“…Compared to HSV-2, infection with HSV-1 has a milder course and fewer recurrences. HSV-1 (which was previously thought to cause only oral lesions) actually causes up to 50% of genital herpes infections [32,77,78], although it is often neglected in prevalence estimates [1]. HSV-1 may be spread to the genitals through oral sex, and both serotypes may be present in anogenital lesions.…”