2014
DOI: 10.1155/2014/619617
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Genistein Induces Deleterious Effects during Its Acute Exposure in Swiss Mice

Abstract: Genistein is a soy derived isoflavone. It has wide variety of therapeutic effects against certain diseases including cancer. Although toxic effects of genistein have been studied, its effect on the gene expression and the reason behind toxicity have not been identified yet. In the present study, genistein was administered to age and body weight matched Swiss mice at the doses of 125, 250, 500 and 1000 mg/kg. The biomarkers of hepatotoxicity in serum, liver histology, oxidative stress parameters in tissue homog… Show more

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Cited by 28 publications
(21 citation statements)
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“…These data, in combination with other potential adverse effects reported in previous studies (Kim et al 2013;Singh et al 2014), support a cautious approach to the introduction of high doses of genistein in patients with various MPSs and underscores the need for well-designed and controlled clinical trials allowing the collection of all potential adverse effects over longer periods of time.…”
Section: Discussionsupporting
confidence: 72%
See 1 more Smart Citation
“…These data, in combination with other potential adverse effects reported in previous studies (Kim et al 2013;Singh et al 2014), support a cautious approach to the introduction of high doses of genistein in patients with various MPSs and underscores the need for well-designed and controlled clinical trials allowing the collection of all potential adverse effects over longer periods of time.…”
Section: Discussionsupporting
confidence: 72%
“…An in vivo study with a high dose of genistein in MPS IIIB mice showed reduced GAG levels in brain and impressive amelioration of neurological symptoms (Malinowska et al 2010). Although genistein appears to be well tolerated in high doses, adverse effects, which are associated with its potential antiproliferative and estrogenic actions, have been reported and may include hepatotoxicity and hormonal disbalance (Kim et al 2013;Singh et al 2014). The only study on the effects of genistein on MPSrelated bone disease showed increased range of joint motion in genistein-treated MPS II patients, suggesting that genistein at least reaches the surrounding connective and muscle tissue of the joints (Marucha et al 2011).…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, both quercetin (oral administration) and genistein (intraperitoneal administration) upregulate Nrf2 nuclear translocation in broiler chickens (LPS-induced intestinal oxidative stress) and male Sprague-Dawley rats (cerebral ischemia-induced oxidative stress) [ 111 , 138 ]. Further, the tested concentrations of genistein on Sprague-Dawley rats were much lower than concentrations that show toxic effects in mice [ 139 ].…”
Section: Role Of the Nrf2/are Pathway In Cancer Chemopreventionmentioning
confidence: 99%
“…Furthermore, the oral administration of baicalin and hesperidin upregulated HO-1 at both the protein and mRNA levels against Mycoplasma gallisepticum infection-induced oxidative stress in chicken and MTX-induced hepatotoxicity in male Sprague-Dawley rats, respectively [ 104 , 116 ]. More importantly, the above upregulations of either or both antioxidant and phase 2 detoxifying enzymes by luteolin (ICR mice and Sprague-Dawley rats), baicalein (T2DM Kunming mice), baicalin (Sprague-Dawley rats), hesperidin (Sprague-Dawley rats) and genistein (Sprague-Dawley rats) were observed in concentrations lower than toxic or lethal in in vivo studies [ 99 , 114 , 133 , 134 , 136 , 139 ]. Based on the reported literature, further investigations should be carried out so as to better understand the molecular mechanisms of the effects of flavonoids in facilitating the activation, stabilization and nuclear translocation of Nrf2, and ARE-driven gene expression.…”
Section: Role Of the Nrf2/are Pathway In Cancer Chemopreventionmentioning
confidence: 99%
“…Particularly, levels of following enzymes were elevated: alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase. Moreover, degeneration of liver was noted, and oxidative stress parameters were increased (Singh et al 2014 ). However, no such effects were observed at lower doses (160 mg/kg/day or less) in wild-type and MPS IIIB mice (Malinowska et al 2009 , 2010 ).…”
Section: Clinical Trialsmentioning
confidence: 99%