Genome-wide scanning for CHD1L gene in papillary thyroid carcinoma complicated with type 2 diabetes mellitus

Kang, Yue; Li, J J; Sun, Jingxue; Wei, Jiaxing; Ding, Chao; Shi, Chao; Wu, Gang; Li, K; F, Y; Sun, Yao; Qiao, Hong

doi:10.1007/s12094-021-02656-z

Cited by 4 publications

(3 citation statements)

References 31 publications

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“…Long-term abnormal metabolism of blood glucose and blood lipids can easily lead to lesions in different organ systems of patients, which further serves as a common risk factor for cancer lesions [ 8 ]. Thyroid cancer is a common clinical endocrine tumor, and its incidence has been on a rise in recent years, yet the clinical pathogenesis of thyroid cancer remains unclear [ 9 ]. Clinical studies have shown that the incidence of thyroid cancer in patients with type 2 diabetes can be 8 times higher than that in healthy individuals.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Changes in Blood Glucose and Blood Lipid Levels and the Risk of Thyroid Cancer in Patients with Type 2 Diabetes Mellitus

et al. 2023

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Objective. To investigate the relationship between changes in blood glucose and blood lipid levels and the risk of thyroid cancer in patients with type 2 diabetes mellitus. Methods. A total of 159 patients with type 2 diabetes who were treated in our hospital between June 2018 and February 2021 were recruited and assigned into the observation group, including 136 patients with type 2 diabetes without thyroid cancer (nonthyroid cancer group) and 23 patients with type 2 diabetes complicated with thyroid cancer (thyroid cancer group), and 120 healthy subjects during the same period were selected as the control group. Glycated hemoglobin (HbAlc), total cholesterol (TC), triacylglycerol (TG), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C) were detected and compared. Pearson’s method was conducted to analyze the correlation between serum HbAlc level and TC, TG, HDL-C, and LDL-C levels in patients with type 2 diabetes mellitus; multivariate logistic regression analysis was performed to analyze the influencing factors of thyroid cancer in patients with type 2 diabetes mellitus. Results. The serum HbAlc level and the incidence of thyroid cancer in patients with type 2 diabetes mellitus in the observation group were significantly higher than those in the control group ( P < 0.05 ). The levels of TC, TG, and LDL-C in patients with type 2 diabetes mellitus in the observation group were significantly higher than those in the control group, and the level of HDL-C was significantly lower than that in the control group ( P < 0.05 ). The correlation analysis showed that serum HbAlc levels in patients with type 2 diabetes were positively correlated with TC and TG levels and negatively correlated with HDL-C levels ( P < 0.05 ) and not correlated with LDL-C levels ( P > 0.05 ). Compared with the type 2 diabetes patients without thyroid cancer, the serum HbAlc, TC, and TG levels of the patients with type 2 diabetes mellitus in the thyroid cancer group were significantly higher, and the levels of HDL-C were significantly lower ( P < 0.05 ). There was no significant change in the level of LDL-C ( P > 0.05 ). Multivariate logistic regression analysis showed that serum HbAlc, TC, and TC levels were all risk factors for thyroid cancer in patients with type 2 diabetes mellitus ( P < 0.05 ), while serum HDL-C level was a protective factor for thyroid cancer in patients with type 2 diabetes mellitus ( P < 0.05 ). Conclusion. Thyroid cancer in type 2 diabetes patients may be linked to elevated levels of blood HbAlc, TC, and TG. HbAlc may raise the risk of thyroid cancer in type 2 diabetes patients by modulating blood lipid levels, which might serve as a marker to assess the risk of thyroid cancer in type 2 diabetes mellitus patients. However, since this study did not conduct in vitro and in vivo experiments, how HbAlc affects the pathogenesis of thyroid cancer has not been described in this study, which is also our future research direction. It is expected to provide new ideas for the prevention and treatment of thyroid cancer.

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Section: Discussionmentioning

confidence: 99%

Relationship between Changes in Blood Glucose and Blood Lipid Levels and the Risk of Thyroid Cancer in Patients with Type 2 Diabetes Mellitus

et al. 2023

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“…In the included studies, the most common complications in the MWA group were transient hoarseness or choking after drinking water, which mainly occurred because the target nodule ablation was close to the dorsal capsule, the "liquid barrier" was insufficient, or during the puncture process (39). If the gland and surrounding tissue are squeezed or the ablation time is too long, the "liquid isolation zone" shrinks, and thermal damage leads to nerve damage.…”

Section: Discussionmentioning

confidence: 99%

The efficacy and safety of microwave ablation versus conventional open surgery for the treatment of papillary thyroid microcarcinoma: a systematic review and meta-analysis

