Genome Sequence of the Emerging Pathogen
            <i>Helicobacter canadensis</i>

Loman, Nicholas J.; Snyder, Lori; Linton, Dennis; Langdon, Rebecca R.; Lawson, Andrew; Weinstock, George M.; Wren, Brendan W.; Pallen, Mark J.

doi:10.1128/jb.00729-09

Cited by 17 publications

(16 citation statements)

References 14 publications

(10 reference statements)

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“…A similar en bloc N-glycosylation system has been discovered in Helicobacter canadensis based on genome analysis (298). Further genome analysis showed the presence of PglB orthologues in H. canadensis, H. pullorum, and H. winghamensis (333).…”

Section: Protein Glycosylationmentioning

confidence: 94%

“…En bloc N-glycosylation has so far mainly been studied in detail in Campylobacter species (77), while H. influenzae and Actinobacillus pleuropneumoniae harbor a sequential N-glycosylation mechanism (296,297). Recently, genomic analysis revealed the presence of an en bloc N-glycosylation mechanism in some Helicobacter species (298). N-glycosylation in Chlamydia trachomatis has been suggested, but information on the underlying mechanisms is lacking (299,300).…”

Section: Protein Glycosylationmentioning

confidence: 99%

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The Sweet Tooth of Bacteria: Common Themes in Bacterial Glycoconjugates

Tytgat

Lebeer

2014

Microbiol Mol Biol Rev

129

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SUMMARY Humans have been increasingly recognized as being superorganisms, living in close contact with a microbiota on all their mucosal surfaces. However, most studies on the human microbiota have focused on gaining comprehensive insights into the composition of the microbiota under different health conditions (e.g., enterotypes), while there is also a need for detailed knowledge of the different molecules that mediate interactions with the host. Glycoconjugates are an interesting class of molecules for detailed studies, as they form a strain-specific barcode on the surface of bacteria, mediating specific interactions with the host. Strikingly, most glycoconjugates are synthesized by similar biosynthesis mechanisms. Bacteria can produce their major glycoconjugates by using a sequential or an en bloc mechanism, with both mechanistic options coexisting in many species for different macromolecules. In this review, these common themes are conceptualized and illustrated for all major classes of known bacterial glycoconjugates, with a special focus on the rather recently emergent field of glycosylated proteins. We describe the biosynthesis and importance of glycoconjugates in both pathogenic and beneficial bacteria and in both Gram-positive and -negative organisms. The focus lies on microorganisms important for human physiology. In addition, the potential for a better knowledge of bacterial glycoconjugates in the emerging field of glycoengineering and other perspectives is discussed.

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Section: Protein Glycosylationmentioning

confidence: 94%

Section: Protein Glycosylationmentioning

confidence: 99%

The Sweet Tooth of Bacteria: Common Themes in Bacterial Glycoconjugates

Tytgat

Lebeer

2014

Microbiol Mol Biol Rev

129

View full text Add to dashboard Cite

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“…Based on this latter finding, the authors concluded that this mechanism of C-terminal phase variation has implications for stochastic switching of protein sequence in bacterial species that already undergo transcriptional and translational phase variation (Snyder et al 2010). Of these 29 phase-variable genes, a number may be implicated in virulence, including an Immunoglobulin A (IgA) protease, and two homologues of the vacuolating cytotoxin of H. pylori (Loman et al 2009). …”

Section: Helicobacter Canadensismentioning

confidence: 95%

“…Sequencing of the genome of H. canadensis has identified a range of virulence factors including an immunoglobulin A (IgA) protease, and two homologues of the vacuolating cytotoxin of H. pylori (Loman et al 2009). In addition, a capsular polysaccharide export locus, similar to that in C. jejuni, was identified.…”

Section: Other Helicobactersmentioning

confidence: 99%

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The Family Helicobacteraceae

et al. 2014

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Investigation of the enzymes required for the biosynthesis of an unusual formylated sugar in the emerging human pathogen Helicobacter canadensis

et al. 2021

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It is now well established that the Gram-negative bacterium, Helicobacter pylori, causes gastritis in humans. In recent years, it has become apparent that the so-called non-pylori Helicobacters, normally infecting pigs, cats, and dogs, may also be involved in human pathology via zoonotic transmission. Indeed, more than 30 species of non-pylori Helicobacters have been identified thus far. One such organism is Helicobacter canadensis, an emerging pathogen whose

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Genome Sequence of the Emerging Pathogen Helicobacter canadensis

Cited by 17 publications

References 14 publications

The Sweet Tooth of Bacteria: Common Themes in Bacterial Glycoconjugates

The Sweet Tooth of Bacteria: Common Themes in Bacterial Glycoconjugates

The Family Helicobacteraceae

Investigation of the enzymes required for the biosynthesis of an unusual formylated sugar in the emerging human pathogen Helicobacter canadensis

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