Genitourinary Tuberculosis After Renal Transplantation—A Report of Three Cases with a Good Clinical Outcome

Nayak, Sunil S; Satish, Renuka

doi:10.1111/j.1600-6143.2007.01853.x

Cited by 12 publications

(9 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A graft nephrectomy was performed; however acid-fast bacilli could not be demonstrated in the background of histiocytic granulomas. A recent report from India has described three patients with posttransplant tuberculosis of urinary tract in whom the diagnosis was confirmed by detection of acid-fast bacilli in urine and all the patients responded favorably to antitubercular treatment [6]. Another report from India has described a patient with posttransplant tuberculosis with a kidney biopsy showing epithelioid cell granulomas and necrosis.…”

Section: Discussionmentioning

confidence: 95%

“…Lungs are the most common site for tuberculosis in posttransplant setting [2,3]. Although tubercular involvement of the graft has been reported to occur in association with disseminated tuberculosis, reports of isolated tuberculosis of the renal allograft are infrequent in the literature [4][5][6][7]. In the majority of such cases the diagnosis has been made after graft nephrectomy [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Renal allograft tuberculosis: report of three cases and review of literature

et al. 2009

View full text Add to dashboard Cite

Renal transplant recipients are prone to a variety of infections due a persistent immunodepleted state. Incidence of tuberculosis in this population is much higher compared with the general population. While pulmonary tuberculosis still remains the commonest form in this population, renal allograft tuberculosis is very rare. We report two cases of isolated allograft tuberculosis and one case of allograft tuberculosis with coexistent pleuro-pulmonary and bone marrow involvement. All three cases had presented with pyrexia of unknown origin, wherein despite extensive investigations the cause was not found. In two cases the diagnosis was confirmed on histology. Two cases responded to non-rifampicin-based modified antitubercular treatment and one to conventional four-drug Rifampicin-based regimen. Graft function improved in two cases while in one case the graft was lost. Tuberculosis involving the renal allograft is a potential cause for graft dysfunction/loss and requires a high index of suspicion for diagnosis. Timely detection and early institution of therapy can help save the renal allograft.

show abstract

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Renal allograft tuberculosis: report of three cases and review of literature

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Predominantly parenchymatous renal involvement was more frequent in immunocompromised patients, who also had lower frequency of stenosis of the collecting system and contracted bladder [31,37].…”

Section: Discussionmentioning

confidence: 99%

Mycobacterium Tuberculosis Infection Following Kidney Transplantation

Boubaker¹,

Abderrahim²,

Abdallah³

et al. 2013

AJIDM

View full text Add to dashboard Cite

Introduction and Aims. Post-transplant tuberculosis (TB) is a problem in successful long-term outcome of renal transplantation recipients. Our objective was to describe the pattern and risk factors of TB infection and the prognosis in our transplant recipients. Patients and Methods. This study was a retrospective review of the records of 491 renal transplant recipients in our hospital during the period from January 1986 to December 2009. The demographic data, transplant characteristics, clinical manifestations, diagnostic criteria, treatment protocol, and long-term outcome of this cohort of patients were analyzed. Results. 16 patients (3,2%) developed post-transplant TB with a mean age of 32,5 ± 12,7 (range: 13-60) years and a mean post-transplant period of 36,6months (range: 12,3 months-15,9 years). The forms of the diseases were pulmonary in 10/16 (62,6%), disseminated in 3/16 (18,7%), and extrapulmonary in 3/16 (18,7%). Graft dysfunction was observed in 7 cases (43,7%) with tissue-proof acute rejection in 3 cases and loss of the graft in 4 cases. Hepatotoxicity developed in 3 patients (18,7%) during treatment. Recurrences were observed in 4 cases after early stop of treatment. Two patients (12.5%) died. Conclusion. Extra pulmonary and disseminated tuberculosis were observed in third of our patients. More than 9months of treatment may be necessary to prevent recurrence.

show abstract

“…[7778] TB occurs in an estimated 0.35-6.5% of organ transplant recipients,[79] significantly increasing their mortality (up to 17.86%). [71] The incidence reported from India is much higher, between 5.7% and 13.5%,[80] which is probably related to the higher incidence of TB.…”

Section: Tb In Transplanted Kidneysmentioning

confidence: 99%

Tuberculosis of the genitourinary system-Urinary tract tuberculosis: Renal tuberculosis-Part II

Merchant

Bharati

Merchant

2013

Indian J Radiol Imaging

View full text Add to dashboard Cite

This article reviews the computed tomography and magnetic resonance imaging (MRI) features of renal tuberculosis (TB), including TB in transplant recipients and immunocompromised patients. Multi detector computed tomography (MDCT) forms the mainstay of cross-sectional imaging in renal TB. It can easily identify calcification, renal scars, mass lesions, and urothelial thickening. The combination of uneven caliectasis, with urothelial thickening and lack of pelvic dilatation, can also be demonstrated on MDCT. MRI is a sensitive modality for demonstration of features of renal TB, including tissue edema, asymmetric perinephric fat stranding, and thickening of Gerota's fascia, all of which may be clues to focal pyelonephritis of tuberculous origin. Diffusion-weighted MR imaging with apparent diffusion coefficient (ADC) values may help in differentiating hydronephrosis from pyonephrosis. ADC values also have the potential to serve as a sensitive non-invasive biomarker of renal fibrosis. Immunocompromised patients are at increased risk of renal TB. In transplant patients, renal TB, including tuberculous interstitial nephritis, is an important cause of graft dysfunction. Renal TB in patients with HIV more often shows greater parenchymal affection, with poorly formed granulomas and relatively less frequent findings of caseation and stenosis. Atypical mycobacterial infections are also more common in immunocompromised patients.

show abstract

Genitourinary Tuberculosis After Renal Transplantation—A Report of Three Cases with a Good Clinical Outcome

Cited by 12 publications

References 17 publications

Renal allograft tuberculosis: report of three cases and review of literature

Renal allograft tuberculosis: report of three cases and review of literature

Mycobacterium Tuberculosis Infection Following Kidney Transplantation

Tuberculosis of the genitourinary system-Urinary tract tuberculosis: Renal tuberculosis-Part II

Contact Info

Product

Resources

About