Genital tuberculosis in women

Falk, Viking; Ludviksson, Konrad; Ågren, Göran I.

doi:10.1016/0002-9378(80)91090-x

Cited by 41 publications

(6 citation statements)

References 5 publications

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“…7,8 The frequency of genital tuberculosis was 0.002% of all patients admitted for gynaecologic diseases. 9 In postmenopausal women genital tuberculosis is rare and seen in 1% of patients with postmenopausal bleeding. 10 The exact cause of low incidence of the disease in this age group is not known.…”

Section: Discussionmentioning

confidence: 99%

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A Ten year Clinicopathological Study of Female Genital Tuberculosis and Impact on Fertility

Mondal

Dutta

2008

J Nepal Med Assoc

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INTRODUCTION:To determine the histological pattern of involvement, clinical presentation, impact on fertility in women with genital tuberculosis.METHODS:A total number of 68 cases of gynaecological tuberculosis affecting different parts of female genital tract from 56 patients were selected. The age range of the patients was 17-36 years with mean age of 25.6 years. The diagnostic procedures used included endometrial curettage and biopsy, histopathological examination, culture and Mycobacterium Tuberculosis Polymerase Chain Reaction (MTB PCR), laparoscopy, Hysterosalpingography (HSG) and Ultrasonography (USG). Most of the specimens received were biopsies of endometrial curettage for evaluation of infertility. In 7 cases, specimens of total hysterectomy with bilateral salpingo-oophorectomy were submitted with lesions involving multiple sites.RESULTS:Patients presented with infertility (65-70%), pelvic/abdominal pain (50-55%), and menstrual disturbances (20-25%). Tuberculosis involved the endometrium in 55.88%, tubes in 23.53%, ovaries in 14.71% and cervix in 5.88% of the 68 cases. The endometrium(38 cases)was in the proliferative phase in 31 cases (81.57%), secretory phase in 4 cases (10.52%) and it was atrophic in 3 cases (7.89%).Caseation was present in 9 out of 68 cases and Ziehl-Neelsen (ZN) stain revealed Acid Fast Bacilli (AFB) in tissue sections in only 4 cases . After therapy, 9 patients conceived of which 8 suffered spontaneous abortions. Only one patient had a successful pregnancy and the baby was born through caesarean section.CONCLUSIONS:Genital tuberculosis is an important cause of female infertility in developing countries like India, Nepal, Bangladesh and Pakistan. Successful uterine pregnancy is rare after treatment and chances of ectopic pregnancy are high.Keywords: Key Words:female infertility, genital tuberculosis, histology

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Section: Discussionmentioning

confidence: 99%

“…Since 1950, however, the peak incidence has shifted to the perimenopause as infertility has been superseded by abnormal uterine bleeding and pelvic pain as dominant complaint in the developed countries. 9,11 Genital tuberculosis is usually an indolent infection and takes years to manifest clinically after initial seeding.…”

Section: Discussionmentioning

confidence: 99%

A Ten year Clinicopathological Study of Female Genital Tuberculosis and Impact on Fertility

Mondal

Dutta

2008

J Nepal Med Assoc

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“…Its occurrence in the postmenopausal woman was an uncommon condition in the earlier surveys (15,16). Recent studies, however, have observed a change in the age distribution and the proportion of patients over 40 years of age is much higher than in the past (17, 18,19). Clinicians must be aware of such a possibility in any patient with postmenopausal vaginal bleeding or discharge who does not have cervical or endornetrial carcinoma.…”

Section: Discussionmentioning

confidence: 92%

Postmenopausal Tuberculous Cervicitis

Tang

1986

Acta Obstet Gynecol Scand

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“…In endometrial tuberculosis, infertility is due to functionally altered endometrium or associated tuberculous salpingitis [19]. Tubercular infection greatly suppresses the sensitivity of the endometrium to ovarian hormones leading to deficient secretory phase and defective secretion of glycogen [20].…”

Section: Discussionmentioning

confidence: 99%

Hysteroscopy findings and its correlation with latent endometrial tuberculosis in infertility

Mohakul¹,

Beela²,

Tiru³

2014

Gynecol Surg

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In India, 5 to 18 % of females attending infertility clinics are diagnosed to be suffering from genital tuberculosis. The present study was conducted to find out the prevalence of endometrial tuberculosis in infertility and its correlation with hysteroscopic changes. Patients attending infertility clinic with history of more than 2 years of unexplained infertility, failure to conceive in spite of successful ovulation induction in anovulatory infertility, and secondary infertility with a history of unexplained abortion or ectopic pregnancy were included in the study. In all the 105 cases, hysteroscopy was done, and the endometrium was subjected to DNA-PCR (polymerase chain reaction) testing for detection of Mycobacterium tuberculosis infection. Hysteroscopy features were compared in tuberculosis positive (39 %) and negative (61 %) cases for correlation. Tuberculosis was detected in 43.75 % of ostial and periostial fibrosis, 48.48 % of intrauterine fibrosis, and 66.67 % of the irregular cavity surface. A complete 6-month course of antitubercular treatment was given to the tuberculosis positive cases among which 39 % conceived without any additional treatment. The pregnancy rate of 64.7 % in secondary infertility and 20.8 % in primary infertility was very much promising. Tuberculosis is one of the major etiological factors in female infertility in developing countries. Preliminary assessment by hysteroscopy followed by PCR testing for Mycobacterium tuberculosis will detect it early. Subsequent antitubercular treatment may reverse the reproductive capability and prevent permanent damage to the female reproductive organs.

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Genital tuberculosis in women

Cited by 41 publications

References 5 publications

A Ten year Clinicopathological Study of Female Genital Tuberculosis and Impact on Fertility

A Ten year Clinicopathological Study of Female Genital Tuberculosis and Impact on Fertility

Postmenopausal Tuberculous Cervicitis

Hysteroscopy findings and its correlation with latent endometrial tuberculosis in infertility

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