Genome-wide association study for lactation persistency, female fertility, longevity, and lifetime profit index traits in Holstein dairy cattle

Abstract

Female fertility in Holstein cattle can decline when intense genetic selection is placed on milk production. One approach to improving fertility is to identify the genomic regions and variants affecting fertility traits and then incorporate this knowledge into selection decisions. The objectives of this study were to identify or refine the positions of the genomic regions associated with lactation persistency, female fertility traits (age at first service, cow first service to conception, heifer and cow nonreturn rates), longevity traits (herd life, indirect herd life, and direct herd life), and lifetime profit index in the North American Holstein dairy cattle population. A genome-wide association study was performed for each trait, using a single SNP (single nucleotide polymorphism) regression mixed linear model and imputed high-density panel (777k) genotypes. No associations were identified for fertility traits. Several peak regions were detected for lifetime profit index, lactation persistency, and longevity. The results overlap with previous findings and identify some novel regions for lactation persistency. Previously proposed causative and candidate genes supported by this work include DGAT1, GRINA, and CPSF1, whereas new candidate genes are SLC2A4RG and THRB. Thus, the chromosomal regions identified in this study not only confirm several previous findings but also highlight new regions that may contribute to genetic variation in lactation persistency and longevity-associated traits in dairy cattle.

GWAS and Fine-Mapping of Livability and Six Disease Traits in Holstein Cattle

“…The region around 88,868,886 bp on BTA 6 associated with mastitis is close to the GC gene with many reported QTLs associated with mastitis [17–20]. This region was also associated with cow livability in this study with QTLs involved with the length of productive life [21]. For the six regions associated with cow livability (Table 2), we found reported QTLs related to productive life, somatic cell count, immune response, reproduction, and body conformation traits [21].…”

Genome‐wide scan of selection signatures in Dehong humped cattle for heat tolerance and disease resistance

“…(Table ). Additionally, seven out of 15 were overlapping with GWAS hits in other cattle populations, such as Brahman cattle (Bolormaa et al ; Fortes et al ), beef cattle (Dias et al ) and Holstein dairy cattle (Nayeri et al ) (Table ). Overall, we consider that the number of false‐positive results is small in our study.…”

“…Moreover, ADAMTSL1 has important functions in the extracellular matrix and has been associated with gonad differentiation in the chicken embryo (Carré et al ). GWASs showed that SS18L1 and OSBPL2 were associated with lactation persistency in Holstein dairy cattle (Nayeri et al ), and SS18L1 was reported to be related to buffalo bull fertility (Verma et al ). TOX is worth noting on chromosome 14 (26 636 169 bp F ST = 0.718; 26 907 002 bp XP‐EHH = 4.173), which acts as a transcription factor and is involved in the development of puberty in tropically adapted Brahman and Nellore cattle (Fortes et al ; Camargo et al ).…”

“…The majority of selection signatures that we detected here are consistent with previous reports on selection signatures in Bangladesh zebu (Edea et al 2018 (Table 2). Additionally, seven out of 15 were overlapping with GWAS hits in other cattle populations, such as Brahman cattle (Bolormaa et al 2011;Fortes et al 2012), beef cattle (Dias et al 2017) and Holstein dairy cattle (Nayeri et al 2017) (Table 2). Overall, we consider that the number of false-positive results is small in our study.…”

Продуктивное Долголетие Коров Голштинской Породы Европейской Селекции В Условиях Промышленной Технологии

“…Продуктивное долголетие коров приобретает особое значение при ведении селекционно-племенной работы, поскольку тесно связано с темпами ремонта стада и интенсивностью подбора (Jenko et al, 2013;Jankowska et al, 2014;Gladiy et al, 2015;Khmelnichyi, 2016;Hutchison et al, 2017;De Vries, 2017). Преждевременное выбытие дойных коров не только сокращает племенные ресурсы пород, но и наносит экономический ущерб отрасли в целом, что приводит к большим экономическим потерям в иностранной валюте, которые не всегда окупаются за счет высокой продуктивности животных (Shherbatyj and Bodnar, 2013;Kitayeva, 2016;Nayeri et al, 2016). Это обусловливает актуальность проведения исследований по поиску эффективных генетико-селекционных методов увеличения продолжительности их хозяйственного использования (Polupan, 2014;Zubkova and Zvereva, 2014;Chernenko, 2014;Khmelnichyi and Vecherka, 2016;Oleshko, 2016;Clasen et al, 2016;Van Pelt et al, 2016;Kozyr et al, 2017).…”