2020
DOI: 10.1111/his.14198
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Genital verruciform xanthoma: lessons from a contemporary multi‐institutional series

Abstract: Aims: Verruciform xanthoma (VX) is an uncommon lesion, seen in the oral mucosa and rarely occurring at cutaneous genital sites. Reports of exceptional VX presentations dominate the literature; herein, we assess the clinical and histological features of a cohort of routine, consecutive cases. Methods and results: Clinicopathological features of genital VXs from four academic centres were reviewed. A cohort of 25 lesions from 24 patients (22 male, two female; median age = 62 years), occurred on the scrotum (84%)… Show more

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Cited by 4 publications
(2 citation statements)
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“…Clinically, VX is presented as Papillary or cauliflower-like growth commonly seen in the oral mucosa and is sometimes pedunculated. Microscopically, the lesion has a hallmark of accumulation of foamy macrophages with lipid-containing vacuoles; however, VX shares hyperkeratosis, parakeratosis, and papillomatosis with VV [31][32][33][34][35][36] . In addition to the differential diagnosis, VV has several variants [Figure 2].…”
Section: Discussionmentioning
confidence: 99%
“…Clinically, VX is presented as Papillary or cauliflower-like growth commonly seen in the oral mucosa and is sometimes pedunculated. Microscopically, the lesion has a hallmark of accumulation of foamy macrophages with lipid-containing vacuoles; however, VX shares hyperkeratosis, parakeratosis, and papillomatosis with VV [31][32][33][34][35][36] . In addition to the differential diagnosis, VV has several variants [Figure 2].…”
Section: Discussionmentioning
confidence: 99%
“… 1 The second main feature is the papillomatous appearance, including plaque-like configurations, more polypoid papular proliferations to lesions, discrete frondular papillae overlying ectatic basal vessels and variable chronic inflammation. 27 …”
Section: Introductionmentioning
confidence: 99%