Geniposide alleviated bile acid-associated NLRP3 inflammasome activation by regulating SIRT1/FXR signaling in bile duct ligation-induced liver fibrosis

Qin, Tingting; Hasnat, Muhammad; Wang, Ziwei; Hassan, Hozeifa Mohamed; Zhang, Yang; Yuan, Ziqiao; Zhang, Wenzhou

doi:10.1016/j.phymed.2023.154971

Cited by 6 publications

(2 citation statements)

References 46 publications

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“…Although the above-mentioned study reveals geniposide’s inhibitory effect on hepatic FXR in mice fed a high-fat diet, its promoting effect on FXR has been observed in bile duct ligation-induced cholestasis in mice models. Research has shown that the binding of geniposide to sirtuin 1 (SIRT1) increases the deacetylation of hepatic FXR and restores bile acid profiles/contents, especially those of chenodeoxycholic acid (CDCA), tauroursodeoxycholic acid (TUDCA), and taurochenodeoxycholic acid (TCDCA), ultimately ameliorating liver fibrosis . Therefore, phytochemicals might exhibit distinct effects under different disease conditions, and their benefits should be further clarified.…”

Section: Association Of Bile Acids With Cholesterol Homeostasismentioning

confidence: 99%

“…Research has shown that the binding of geniposide to sirtuin 1 (SIRT1) increases the deacetylation of hepatic FXR and restores bile acid profiles/contents, especially those of chenodeoxycholic acid (CDCA), tauroursodeoxycholic acid (TUDCA), and taurochenodeoxycholic acid (TCDCA), ultimately ameliorating liver fibrosis. 50 Therefore, phytochemicals might exhibit distinct effects under different disease conditions, and their benefits should be further clarified. Li et al (2023) have reported similar results, demonstrating that vine tea extract restores hepatic and ileum FXR and ASBT—inhibiting bile acid synthesis and promoting its transport and reabsorption—and can serve as a means to improve hepatic injury.…”

Section: Association Of Bile Acids With Cholesterol Homeostasismentioning

confidence: 99%

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Exploring Phytochemical Mechanisms in the Prevention of Cholesterol Dysregulation: A Review

Weerawatanakorn,

Kamchonemenukool,

Koh

et al. 2024

J. Agric. Food Chem.

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Although cholesterol plays a key role in many physiological processes, its dysregulation can lead to several metabolic diseases. Statins are a group of drugs widely used to lower cholesterol levels and cardiovascular risk but may lead to several side effects in some patients. Therefore, the development of a plant-based therapeutic adjuvant with cholesterol-lowering activity is desirable. The maintenance of cholesterol homeostasis encompasses multiple steps, including biosynthesis and metabolism, uptake and transport, and bile acid metabolism; issues arising in any of these processes could contribute to the etiology of cholesterolrelated diseases. An increasing body of evidence strongly indicates the benefits of phytochemicals for cholesterol regulation; traditional Chinese medicines prove beneficial in some disease models, although more scientific investigations are needed to confirm their effectiveness. One of the main functions of cholesterol is bile acid biosynthesis, where most bile acids are recycled back to the liver. The composition of bile acid is partly modulated by gut microbes and could be harmful to the liver. In this regard, the reshaping effect of phytochemicals on gut microbiota has been widely reported in the literature for its significance. Therefore, we reviewed studies conducted over the past 5 years elucidating the regulatory effects of phytochemicals or herbal medicines on cholesterol metabolism. In addition, their effects on the recomposition of gut microbiota and bile acid metabolism due to modulation are discussed. This review aims to provide novel insights into the treatment of cholesterol dysregulation and the anticipated development of natural-based compounds in the near and far future.

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Section: Association Of Bile Acids With Cholesterol Homeostasismentioning

confidence: 99%

Section: Association Of Bile Acids With Cholesterol Homeostasismentioning

confidence: 99%

Exploring Phytochemical Mechanisms in the Prevention of Cholesterol Dysregulation: A Review

Weerawatanakorn,

Kamchonemenukool,

Koh

et al. 2024

J. Agric. Food Chem.

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A metabolomics study on the mechanisms of Gardeniae fructus against α‐naphthylisothiocyanate‐induced cholestatic liver injury

Cao,

Li,

Zhang

et al. 2024

Biomedical Chromatography

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Gardeniae fructus (GF) is known for its various beneficial effects on cholestatic liver injury (CLI). However, the biological mechanisms through which GF regulates CLI have not been fully elucidated. This study aimed to explore the potential mechanisms of GF against α‐naphthylisothiocyanate (ANIT)‐induced CLI. First, HPLC technology was used to analyze the chemical profile of the GF extract. Second, the effects of GF on serum biochemical indicators and liver histopathology were examined. Lastly, metabolomics was utilized to study the changes in liver metabolites and clarify the associated metabolic pathways. In chemical analysis, 10 components were identified in the GF extract. GF treatment regulated serum biochemical indicators in ANIT‐induced CLI model rats and alleviated liver histological damage. Metabolomics identified 26 endogenous metabolites as biomarkers of ANIT‐induced CLI, with 23 biomarkers returning to normal levels, particularly involving primary bile acid biosynthesis, glycerophospholipid metabolism, tryptophan metabolism, and arachidonic acid metabolism. GF shows promise in alleviating ANIT‐induced CLI by modulating multiple pathways.

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Angong Niuhuang Pill pretreatment alleviates cerebral ischemia-reperfusion injury by inhibiting excessive autophagy through the SIRT1-H4K16ac axis

Wang,

Hou,

et al. 2025

Journal of Ethnopharmacology

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Geniposide alleviated bile acid-associated NLRP3 inflammasome activation by regulating SIRT1/FXR signaling in bile duct ligation-induced liver fibrosis

Cited by 6 publications

References 46 publications

Exploring Phytochemical Mechanisms in the Prevention of Cholesterol Dysregulation: A Review

Exploring Phytochemical Mechanisms in the Prevention of Cholesterol Dysregulation: A Review

A metabolomics study on the mechanisms of Gardeniae fructus against α‐naphthylisothiocyanate‐induced cholestatic liver injury

Angong Niuhuang Pill pretreatment alleviates cerebral ischemia-reperfusion injury by inhibiting excessive autophagy through the SIRT1-H4K16ac axis

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