Genome-wide linkage scan of quantitative traits representing symptom dimensions in multiplex schizophrenia families

Ryu, Seunghyong; Won, Hong‐Hee; Oh, Sohee; Kim, Jong-Won; Park, Taesung; Cho, Eunyoung; Cho, Youngah; Park, Dong Yeon; Lee, Yu-Sang; Kwon, Jun Soo; Hong, Kyung Sue

doi:10.1016/j.psychres.2013.08.015

Cited by 11 publications

(8 citation statements)

References 41 publications

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“…Results of the relevant clinical–biological studies have low reproducibility and are not consolidated within a single concept. Genetic markers of disorganization have been established in only few studies: association was found with loci 6p21, 6q11.2–6q14.2, 20q11, 9pter [2], 22q11 [3] and polymorphism of gene DRD2 Ser/Cys 311 [4]; other studies failed to find any significant linkage [5]. Data on environmental determinants of disorganization is even more rare.…”

Section: Introductionmentioning

confidence: 99%

Disorganization at the stage of schizophrenia clinical outcome: Clinical–biological study

et al. 2017

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Section: Introductionmentioning

confidence: 99%

Disorganization at the stage of schizophrenia clinical outcome: Clinical–biological study

et al. 2017

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“…Moreover, Chen et al [85] found strong evidence of association between "delusion factor" and SNPs of Neuregulin3 (NRG3) on chromosome 10q22-q23, a region identified in their previous genome-wide linkage analysis of schizophrenia [86].…”

Section: Neuregulin Genementioning

confidence: 99%

Are There Schizophrenia Genetic Markers and Mutations? A Systematic Review and Meta-Analyses

Cardoso¹,

Nascimento²,

Bernardo³

et al. 2017

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Background: Schizophrenia is a severe psychiatric disorder with a complex genetic factor determining its disease onset. Nevertheless, it is not clear in this mental disorder. Objective: To conduct a systematic review of articles regarding the genetic markers and mutations in schizophrenia. Methods: A systematic review of articles on genetic markers and mutations in schizophrenia, published from January 1, 2011, to September 7, 2015, on SCOPUS database was carried out. Search terms were "Genetic markers", "Mutation", and "Schizophrenia". Results: Of the 527 retrieved studies, 31 met the eligibility criteria. Genetic polymorphism, Immune-associated genes, TCF4 and ZNF804A association with microRNA, Neuregulin gene, Chromosome 13q32 and 11p15.4, genes involved in glutamatergic via schizophrenia and brain structure, appeared to be associated with the origin of schizophrenia. Conclusion: Some studies show genes involved in several pathways leading to the disease pathogenesis such as that one related with the dopaminergic and immune system, or rare alleles. Some genes present no involvement in the etiology of this mental disorder. These findings clarify the genetic complexity of schizophrenia and affirm that together, the genes have an overall effect greater than the sum of the individual effect of each gene. KeywordsSchizophrenia, Genetic Markers, Mutations, Systematic Review How to cite this paper: Cardoso, M.A.B.S., do Nascimento, T

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“…Our group performed a genome-wide linkage scan of quantitative traits targeting symptom dimensions in multiplex schizophrenia families [ 26 ]. The 15q26 locus harboring ST8SIA2 showed a linkage signal that attained the genome-wide empirical threshold for suggestive linkage with the “non-paranoid delusion factor”.…”

Section: Introductionmentioning

confidence: 99%

“…The 15q26 locus harboring ST8SIA2 showed a linkage signal that attained the genome-wide empirical threshold for suggestive linkage with the “non-paranoid delusion factor”. Interestingly, lifetime symptoms for this factor include grandiose, religious, and erotic delusions that are frequently observed in patients with schizophrenia or BD [ 26 ]. Based on these findings and previous studies of other populations indicating that ST8SIA2 is a candidate gene for both schizophrenia and BD, the current study investigated the genetic association between ST8SIA2 and schizophrenia and BD in the Korean population.…”

Section: Introductionmentioning

confidence: 99%

Association between ST8SIA2 and the Risk of Schizophrenia and Bipolar I Disorder across Diagnostic Boundaries

et al. 2015

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BackgroundFindings from family studies and recent genome-wide association studies have indicated overlap in the risk genes between schizophrenia and bipolar disorder (BD). After finding a linkage between the ST8SIA2 (ST8 alpha-N-acetyl-neuraminide alpha-2, 8-sicalyltransferase 2 gene) locus (15q26) and mixed families with schizophrenia and BD, several studies have reported a significant association between this gene and schizophrenia or BD. We investigated the genetic association between ST8SIA2 and both schizophrenia and BD in the Korean population.MethodsA total of 582 patients with schizophrenia, 339 patients with BD, and 502 healthy controls were included. Thirty-one tag single nucleotide polymorphisms (SNPs) across the ST8SIA2 region and three other SNPs showing significant associations in previous studies were genotyped. The associations were evaluated by logistic regression analysis using additive, dominant, and recessive genetic models.ResultsFourteen of 34 SNPs showed a nominally significant association (p < 0.05) with at least one diagnostic group. These association trends were strongest for the schizophrenia and combined schizophrenia and bipolar I disorder (BD-I) groups. The strongest association was observed in rs11637898 for schizophrenia (p = 0.0033) and BD-I (p = 0.0050) under the dominant model. The association between rs11637898 and the combined schizophrenia and BD-I group (p = 0.0006, under the dominant model) remained significant after correcting for multiple testing.DiscussionWe identified a possible role of ST8SIA2 in the common susceptibility of schizophrenia and BD-I. However, no association trend was observed for bipolar II disorder. Further efforts are needed to identify a specific phenotype associated with this gene crossing the current diagnostic categories.

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Genome-wide linkage scan of quantitative traits representing symptom dimensions in multiplex schizophrenia families

Cited by 11 publications

References 41 publications

Disorganization at the stage of schizophrenia clinical outcome: Clinical–biological study

Disorganization at the stage of schizophrenia clinical outcome: Clinical–biological study

Are There Schizophrenia Genetic Markers and Mutations? A Systematic Review and Meta-Analyses

Association between ST8SIA2 and the Risk of Schizophrenia and Bipolar I Disorder across Diagnostic Boundaries

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