Genome of Deerpox Virus

Afonso, Claudio L.; Delhon, G.; Tulman, E. R.; Lu, Zhiqiang; Zsak, Aniko; Becerra, Victor M.; Zsák, László; Kutish, G. F.; Rock, Daniel L.

doi:10.1128/jvi.79.2.966-977.2005

Cited by 57 publications

(66 citation statements)

References 68 publications

(68 reference statements)

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“…Genomic analysis indicates that this genus is most similar to the Suipox and Capripox genera (Afonso et al, 2005). Some of the clinicopathologic findings of this study support that conclusion.…”

Section: Discussionsupporting

confidence: 78%

“…The arsenal of DPV genes capable of modifying the host immune and inflammatory responses, cellular growth and signaling pathways, and vasoregulatory mechanisms is impressive (Afonso et al, 2005). Furthermore, Afonso et al (2005) found distinct genetic differences between the two isolates studied, suggesting multiple strains of virus within the species.…”

Section: Discussionmentioning

confidence: 88%

“…Furthermore, Afonso et al (2005) found distinct genetic differences between the two isolates studied, suggesting multiple strains of virus within the species. This has been further supported by partial characterization of three Odocoileus hemionus origin isolates in our laboratory (Moerdyk-Schauwecker et al, 2009).…”

Section: Discussionmentioning

confidence: 96%

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Experimental Deerpox Infection in Black-Tailed Deer (Odocoileus Hemionus Columbianus)

Bildfell

Thompson

Moerdyk-Schauwecker

et al. 2010

Journal of Wildlife Diseases

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ABSTRACT:The pathogenic potential of deerpox virus was investigated via an experimental study utilizing seven black-tailed deer fawns (Odocoileus hemionus) between June and August of 2007. Successful transmission was achieved via intracutaneous and intravenous routes, and by commingling an uninoculated animal with experimentally infected fawns. One fawn became depressed and reluctant to eat but systemic clinical signs in the other fawns were confined to mild transient pyrexia. Typical multifocal poxviral cutaneous lesions of erythema, papules, pustules, ulceration, and crusting were observed. Two locally extensive ulcerative lesions also developed at inoculation sites. Oral lesions were seen in one commingled fawn, with some palatine epithelial cells containing intracytoplasmic inclusions. Microscopic cutaneous lesions included epithelial cell hyperplasia with hydropic change, intraepithelial pustules, erosions, folliculitis, and dense leukocytic dermal infiltrates. Transmission was confirmed by one or more of virus isolation, polymerase chain reaction or serum neutralization tests. Significant internal lesions were not seen at necropsy.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 88%

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Experimental Deerpox Infection in Black-Tailed Deer (Odocoileus Hemionus Columbianus)

Bildfell

Thompson

Moerdyk-Schauwecker

et al. 2010

Journal of Wildlife Diseases

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“…They were compared to the corresponding sequences of three SPPV, two GTPV and four LSDV isolates retrieved from GenBank in October 2008. Three additional poxviruses were selected as outgroups for the phylogenetic study, these were: two deer poxviruses (Afonso et al, 2005) and one swine poxvirus (Massung et al, 1993).…”

Section: Methodsmentioning

confidence: 99%

Capripoxvirus G-protein-coupled chemokine receptor: a host-range gene suitable for virus animal origin discrimination

