Genomewide association study of body weight traits in Baluchi sheep

Gholizadeh, Mohsen; Rahimi-Mianji, Ghodrat; Nejati‐Javaremi, A.

doi:10.1007/s12041-015-0469-1

Cited by 39 publications

(19 citation statements)

References 16 publications

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“…In addition, we found that the candidate body weight genes, identified in this study, had poor repeatability, compared with previously reported GWAS results for sheep body weight [4,7,10,32]. In previous sheep body weight GWAS, variation detection was performed using BeadChips, so only a very limited number of mutations were detected.…”

Section: Discussioncontrasting

confidence: 60%

Genome-Wide Association Study of Body Weight Traits in Chinese Fine-Wool Sheep

Yuan

et al. 2020

Animals

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Body weight is an important economic trait for sheep and it is vital for their successful production and breeding. Therefore, identifying the genomic regions and biological pathways that contribute to understanding variability in body weight traits is significant for selection purposes. In this study, the genome-wide associations of birth, weaning, yearling, and adult weights of 460 fine-wool sheep were determined using resequencing technology. The results showed that 113 single nucleotide polymorphisms (SNPs) reached the genome-wide significance levels for the four body weight traits and 30 genes were annotated effectively, including AADACL3, VGF, NPC1, and SERPINA12. The genes annotated by these SNPs significantly enriched 78 gene ontology terms and 25 signaling pathways, and were found to mainly participate in skeletal muscle development and lipid metabolism. These genes can be used as candidate genes for body weight in sheep, and provide useful information for the production and genomic selection of Chinese fine-wool sheep.

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Section: Discussioncontrasting

confidence: 60%

Genome-Wide Association Study of Body Weight Traits in Chinese Fine-Wool Sheep

Yuan

et al. 2020

Animals

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“…(Fariello et al, 2014). In a GWAS study, Gholizadeh et al (2015) identified significant association between a single SNP located in the SYNE1 gene on chromosome 8 with yearling weight in Baluchi sheep found across southwest Pakistan, eastern Iran and southern Afghanistan. Using different approaches, multiple selection sweep regions spanning several candidate genes relating to various traits (immunity, nervous and endocrine system development, metabolism, thermo-regulation, reproduction, etc.…”

Section: Detection Of Signatures Of Selection and Use Of Molecular Mamentioning

confidence: 99%

Invited review: Genomic selection for small ruminants in developed countries: how applicable for the rest of the world?

Mrode

Tarekegn

Mwacharo³

et al. 2018

Animal

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Improved management and use of estimated breeding values in breeding programmes, have resulted in rapid genetic progress for small ruminants (SR) in Europe and other developed countries. The development of single nucleotide polymorphisms chips opened opportunities for genomic selection (GS) in SR in these countries. Initially focused on production traits (growth and milk), GS has been extended to functional traits (reproductive performance, disease resistance and meat quality). The GS systems have been characterized by smaller reference populations compared with those of dairy cattle and consisting mostly of cross- or multi-breed populations. Molecular information has resulted in gains in accuracy of between 0.05 and 0.27 and proved useful in parentage verification and the identification of QTLs for economically important traits. Except for a few established breeds with some degree of infrastructure, the basic building blocks to support conventional breeding programmes in small holder systems are lacking in most developing countries. In these systems, molecular data could offer quick wins in undertaking parentage verification and genetic evaluations using G matrix, and determination of breed composition. The development of next-generation molecular tools has prompted investigations on genome-wide signatures of selection for mainly adaptive and reproduction traits in SR in developing countries. Here, the relevance of the developments and application of GS and other molecular tools in developed countries to developing countries context is examined. Worth noting is that in the latter, the application of GS in SR will not be a 'one-size fits all' scenario. For breeds with some degree of conventional genetic improvement, classical GS may be feasible. In small holder systems, where production is key, community-based breeding programmes can provide the framework to implement GS. However, in fragile growth systems, for example those found in marginal environments, innovative GS to maximize adaptive diversity will be required. A cost-benefit analysis should accompany any strategy of implementing GS in these systems.

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“…Meanwhile, a number of genetic variants and signaling pathways have also been identified in these studies. Gholizadeh et al performed a GWAS for growth traits in Baluchi sheep using the Illumina Ovine SNP50 BeadChip and detected candidate genes associated with weight at various ages [28] . For example, STRBP and TRAMIL1 affected bodyweight at the 53 and 83 week stages; DAAM1 and APIP had a central role in controlling weaning weight; PHF15, PRSS12 and MAN1A1 genes were involved in the six-month-weight; SYNE1, WAPAL and DAAM1 genes were associated with the yearling weight [28] .…”

Section: Growth Traitsmentioning

confidence: 99%

“…Gholizadeh et al performed a GWAS for growth traits in Baluchi sheep using the Illumina Ovine SNP50 BeadChip and detected candidate genes associated with weight at various ages [28] . For example, STRBP and TRAMIL1 affected bodyweight at the 53 and 83 week stages; DAAM1 and APIP had a central role in controlling weaning weight; PHF15, PRSS12 and MAN1A1 genes were involved in the six-month-weight; SYNE1, WAPAL and DAAM1 genes were associated with the yearling weight [28] . Also, Matika et al conducted a GWAS using the Illumina Ovine SNP50 BeadChip, and identified a QTL on chromosome 6, surrounded by a number of genes (e.g., OST/SPP1, MEPE, IBSP, NCAPG and LCORL) affecting bone traits [16] .…”

Section: Growth Traitsmentioning

confidence: 99%

Recent advances in understanding genetic variants associated with economically important traits in sheep (Ovis aries) revealed by high-throughput screening technologies

Xu¹,

Li²

2017

Front. Agr. Sci. Eng.

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Sheep are one of the most economically important domesticated animals for human society. However, genetic improvements for the key traits associated with meat, growth, milk, wool, reproduction, horns and tails progress slowly using conventional crossbreeding methods. With the development and utilization of highthroughput screening technologies over the last decade, a list of functional genes and genetic variants associated with these traits has been identified. This review covers recent genome-wide studies on sheep productive traits using high-throughput screening technologies, including those based on single-nucleotide polymorphisms and copy number variants at the whole-genome level (e.g., genome-wide association studies), transcriptome and DNA methylation sequences. Additionally, comprehensive information on functional genes and genetic variants associated with economically important traits in sheep is provided.

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Genomewide association study of body weight traits in Baluchi sheep

Cited by 39 publications

References 16 publications

Genome-Wide Association Study of Body Weight Traits in Chinese Fine-Wool Sheep

Genome-Wide Association Study of Body Weight Traits in Chinese Fine-Wool Sheep

Invited review: Genomic selection for small ruminants in developed countries: how applicable for the rest of the world?

Recent advances in understanding genetic variants associated with economically important traits in sheep (Ovis aries) revealed by high-throughput screening technologies

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