Wang¹,

Jiang²,

Liu³

et al. 2022

Gland Surg

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Background: Microwave ablation (MWA) technology has been applied to the treatment of papillary thyroid microcarcinoma (PTMC); however, its use as an alternative to conventional open surgery (OS) remains controversial, because it belongs to non-tumor radical treatment. Our article sought to compare the efficacy and safety of MWA and OS in the treatment of PTMC.Methods: We searched seven databases for studies evaluating the treatment of patients with PTMC using MWA as intervention group and OS as control group, the main outcome contained intra-operative, postoperative and follow-up outcomes. Review Manager 5.4 was used to estimate the effects of the results of the included articles and Cochrane Risk of Bias 2.0 was used to assess the risk of bias. The data were pooled to calculate the mean differences (MD) with 95% confidence intervals (CIs) for the continuous data and the odds ratio (OR) with 95% CIs for the dichotomous data.Results: A total of 13 studies, comprising 1,088 and 1,081 patients in the MWA and OS groups, respectively, were identified that compared the results of MWA to OS in the treatment of PTMC. All of the articles were at low risk of bias. There were no differences in terms of the recurrence rate (OR =0.80, 95% CI: 0.37 to 1.77; P=0.59) or lymph node metastasis (OR =0.71, 95% CI: 0.26 to 1.95; P=0.51) between the 2 groups. However, compared to the OS group, the MWA group had a shorter operation time (MD =-44.

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“…Gratifyingly, TDM displayed superior performance (GSE33630: 1.000; GSE53157: 1.000; GSE60542: 0.926; GSE65144: 0.904; GSE3467: 1.000; GSE3678: 1.000; GSE6004: 1.000) (Figure 4E-H, Supplementary Figure S2A-C). Furthermore, a total of 20 published indicators (models and biomarkers) for TC diagnosis [12][13][14][15][16][17][18][19][20][21][22][23][24] were retrieved and compared with TDM in four datasets (GSE33630, GSE53157, GSE60542, GSE65144)(Figure 4I). Of note, TDM exhibited the highest AUC values and outperformed the other 20 indicators in all cohorts.…”

Section: Construction and Validation Of A Robust Thyroid Diagnostic M...mentioning

confidence: 99%

Bulk and Single-cell transcriptome profiling reveal T cell-based diagnosis model and tumor microenvironment infiltration characterization in Thyroid Cancer

Zhang

et al. 2023

Preprint

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Background Considerable suspicious thyroid nodules still cannot be diagnosed after the preoperative fine needle aspiration, thereby novel diagnostic tools are imperative for clinical practice.Methods 884 thyroid cancer patients were enrolled from eight independent datasets and 29,561 cells were obtained from a single-cell RNA dataset. 20 published transcriptome signatures were retrieved.Results We comprehensively identified the significantly increased proportion of T cells in thyroid cancer via single-cell RNA analysis. Combined with the bulk expression data, 17 T cell-related genes were screened out. The thyroid diagnostic model (TDM), a consensus machine-learning-derived model, was determined and compared with 20 published transcriptome signatures. TMD displays stable and powerful performance with excellent AUCs in seven cohorts (1.000, 1.000, 1.000, 1.000, 1.000, 0.926, 0.904). Notably, the high-risk group is typically featured by high-immune states and cell invasiveness. Besides, the tumor immune microenvironment characterized high-risk group with high infiltration of antigen presentation-related cells, increased expression of antigen presentation-related molecules, and some co-inhibitor molecules, indicating enhanced immune activation and sensitivity to immunotherapy.Conclusion TDM provided an attractive potential approach for identifying thyroid cancer at high risk in an early stage and deciphering its immune microenvironment to optimize clinical management for patients with thyroid cancer.

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Genome-wide scanning for CHD1L gene in papillary thyroid carcinoma complicated with type 2 diabetes mellitus

Cited by 4 publications

References 31 publications

Relationship between Changes in Blood Glucose and Blood Lipid Levels and the Risk of Thyroid Cancer in Patients with Type 2 Diabetes Mellitus

Relationship between Changes in Blood Glucose and Blood Lipid Levels and the Risk of Thyroid Cancer in Patients with Type 2 Diabetes Mellitus

The efficacy and safety of microwave ablation versus conventional open surgery for the treatment of papillary thyroid microcarcinoma: a systematic review and meta-analysis

Bulk and Single-cell transcriptome profiling reveal T cell-based diagnosis model and tumor microenvironment infiltration characterization in Thyroid Cancer

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