminary Case-Control Study in a Mexican Population

“…Over time, diverse risk factors such as epigenetic and genetic factors have been studied [2]. The genetic studies in particular have been based on families, adopted individuals, and twins [3, 4]. …”

Suicide, mental disorder and responsibility

“…For completeness, it is important to note that suicide is influenced by societal factors (Durkheim, 1951), education level, socioeconomic status, gender, age and level of intoxication, and that genetics accounts for 30À55% of suicide risk (Voracek & Loibl, 2007).…”

Analysis of sociodemographic data of the patients presented to a state hospital because of suicide attempt

“…Çalışmada hastaların %64.18'inin kadın, %35.82'sinin erkek olduğu saptandı. Dünyanın birçok yerinde intihar girişimi kadınlarda özellikle genç yaşlarda daha sıktır (13). Erkeklerde intihar girişimi insidansının kadınlara kıyasla daha düşük olması, erkeklerin hayatlarını kontrol etmelerinin gereğine olan inançlarından kaynaklanmaktadır (14).…”