Genome-wide investigation of transcription factors provides insights into transcriptional regulation in Plutella xylostella

Zhao, Qian; Ma, Dongna; Huang, Yuping; He, Weiyi; Li, Yiying; Vasseur, Liette; You, Minsheng

doi:10.1007/s00438-017-1389-y

Cited by 9 publications

(5 citation statements)

References 76 publications

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“…Homeobox proteins onecut are transcription factors involved in many pathways including nervous system differentiation (Nguyen et al, 2000). Several transcription factors have been associated with resistance to insecticide, as in Plutella xylostella (Zhao et al, 2018). Yet, how this particular transcription factor could be involved in insecticide resistance remains unclear.…”

Section: Discussionmentioning

confidence: 99%

A major 6 Mb superlocus is involved in pyrethroid resistance in the common bed bugCimex lectularius

Haberkorn

Henri

Delpuech

et al. 2023

Preprint

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In the last few years, the bed bug Cimex lectularius has been an increasing problem worldwide, mainly due to the development of insecticide resistance to pyrethroids. The characterization of resistance alleles is a prerequisite to improve surveillance and resistance management. To identify genomic variants associated with pyrethroid resistance in Cimex lectularius, we compared the genetic composition of two recent and resistant populations with that of two ancient-susceptible strains using a genome-wide pool-seq design. We identified a large 6 Mb "superlocus" showing particularly high genetic differentiation and association with the resistance phenotype. This superlocus contained several clustered resistance genes, and was also characterized by a high density of structural variants (inversions, duplications). The possibility that this superlocus constitute a resistance "supergene" that evolved after the clustering of alleles adapted to insecticide and after reduction in recombination is discussed.

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Section: Discussionmentioning

confidence: 99%

A major 6 Mb superlocus is involved in pyrethroid resistance in the common bed bugCimex lectularius

Haberkorn

Henri

Delpuech

et al. 2023

Preprint

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“…Transcriptional factors (TFs) function in a wide range of biological processes 34 . To determine whether the circRNAs are related to a TF factor, we compared the protein sequences of 561 parent genes of the circRNAs against those in FFTD with default parameters 35 .…”

Section: Resultsmentioning

confidence: 99%

Identification and characterization of circular RNAs in Ganoderma lucidum

Shao

Wang

Yang

et al. 2019

Sci Rep

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Circular RNAs (circRNAs) play important roles in animals, plants, and fungi. However, no circRNAs have been reported in Ganoderma lucidum. Here, we carried out a genome-wide identification of the circRNAs in G.lucidum using RNA-Seq data, and analyzed their features. In total, 250 and 2193 circRNAs were identified from strand-specific RNA-seq data generated from the polyA(−) and polyA(−)/RNase R-treated libraries, respectively. Six of 131 (4.58%) predicted circRNAs were experimentally confirmed. Across three developmental stages, 731 exonic circRNAs (back spliced read counts ≥ 5) and their parent genes were further analyzed. CircRNAs were preferred originating from exons with flanking introns, and the lengths of the flanking intron were longer than those of the control introns. A total of 200 circRNAs were differentially expressed across the three developmental stages of G. lucidum. The expression profiles of 119 (16.3%) exonic circRNAs and their parent genes showed significant positive correlations (r ≥ 0.9, q < 0.01), whereas 226 (30.9%) exonic circRNAs and their parent genes exhibited significant negative correlations (r ≤ −0.9, q < 0.01), in which 53 parent genes are potentially involved in the transcriptional regulation, polysaccharide biosynthesis etc. Our results indicated that circRNAs are present in G. lucidum, with potentially important regulatory roles.

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Section: Discussionmentioning

confidence: 99%

A major 6 Mb superlocus is involved in pyrethroid resistance in the common bed bug Cimex lectularius

Haberkorn

Henri

Delpuech

et al. 2023

Evolutionary Applications

View full text Add to dashboard Cite

In the last few years, the bed bug Cimex lectularius has been an increasing problem worldwide, mainly due to the development of insecticide resistance to pyrethroids.The characterization of resistance alleles is a prerequisite to improve surveillance and resistance management. To identify genomic variants associated with pyrethroid resistance in Cimex lectularius, we compared the genetic composition of two recent and resistant populations with that of two ancient-susceptible strains using a genomewide pool-seq design. We identified a large 6 Mb "superlocus" showing particularly high genetic differentiation and association with the resistance phenotype. This superlocus contained several clustered resistance genes and was also characterized by a high density of structural variants (inversions, duplications). The possibility that this superlocus constitutes a resistance "supergene" that evolved after the clustering of alleles adapted to insecticide and after reduction in recombination is discussed.

show abstract

Genome-wide investigation of transcription factors provides insights into transcriptional regulation in Plutella xylostella

Cited by 9 publications

References 76 publications

A major 6 Mb superlocus is involved in pyrethroid resistance in the common bed bugCimex lectularius

A major 6 Mb superlocus is involved in pyrethroid resistance in the common bed bugCimex lectularius

Identification and characterization of circular RNAs in Ganoderma lucidum

A major 6 Mb superlocus is involved in pyrethroid resistance in the common bed bug Cimex lectularius

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