Genome-wide DNA methylation analysis in families with multiple individuals diagnosed with schizophrenia and intellectual disability

Zhang, Shengmin; Shi, Kaiyu; Lyu, Nan; Zhang, Yunshu; Liang, Guangming; Zhang, Wufang; Wang, Xijin; Wen, Hong; Wen, Liping; Ma, Hong; Wang, Jijun; Yu, Xin; Guan, Lili

doi:10.1080/15622975.2023.2198595

Cited by 2 publications

(1 citation statement)

References 78 publications

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“…In addition, a methylome-wide analysis of DNA methylation of peripheral blood samples from 106 Chinese schizophrenia family trios, 125 hypomethylated and 112 hypermethylated regions were detected [53]. Another study demonstrated that the development of schizophrenia and intellectual disability is associated with the altered methylation levels of FYN, signal transducer and activator of transcription 3 (STAT3), Ras-related C3 botulinum toxin substrate 1 (Rac1), and nuclear receptor 4A2 (NR4A2) as well as changing function of the immune system [54]. More examples of diverse epigenetic alterations in major mental diseases have been presented elsewhere [5].…”

Section: Epigenetic Aberrations and Mental Disordersmentioning

confidence: 99%

Epigenetic Aberrations in Major Psychiatric Diseases Related to Diet and Gut Microbiome Alterations

Nohesara

Abdolmaleky

Thiagalingam

2023

Genes

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Nutrition and metabolism modify epigenetic signatures like histone acetylation and DNA methylation. Histone acetylation and DNA methylation in the central nervous system (CNS) can be altered by bioactive nutrients and gut microbiome via the gut–brain axis, which in turn modulate neuronal activity and behavior. Notably, the gut microbiome, with more than 1000 bacterial species, collectively contains almost three million functional genes whose products interact with millions of human epigenetic marks and 30,000 genes in a dynamic manner. However, genetic makeup shapes gut microbiome composition, food/nutrient metabolism, and epigenetic landscape, as well. Here, we first discuss the effect of changes in the microbial structure and composition in shaping specific epigenetic alterations in the brain and their role in the onset and progression of major mental disorders. Afterward, potential interactions among maternal diet/environmental factors, nutrition, and gastrointestinal microbiome, and their roles in accelerating or delaying the onset of severe mental illnesses via epigenetic changes will be discussed. We also provide an overview of the association between the gut microbiome, oxidative stress, and inflammation through epigenetic mechanisms. Finally, we present some underlying mechanisms involved in mediating the influence of the gut microbiome and probiotics on mental health via epigenetic modifications.

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Section: Epigenetic Aberrations and Mental Disordersmentioning

confidence: 99%

Epigenetic Aberrations in Major Psychiatric Diseases Related to Diet and Gut Microbiome Alterations

Nohesara

Abdolmaleky

Thiagalingam

2023

Genes

View full text Add to dashboard Cite

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Traversing the epigenetic landscape: DNA methylation from retina to brain in development and disease

Xu,

Fu,

Qin

et al. 2024

Front. Cell. Neurosci.

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DNA methylation plays a crucial role in development, aging, degeneration of various tissues and dedifferentiated cells. This review explores the multifaceted impact of DNA methylation on the retina and brain during development and pathological processes. First, we investigate the role of DNA methylation in retinal development, and then focus on retinal diseases, detailing the changes in DNA methylation patterns in diseases such as diabetic retinopathy (DR), age-related macular degeneration (AMD), and glaucoma. Since the retina is considered an extension of the brain, its unique structure allows it to exhibit similar immune response mechanisms to the brain. We further extend our exploration from the retina to the brain, examining the role of DNA methylation in brain development and its associated diseases, such as Alzheimer’s disease (AD) and Huntington’s disease (HD) to better understand the mechanistic links between retinal and brain diseases, and explore the possibility of communication between the visual system and the central nervous system (CNS) from an epigenetic perspective. Additionally, we discuss neurodevelopmental brain diseases, including schizophrenia (SZ), autism spectrum disorder (ASD), and intellectual disability (ID), focus on how DNA methylation affects neuronal development, synaptic plasticity, and cognitive function, providing insights into the molecular mechanisms underlying neurodevelopmental disorders.

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Genome-wide DNA methylation analysis in families with multiple individuals diagnosed with schizophrenia and intellectual disability

Cited by 2 publications

References 78 publications

Epigenetic Aberrations in Major Psychiatric Diseases Related to Diet and Gut Microbiome Alterations

Epigenetic Aberrations in Major Psychiatric Diseases Related to Diet and Gut Microbiome Alterations

Traversing the epigenetic landscape: DNA methylation from retina to brain in development and disease

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