Genome-wide scan of resistin mRNA expression in omental adipose tissue of baboons

Tejero, Maria Elizabeth; Cole, Shelley A.; Cai, Guowen; Peebles, Kyle W.; Freeland‐Graves, Jeanne H.; Cox, Laura A.; Mahaney, Michael C.; Rogers, Jeffrey; VandeBerg, John L.; Blangero, John; Comuzzie, Anthony G.

doi:10.1038/sj.ijo.0802699

Cited by 13 publications

(15 citation statements)

References 49 publications

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“…In both humans and baboons the metabolic response to an increase in body weight is characterized by augmentation of body fat percentage, circulating levels of insulin, insulin resistance, glucose, lipids and lower levels of adiponectin (Banks et al, 2003;Comuzzie et al, 2003;Tejero et al, 2004;Chavez et al, 2008). The baboon resistin (RETN) cDNA sequence is very similar to the reported human sequence (96% identical) (Tejero et al, 2005). Circulating levels of this protein are similar between the two species.…”

Section: Introductionsupporting

confidence: 54%

“…Circulating levels of this protein are similar between the two species. As observed in some human studies, resistin is expressed in baboon adipose tissue and mononuclear cells, and is not associated with body weight (Tejero et al, 2004(Tejero et al, , 2005.…”

Section: Introductionmentioning

confidence: 71%

“…Circulating levels of human resistin protein and RETN mRNA expression in baboon omental adipose tissue are both heritable, (41 and 24%, respectively) (Tejero et al, 2005;Menzhagi et al, 2006). Previously, our group identified a significant logarithm of odds (LOD) score of 3.8 on chromosome 19p13 for RETN mRNA levels in omental adipose tissue of baboons (Papio hamadryas), indicating that the gene or genes influencing this trait are located in this chromosomal region (Tejero et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…Previously, our group identified a significant logarithm of odds (LOD) score of 3.8 on chromosome 19p13 for RETN mRNA levels in omental adipose tissue of baboons (Papio hamadryas), indicating that the gene or genes influencing this trait are located in this chromosomal region (Tejero et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Cross-species replication of a resistin mRNA QTL, but not QTLs for circulating levels of resistin, in human and baboon

et al. 2008

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Section: Introductionsupporting

confidence: 54%

Section: Introductionmentioning

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cross-species replication of a resistin mRNA QTL, but not QTLs for circulating levels of resistin, in human and baboon

et al. 2008

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“…The adipocyte-derived hormone resistin was originally identified in connection with allergic pulmonary inflammation in mice, but has received wider attention for its role in insulin resistance. Although not all human studies agree, there is evidence that resistin influences obesity, insulin sensitivity, and subclinical inflammation in our species (reviewed in [22]). UBL5, also known as BEACON, has drawn attention for its differential expression in lean and obese Psammomys obesus, an animal model of the metabolic syndrome.…”

Section: Discussionmentioning

confidence: 93%

Quantitative trait locus on Chromosome 19 for circulating levels of intercellular adhesion molecule-1 in Mexican Americans

et al. 2007

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Circulating soluble intercellular adhesion molecule-1 (sICAM-1) is a biochemical marker of inflammation. We performed variance-components-based quantitative genetic analyses in SOLAR of sICAM-1 in 1170 individuals from Mexican American families in the San Antonio Family Heart Study. The trait is heritable (h 2 = 0.50±0.06, P<10 -6 ). Multipoint linkage analysis using a ∼10-cM microsatellite map revealed a region on Chromosome 19p near marker D19S586 showing strong evidence of linkage for sICAM-1 (empirically adjusted univariate-equivalent LOD = 4.95), coincident with the structural gene ICAM1. This region has been identified previously as a QTL for inflammatory, autoimmune, and metabolic syndrome traits. There is significant evidence (P=0.0023) of locus heterogeneity for sICAM-1 in this sample: a subset of pedigrees contributes most of the linkage signal for sICAM-1 on Chromosome 19, suggesting a logical focus for future genetic dissection of the trait.

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Heritability of brain volume, surface area and shape: An MRI study in an extended pedigree of baboons

Rogers

Kochunov

Lancaster³

et al. 2007

Human Brain Mapping

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To evaluate baboons (Papio hamadryas) as a primate model for the study of the genetic control of brain size and internal structure, we performed high resolution (<500 microm) magnetic resonance imaging on 109 pedigreed baboons. Quantitative genetic analysis of these MR images using a variance components approach indicates that native (untransformed) brain volume exhibits significant heritability among these baboons (h(2) = 0.52, P = 0.0049), with age and sex also accounting for substantial variation. Using global spatial normalization, we transformed all images to a standard population-specific reference, and recalculated the heritability of brain volume. The transformed images generated heritability estimates of h(2) = 0.82 (P = 0.00022) for total brain volume, h(2) = 0.86 (P = 0.0006) for cerebral volume, h(2) = 0.73 (P = 0.0069) for exposed surface area of the cerebrum and h(2) = 0.67 (P = 0.01) for gray matter volume. Regional differences in the genetic effects on brain structure were calculated using a voxel-based morphometry (VBM) approach. This analysis of regional variation shows that some areas of motor cortex and the superior temporal gyrus show relatively high heritability while other regions (e.g. superior parietal cortex) exhibit lower heritability. The general pattern of regional differences is similar to that observed in previous studies of humans. The present study demonstrates that there is substantial genetic variation underlying individual variation in brain size and structure among Papio baboons, and that broad patterns of genetic influence on variation in brain structure may be similar in baboons and humans.

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Genome-wide scan of resistin mRNA expression in omental adipose tissue of baboons

Cited by 13 publications

References 49 publications

Cross-species replication of a resistin mRNA QTL, but not QTLs for circulating levels of resistin, in human and baboon

Cross-species replication of a resistin mRNA QTL, but not QTLs for circulating levels of resistin, in human and baboon

Quantitative trait locus on Chromosome 19 for circulating levels of intercellular adhesion molecule-1 in Mexican Americans

Heritability of brain volume, surface area and shape: An MRI study in an extended pedigree of baboons

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