Goff

Lamien

Fakhfakh

et al. 2009

Journal of General Virology

143

142

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The genus Capripoxvirus within the family Poxviridae comprises three closely related viruses, namely goat pox, sheep pox and lumpy skin disease viruses. This nomenclature is based on the animal species from which the virus was first isolated, respectively, goat, sheep and cattle. Since capripoxviruses are serologically identical, their specific identification relies exclusively on the use of molecular tools. We describe here the suitability of the G-protein-coupled chemokine receptor (GPCR) gene for use in host-range grouping of capripoxviruses. The analysis of 58 capripoxviruses showed three tight genetic clusters consisting of goat pox, sheep pox and lumpy skin disease viruses. However, a few discrepancies exist with the classical virus-host origin nomenclature: a virus isolated from sheep is grouped in the goat poxvirus clade and vice versa. Intra-group diversity was further observed for the goat pox and lumpy skin disease virus isolates. Despite the presence of nine vaccine strains, no genetic determinants of virulence were identified on the GPCR gene. For sheep poxviruses, the addition or deletion of 21 nucleic acids (7 aa) was consistently observed in the 59 terminal part of the gene. Specific signatures for each cluster were also identified. Prediction of the capripoxvirus GPCR topology, and its comparison with other known mammalian GPCRs and viral homologues, revealed not only a classical GPCR profile in the last three-quarters of the protein but also unique features such as a longer N-terminal end with a proximal hydrophobic a-helix and a shorter serine-rich C-tail.3These authors contributed equally to this work.Two supplementary tables are available with the online version of this paper.Journal of General Virology (2009), 90, 1967-1977 DOI 10.1099 Davies, 1981Davies, , 1982Diallo & Viljoen, 2007). CaPV infections lead to similar clinical signs in sheep and goats, mainly characterized by fever, excess salivation, conjunctivitis and rhinitis with ocular and nasal discharges. These symptoms are followed by eruption of pox lesions throughout the skin. LSD is a subacute to acute cattle disease with appearance of skin nodules. During epizootics of CaPVs in domestic animals, disease in wild ungulates has never been reported (Davies, 1991), although serology and isolated cases suggests that wildlife species have a possible role in virus maintenance.CaPVs are generally considered to be host-specific, leading to outbreaks in one preferred host. This is partially true since some SPPV and GTPV isolates are capable of causing severe diseases in both sheep and goats (Davies, 1976;Kitching et al., 1989). An in-depth epidemiological investigation to specifically identify the viruses involved in acute small ruminant pox diseases cannot be achieved by serological testing alone due to the very close antigenic relationship between CaPVs, with the existence of only one serotype (Kitching et al., , 1989. The common immunogenic properties of these viruses have been used for the preparation of live attenuated vaccines that ...

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“…The tanapox virus protein 2L displays a major histocompatibility complex I-like folding (6) and can bind TNF with high affinity and inhibit its activity (7). Orthologues are found in the other members of the Yatapoxvirus genus, Yaba-like disease virus and yaba monkey tumor virus, and in the genera Suipoxvirus and Cervidpoxvirus (7,8). On the other hand, orthopoxviruses express secreted proteins with sequence similarity to the ligand binding region of cellular TNFRs (9), and these viral homologues have been included in a protein family termed viral TNFRs (vTNFRs).…”

mentioning

confidence: 99%

Comparative Biochemical and Functional Analysis of Viral and Human Secreted Tumor Necrosis Factor (TNF) Decoy Receptors

Pontejo

Alejo

Alcamı́

2015

Journal of Biological Chemistry

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Background: Poxvirus encodes up to four TNF decoy receptors (vTNFRs) that mimic etanercept, an anti-TNF drug used in the clinic. Results: vTNFRs display differences in ligand specificity and inhibitory potency. Conclusion: Some vTNFRs are more specific and potent TNF inhibitors than etanercept. Significance: This study may help to understand the role of vTNFRs in pathogenesis and improve the anti-TNF treatments.

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Genome of Deerpox Virus

Cited by 57 publications

References 68 publications

Experimental Deerpox Infection in Black-Tailed Deer (Odocoileus Hemionus Columbianus)

Experimental Deerpox Infection in Black-Tailed Deer (Odocoileus Hemionus Columbianus)

Capripoxvirus G-protein-coupled chemokine receptor: a host-range gene suitable for virus animal origin discrimination

Comparative Biochemical and Functional Analysis of Viral and Human Secreted Tumor Necrosis Factor (TNF) Decoy Receptors

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