Genome-wide analysis of microrna and mRNA expression in Anti-N-methyl-D-aspartate receptor encephalitis in vitro model

Jun, Ji Hae; Moon, Jangsup; Kim, T.J.; Lee, S.T.; Jung, Keun Hwa; Park, K.I.; Jung, Ki Young; Kim, M.H.; Chu, Kon; Lee, S.K.

doi:10.1016/j.jns.2017.08.1812

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“…Another study used an in vitro model for exploring miRNA biomarkers. The dysregulation of miRNA and mRNA expression in the in vitro anti-NMDAR encephalitis model was investigated [55]. Researchers incubated hippocampal neurons of rat pups with cerebrospinal fluid from four anti-NMDAR encephalitis patients and four negative controls.…”

Section: Micrornamentioning

confidence: 99%

Phylogenetic Analysis to Explore the Association Between Anti-NMDA Receptor Encephalitis and Tumors Based on microRNA Biomarkers

Wang

2019

Biomolecules

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MicroRNA (miRNA) is a small non-coding RNA that functions in the epigenetics control of gene expression, which can be used as a useful biomarker for diseases. Anti-NMDA receptor (anti-NMDAR) encephalitis is an acute autoimmune disorder. Some patients have been found to have tumors, specifically teratomas. This disease occurs more often in females than in males. Most of them have a significant recovery after tumor resection, which shows that the tumor may induce anti-NMDAR encephalitis. In this study, I review microRNA (miRNA) biomarkers that are associated with anti-NMDAR encephalitis and related tumors, respectively. To the best of my knowledge, there has not been any research in the literature investigating the relationship between anti-NMDAR encephalitis and tumors through their miRNA biomarkers. I adopt a phylogenetic analysis to plot the phylogenetic trees of their miRNA biomarkers. From the analyzed results, it may be concluded that (i) there is a relationship between these tumors and anti-NMDAR encephalitis, and (ii) this disease occurs more often in females than in males. This sheds light on this issue through miRNA intervention.

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Section: Micrornamentioning

confidence: 99%

Phylogenetic Analysis to Explore the Association Between Anti-NMDA Receptor Encephalitis and Tumors Based on microRNA Biomarkers

Wang

2019

Biomolecules

View full text Add to dashboard Cite

show abstract

Genome-wide analysis of microrna and mRNA expression in Anti-N-methyl-D-aspartate receptor encephalitis in vitro model

Cited by 1 publication

References 0 publications

Phylogenetic Analysis to Explore the Association Between Anti-NMDA Receptor Encephalitis and Tumors Based on microRNA Biomarkers

Phylogenetic Analysis to Explore the Association Between Anti-NMDA Receptor Encephalitis and Tumors Based on microRNA Biomarkers

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