Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients

Kennedy, Richard B.; Ovsyannikova, Inna G.; Haralambieva, Iana H.; Lambert, Nathaniel D.; Pankratz, V. Shane

doi:10.1007/s00251-014-0776-3

Cited by 41 publications

(34 citation statements)

References 36 publications

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“…Further genetic factors are polymorphisms in pattern recognition receptors (PRRs), such as Toll-like receptor (TLR) or RIG-like receptor (RLR) genes (192)(193)(194)(195) (Table 3). In addition, many single-nucleotide polymorphisms (SNPs) in other genes, for example, those coding for cytokines or cytokine, viral, or vitamin receptors, are also associated with variations in vaccine responses (182,190,192,193,(196)(197)(198)(199)(200)(201)(202)(203)(204)(205)(206)(207)(208)(209)(210)(211) (Table 3). Further, different expression levels of genes also influence vaccine responses.…”

Section: Lower Vaccine Responses In Neonates and Young Infantsmentioning

confidence: 99%

Factors That Influence the Immune Response to Vaccination

2019

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SUMMARYThere is substantial variation between individuals in the immune response to vaccination. In this review, we provide an overview of the plethora of studies that have investigated factors that influence humoral and cellular vaccine responses in humans. These include intrinsic host factors (such as age, sex, genetics, and comorbidities), perinatal factors (such as gestational age, birth weight, feeding method, and maternal factors), and extrinsic factors (such as preexisting immunity, microbiota, infections, and antibiotics). Further, environmental factors (such as geographic location, season, family size, and toxins), behavioral factors (such as smoking, alcohol consumption, exercise, and sleep), and nutritional factors (such as body mass index, micronutrients, and enteropathy) also influence how individuals respond to vaccines. Moreover, vaccine factors (such as vaccine type, product, adjuvant, and dose) and administration factors (schedule, site, route, time of vaccination, and coadministered vaccines and other drugs) are also important. An understanding of all these factors and their impacts in the design of vaccine studies and decisions on vaccination schedules offers ways to improve vaccine immunogenicity and efficacy.

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Section: Lower Vaccine Responses In Neonates and Young Infantsmentioning

confidence: 99%

Factors That Influence the Immune Response to Vaccination

2019

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“…Indeed, Kennedy et al detected single nucleotide polymorphisms that are associated with variations in interferon-γ secretion and map near the genes encoding butyrophilin and cytokine receptors [26,27].…”

Section: Discussionmentioning

confidence: 99%

Changes of Antibody Associated with Cell-Mediated Immunity in College Students During Two Years after Rubella Vaccination

Terada¹,

Hagihara²,

Tanaka³

et al. 2017

J Vaccines Vaccin

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Objective: This study measured cell-mediated immunity (CMI) and serum antibody levels against rubella to clarify antibody changes associated with CMI during 2 years after vaccination. Methods:The study subjects were 64 college students in two groups: 38 subjects who (having exhibited hemagglutination-inhibition (HI) anti-rubella antibody titers of ≤ 1:16) had been vaccinated with a rubella vaccine 2 years previously (Group 1); and 26 subjects who (having exhibited HI titers ≥ 1:32) had not been vaccinated 2 years previously (Group 2). All students were tested for IgG antibody levels (by enzyme-linked immunosorbent assay) and CMI (by interferon-γ (IFN-γ release assay). Results:The IgG antibody and IFN-γ values decreased significantly in Group 1 during the 2 years postvaccination, while antibody titers in Group 2 did not decrease over this interval. The proportion of Group-1 individuals with HI antibody titers ≤ 1:16 increased to 27/38 (71.1%) at two years following vaccination, compared with 6/26 (23.1%) in Group 2. No correlation of IgG antibody titers was observed in Group 1 between one month and two years after vaccination. However, a strong correlation (r=0.85, p<0.00001) was detected in Group 2 between two years ago and the present. The correlation of IFN-γ values in Group 1 between one month and two years after vaccination was 0.614 (p<0.00005). When the subjects were classified by CMI status, the numbers of individuals who were intermediate and negative for IgG antibody at two years after vaccination were 1 and 0 of 13 subjects, 3 and 1 of 9 subjects, and 3 and 2 of 16 subjects in Group 1, respectively, while the antibody-positive status was maintained in all subjects in Group 2. Conclusion:The IgG antibody and IFN-γ values decreased in distinct ways during the 2 years of the study; the persistence of the seropositivity was associated with CMI status.

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“…A number of GWAS studies have been undertaken or are underway for childhood vaccines including MMR ( 43 ). In this study, SNPs in two genes were associated with the magnitude of IFN-g responses to rubella vaccination in school age children.…”

Section: Gene Identificationmentioning

confidence: 99%

The Genetic Regulation of Infant Immune Responses to Vaccination

Newport

2015

Front. Immunol.

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A number of factors are recognized to influence immune responses to vaccinations including age, gender, the dose, and quality of the antigen used, the number of doses given, the route of administration, and the nutritional status of the recipient. Additionally, several immunogenetic studies have identified associations between polymorphisms in genes encoding immune response proteins, both innate and adaptive, and variation in responses to vaccines. Variants in the genes encoding Toll-like receptors, HLA molecules, cytokines, and cytokine receptors have associated with heterogeneity of responses to a wide range of vaccines including measles, hepatitis B, influenza A, BCG, Haemophilus influenzae type b, and certain Neisseria meningitidis serotypes, amongst others. However, the vast majority of these studies have been conducted in older children and adults and there are very few data available from studies conducted in infants. This paper reviews the evidence to date that host genes influencing vaccines responses in these older population and identifies a large gap in our understanding of the genetic regulation of responses in early life. Given the high mortality from infection in early life and the challenges of developing vaccines that generate effective immune responses in the context of the developing immune system further research on infant populations is required.

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Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients

Cited by 41 publications

References 36 publications

Factors That Influence the Immune Response to Vaccination

Factors That Influence the Immune Response to Vaccination

Changes of Antibody Associated with Cell-Mediated Immunity in College Students During Two Years after Rubella Vaccination

The Genetic Regulation of Infant Immune Responses to Vaccination

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