GeneXpert MTB/RIF Sputum MTB Detection and Human Immunodeficiency Virus Seroprevalence among Patients with Presumptive Pulmonary Tuberculosis at a New Teaching Hospital in North-Central Nigeria

Mbaave, PT; Igbudu, Terhemen Joseph; Egwuda, Livinus; Audu, Onyemocho; Jombo, Gta

doi:10.20546/ijcmas.2016.508.062

Cited by 3 publications

(2 citation statements)

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“…The sero-prevalence of HIV infection among the patients is 22.58%. This is slightly higher than that reported Yusuf et al of 18.8% in Kano, 17 North-Western, Nigeria, but lower than that reported by Ige et al in Ibadan, South-western, Nigeria of 28.12%, 18 Mbaave et al of 48% 19 in North-Central, Nigeria and by Corbett et al of 38% in sub-Saharan Africa. 4 This variation in the prevalence could be due to difference in location of the study as the prevalence of HIV infection has been reported to have geographical variation in several other African studies.…”

Section: Discussioncontrasting

confidence: 53%

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Sero-prevalence of human immunodeficiency virus infection among patients with newly diagnosed pulmonary tuberculosis in a teaching hospital in Bauchi, North-Eastern Nigeria

et al. 2018

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About a third of the human immunodeficiency virus (HIV) positive population worldwide is co-infected with Mycobacterium tuberculosis. However, data are lacking about the prevalence of HIV among patients with pulmonary tuberculosis (PTB) in a teaching hospital in Bauchi, northeast Nigeria. The aim of this study is to determine the sero-prevalence of HIV among patients with sputum smear positive PTB at Abubakar Tafawa Balewa University Teaching Hospital (ATBUTH), Bauchi, Bauchi State, Nigeria. This is a retrospective study review of patients’ medical records diagnosed with sputum smear positive PTB that attended and received treatment at directly observed treatment short course (DOTS) clinic of Abubakar Tafawa Balewa University Teaching Hospital (ATBUTH), Bauchi, Bauchi State, North-Eastern Nigeria from January, 2015- December, 2017. All the patients were newly diagnosed with sputum smear positive PTB using ZN stain testing of their sputum and screened for HIV antibodies. There were 155 patients studied comprising of 95 (61.29%) males and 60 (38.71%) females. One hundred and twenty (77.42%) patients were seronegative and 35 (22.58%) sero-positive for HIV. Most of the patients were within the ages of 15-54 years with mean age of 34.63±15.55. The sero-prevalence of HIV infection among the patients is 22.58%. Sero-prevalence of HIV is observed to be high among young and married patients with secondary level of education. The sero-prevalence of HIV infection among the patients is relatively lower than those reported in most parts of Nigeria and the sub-Saharan Africa, hence there is still need for continued screening of HIV antibodies among patients with PTB so as to reduce the morbidity and mortality that may result from the coinfection.

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Section: Discussioncontrasting

confidence: 53%

“…16 Many studies have been done in parts of Nigeria on prevalence of HIV among TB patients with prevalence of 18.8% in Kano, 17 28.12% in Ibadan 18 and 48% in North-Central, Nigeria. 19…”

Section: Introductionmentioning

confidence: 99%

Sero-prevalence of human immunodeficiency virus infection among patients with newly diagnosed pulmonary tuberculosis in a teaching hospital in Bauchi, North-Eastern Nigeria

et al. 2018

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A systemic review on tuberculosis

Natarajan

Beena

Devnikar

et al. 2020

Indian Journal of Tuberculosis

207

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Extra-Pulmonary Mycobacterium tuberculosis

Shi,

Li,

Xing

2024

Infectious Diseases

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Extra-pulmonary Mycobacterium tuberculosis (EPTB) is a threat and challenge to human health that affects bone, urinary, skin, soft tissues, and lymph nodes. EPTB always comes from pulmonary tuberculosis (PTB), while there are some patients who have never had any PTB symptoms or (and) evidence of PTB infection. There are a few patients who have EPTB infection from the onset. Additionally, drug-resistant Mycobacterium tuberculosis (DR-MTB) is a bigger threat to human health. Drug-resistant extra-pulmonary Mycobacterium tuberculosis (DR-EPTB) also affects some patients who have never been diagnosed with PTB and have no symptoms of PTB, although these patients are rarely detected due to deficiencies in the methods of detection. MTB is always transmitted through the air, while EPTB is transmitted through some special approaches. There are different detection methods that have their respective advantages and disadvantages. MTB evolves to DR-MTB due to the gene mutations that are mainly caused by the endogenous and exogenous reasons, which are also suitable for EPTB. An in-depth study of the genome of MTB will contribute to advances in diagnosis, treatment, and prevention.

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GeneXpert MTB/RIF Sputum MTB Detection and Human Immunodeficiency Virus Seroprevalence among Patients with Presumptive Pulmonary Tuberculosis at a New Teaching Hospital in North-Central Nigeria

Cited by 3 publications

References 8 publications

Sero-prevalence of human immunodeficiency virus infection among patients with newly diagnosed pulmonary tuberculosis in a teaching hospital in Bauchi, North-Eastern Nigeria

Sero-prevalence of human immunodeficiency virus infection among patients with newly diagnosed pulmonary tuberculosis in a teaching hospital in Bauchi, North-Eastern Nigeria

A systemic review on tuberculosis

Extra-Pulmonary Mycobacterium tuberculosis

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