Genome Sequence of Paenibacillus sp. Strain Aloe-11, an Endophytic Bacterium with Broad Antimicrobial Activity and Intestinal Colonization Ability

Li, Nengzhang; Xia, Tian; Xu, Yunfei; Qiu, Rong-Rong; Xiang, Heng; He, Dan; Peng, Yuanyi

doi:10.1128/jb.00087-12

Cited by 8 publications

(3 citation statements)

References 12 publications

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“…Normally, the catalytic domains of NRPS select, activate or modify the covalently tethered reaction intermediates to control the iterative chain elongation process and product release, which occur during the ribosome-independent peptide synthesis [ 104 ]. It is important to mention that one NRPS gene cluster was discovered bearing a 30-kb DNA fragment, containing four genes ( lchAA , lchAB , lchAC , and lchAD ) involved in the biosynthesis of surface-active lipopeptides, such as lichenysin [ 105 , 106 ].…”

Section: Endophytes As Potential Producers Of Peptidesmentioning

confidence: 99%

Endophytes as Producers of Peptides: An Overview About the Recently Discovered Peptides from Endophytic Microbes

Abdalla

Matasyoh

2014

Nat. Prod. Bioprospect.

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An endophyte is a fungus or bacterium that lives within a plant in a symbiotic relationship. Extensive colonization of the plant tissue by endophytes creates a barrier effect, where they outcompete and prevent pathogenic organisms from taking hold. This happens by producing secondary metabolites that inhibit the growth of the competitors or pathogens. In this way they play a very important role in the plant defence mechanisms. The metabolites produced by these endophytes fall within a wide range of classes of compounds that include peptides which are the focus of this review. Peptides are increasingly being selected for drug development because they are specific for their targets and have a higher degree of interactions. There have been quite a number of endophytic peptides reported in the recent past indicating that endophytes can be used for the production of peptide based drugs. Molecular screening for NRPS, which shows peptide producing capability, has also shown that endophytes are potential producers of peptides. The presence of NRPS also offers the possibility of genetic modifications which may generate peptides with high pharmacological activities. This review, therefore, aims to show the current status of peptides isolated from endophytic bacteria and fungi in the recent decade. Endophytes as potential sources of peptides according to NRPS studies will also be discussed.

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Section: Endophytes As Potential Producers Of Peptidesmentioning

confidence: 99%

Endophytes as Producers of Peptides: An Overview About the Recently Discovered Peptides from Endophytic Microbes

Abdalla

Matasyoh

2014

Nat. Prod. Bioprospect.

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“…Gut microbiota contains hundreds to thousands of bacteria obtained from a specific diet [16]. Li et al (2012) found that Paenibacillus sp. strain Aloe-11 had excellent intestine colonization ability and could significantly promote forage fiber degradation, thus producing antibiotic activity against many pathogenic bacteria and fungi [17].…”

Section: Introductionmentioning

confidence: 99%

“…Li et al (2012) found that Paenibacillus sp. strain Aloe-11 had excellent intestine colonization ability and could significantly promote forage fiber degradation, thus producing antibiotic activity against many pathogenic bacteria and fungi [17]. Likewise, Zheng et al (2020) found that a proportion of the intestinal microbes of potato tuber moth might be derived from bacterial endophytes in potatoes [18].…”

Section: Introductionmentioning

confidence: 99%

Dendrobium officinale Endophytes May Colonize the Intestinal Tract and Regulate Gut Microbiota in Mice

Chen

Zhu

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Dendrobium officinale is a traditional Chinese medicine for treating gastrointestinal diseases by nourishing “Yin” and thickening the stomach lining. To study whether D. officinale endophytes can colonize the intestinal tract and regulate gut microbiota in mice, we used autoclave steam sterilizing and 60Co-γ radiation to eliminate D. officinale endophytes from its juice. Then, high-throughput ITS1-ITS2 rDNA and 16S rRNA gene amplicons were sequenced to analyze the microbial community of D. officinale endophytes and fecal samples of mice after administration of fresh D. officinale juice. Sterilization of D. officinale juice by autoclaving for 40 min (ASDO40) could more effectively eliminate the D. officinale endophytes and decrease their interference on the gut microbiota. D. officinale juice could increase beneficial gut microbiota and metabolites including short-chain fatty acids. D. officinale endophytes Pseudomonas mosselii, Trichocladium asperum, Titata maxilliformis, Clonostachys epichloe, and Rhodotorula babjevae could colonize the intestinal tract of mice and modulate gut microbiota after oral administration of the juice for 28 days. Thus, the regulatory effect of D. officinale juice on gut microbiota was observed, which provides a basis for inferring that D. officinale endophytes might colonize the intestinal tract and participate in regulating gut microbiota to treat diseases. Thus, this study further provides a new approach for the treatment of diseases by colonizing plant endophytes in the intestinal tract and regulating gut microbiota.

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Bacterial endophytes: Molecular interactions with their hosts

et al. 2021

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Plant growth promotion has been found associated with plants on the surface (epiphytic), inside (endophytic), or close to the plant roots (rhizospheric). Endophytic bacteria mainly have been researched for their beneficial activities in terms of nutrient availability, plant growth hormones, and control of soil‐borne and systemic pathogens. Molecular communications leading to these interactions between plants and endophytic bacteria are now being unrevealed using multidisciplinary approaches with advanced techniques such as metagenomics, metaproteomics, metatranscriptomics, metaproteogenomic, microRNAs, microarray, chips as well as the comparison of complete genome sequences. More than 400 genes in both the genomes of host plant and bacterial endophyte are up‐ or downregulated for the establishment of endophytism and plant growth‐promoting activity. The involvement of more than 20 genes for endophytism, about 50 genes for direct plant growth promotion, about 25 genes for biocontrol activity, and about 10 genes for mitigation of different stresses has been identified in various bacterial endophytes. This review summarizes the progress that has been made in recent years by these modern techniques and approaches.

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Genome Sequence of Paenibacillus sp. Strain Aloe-11, an Endophytic Bacterium with Broad Antimicrobial Activity and Intestinal Colonization Ability

Cited by 8 publications

References 12 publications

Endophytes as Producers of Peptides: An Overview About the Recently Discovered Peptides from Endophytic Microbes

Endophytes as Producers of Peptides: An Overview About the Recently Discovered Peptides from Endophytic Microbes

Dendrobium officinale Endophytes May Colonize the Intestinal Tract and Regulate Gut Microbiota in Mice

Bacterial endophytes: Molecular interactions with their hosts

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