Genome wide analysis ofCyclophilingene family from rice and Arabidopsis and its comparison with yeast

Functional Classification of Skinning Injury Responsive Genes in Storage Roots of Sweetpotato

“…Studies have demonstrated the importance of many PPIases in plant biology, but no genome-wide analysis of the CYP gene family has been conducted for a legume species. CYP transcripts are commonly up-regulated in response to salt stress (Ruan et al, 2011), osmotic stress and high light condition (Kim et al, 2012), desiccation and salt stress (Ahn et al, 2010, Trivedi et al, 2012, low temperature, abscisic acid (ABA). Various CYPs have been found in cytosol, nucleus, chloroplast, secretory, and mitochondria (Mainali et al, 2014) suggesting a substantial role in a wide array of plant defense and cellular processes such as protein folding, mRNA processing, protein degradation and signal transduction which are crucial during development and stress response (Laxa et al, 2007).…”

Protein Structure–Function Paradigm in Plant Stress Tolerance

“…For these reactions, dedicated enzymes are present like protein disulfide isomerase (PDI), and immunophilins like cyclophilins and FK506 proteins. Cyclophilins are omnipresent cellular proteins conserved throughout evolution [60]. In eukaryotic systems, cyclophilins have direct or indirect roles in cell division [61], transcriptional regulation [62], protein trafficking [63], cell signaling [64,65], pre-mRNA splicing [66], molecular chaperone mechanisms [67,68], and stress tolerance [69,70].…”

Cyclophilin: A Versatile Chaperone of Biological System

“…Cyclophilins are ubiquitous proteins found to be present in all organisms ranging from bacteria to mammals [3]. Cyclophilins are involved in a wide range of cellular processes like protein folding, protein complex stabilization, cell division, protein trafficking, cell signalling, transcriptional regulation, pre-mRNA splicing and stress tolerance [4,5].…”

“…These proteins are highly conserved with respect to PPIase activity from the evolutionary point of view. There are 28 and 35 cyclophilins in rice and Arabidopsis respectively [4]. In humans, 7 major cyclophilins have been reported-hCyp18 (CypA), hCyp22 (CypB), hCypC, hCypD, hCyp40 (hCypE) and hCypNK (identified in natural killer cells).…”

“…In humans, 7 major cyclophilins have been reported-hCyp18 (CypA), hCyp22 (CypB), hCypC, hCypD, hCyp40 (hCypE) and hCypNK (identified in natural killer cells). In Saccharomyces cerevisiae, 8 cyclophilins have been identified, named Cpr1-Cpr8 [4] whereas, in Drosophila, 9 cyclophilins have been identified. The crystal structure of AtCyp38 and PiCypA from Arabidopsis thaliana and Piriformospora indica respectively, showed that it is a monomeric single domain protein and forms a canonical cyclophilin fold comprising two α-helices and eight β-strands [5,7].…”