Genomewide association study to detect QTL for twinning rate in Baluchi sheep

Gholizadeh, Mohsen; Rahimi-Mianji, Ghodrat; Nejati‐Javaremi, A.; Koning, Dirk-Jan de; Jonas, Elisabeth

doi:10.1007/s12041-014-0372-1

Cited by 25 publications

(19 citation statements)

References 16 publications

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“…To date, a set of genes and QTLs affecting these traits in sheep were reported by GWAS. For example, the prolactin receptor gene was reported as a key regulator of mammalian reproduction, thyroid stimulating hormone receptor as having a pivotal role in metabolic regulation and control of reproduction, and growth differentiation factor 9 (GDF9) as a strong candidate gene for increased ovulation rate/litter size [11,[49][50][51] . Moreover, an X-chromosomal locus close to the BMP15 gene was identified in highly prolific and normal ewes by GWAS, and two novel mutations in the BMP15 gene were found to be associated with increased litter size and ovulation rate, resulting in an atypically high prolificacy [52] .…”

Section: Reproductive Traitsmentioning

confidence: 99%

“…For example, bone morphogenetic protein receptor 1B (BMPR1B) encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases that belongs to the transforming growth factor b (TGFb) receptor family. Through QTL fine mapping and deep-sequencing approaches, BMPR1B has been demonstrated to be a strong candidate gene for the prolificacy traits in sheep [57,87,88] . Also, BMPR1B knockout mice showed irregular estrous cycles and an impaired pseudo-pregnancy response; meanwhile, the level of mRNA for cyclooxygenase 2, an enzyme required for cumulus expansion, was increased [89] .…”

Section: Box 1: Workflow Of Identification Validation and Applicatiomentioning

confidence: 99%

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Recent advances in understanding genetic variants associated with economically important traits in sheep (Ovis aries) revealed by high-throughput screening technologies

Xu¹,

Li²

2017

Front. Agr. Sci. Eng.

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Sheep are one of the most economically important domesticated animals for human society. However, genetic improvements for the key traits associated with meat, growth, milk, wool, reproduction, horns and tails progress slowly using conventional crossbreeding methods. With the development and utilization of highthroughput screening technologies over the last decade, a list of functional genes and genetic variants associated with these traits has been identified. This review covers recent genome-wide studies on sheep productive traits using high-throughput screening technologies, including those based on single-nucleotide polymorphisms and copy number variants at the whole-genome level (e.g., genome-wide association studies), transcriptome and DNA methylation sequences. Additionally, comprehensive information on functional genes and genetic variants associated with economically important traits in sheep is provided.

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Section: Reproductive Traitsmentioning

confidence: 99%

Section: Box 1: Workflow Of Identification Validation and Applicatiomentioning

confidence: 99%

Recent advances in understanding genetic variants associated with economically important traits in sheep (Ovis aries) revealed by high-throughput screening technologies

Xu¹,

Li²

2017

Front. Agr. Sci. Eng.

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“…Until now, several attempts have been made to map quantitative trait loci or detect causal mutations responsible for phenotypic variation of reproduction in sheep employing techniques such as genome‐wide association studies (Gholizadeh, Rahimi‐Mianji, Nejati‐Javaremi, Koning, & Jonas, ; Lv et al, ; Wang et al, ), RNA‐Seq analyses (Chen et al, ; Hu et al, ) and methylated DNA immunoprecipitation sequencing (Cao et al, ). In the study herein, we applied nucleotide diversity (Pi) and F ST statistical methods to compare the whole genome sequences of the Romanov sheep with those of the Assaf, Awassi, Cambridge and British du cher breeds to explore the genetic mechanisms underlying variation in litter size and to find novel candidate genes in the genomic regions under selection.…”

Section: Introductionmentioning

confidence: 99%

Whole genome sequence analysis to detect signatures of positive selection for high fecundity in sheep

Nosrati

Nanaei

Ghanatsaman

et al. 2018

Reprod Domestic Animals

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ContentsOvulation rate and prolificacy are the most important reproductive traits that have major impact on the efficiency of lamb meat production. Here, we compared the whole genomes of the Romanov sheep, known as one of the high prolific breeds, and four other sheep breeds namely Assaf, Awassi, Cambridge and British du cher, to identify genetic mechanisms underlying prolificacy in sheep. Selection signature analysis revealed 637 and 477 protein-coding genes under positive selection from F ST and nucleotide diversity (Pi) statistics, respectively. Further analysis showed that several candidate genes including LEPR, PDGFRL and KLF5 genes are involved in sheep prolificacy. The identified candidate genes in the selected regions are novel and provide new insights into the genetic mechanisms underlying prolificacy in sheep and can be useful in sheep breeding programmes to develop improved breeds for high reproductive efficiency. K E Y W O R D S comparative genomics, positive selection, reproductive traits, Romanov sheep, whole genome sequence | 359 NOSRATI eT Al.

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“…In that study, sequencing of BMP15 gene showed two novel mutations called FecX Gr and FecX O , responsible for highly prolific phenotype in Grivette and Olkuska breeds, respectively (Demars et al., ). Another genomewide association study was conducted to detect QTLs for twinning rate; a number of significant and suggestive associated markers indicating three different QTL regions on chromosomes 10 and 15 were found in Iranian Baluchi sheep (Gholizadeh, Rahimi‐Mianji, Nejati‐Javaremi, De Koning, & Jonas, ). This study was a novel detection of the fragments involved in sheep prolificacy in this region and is another evidence for the complex genetic nature for twinning in sheep.…”

Section: Further Discussion and Conclusionmentioning

confidence: 99%

A review on prolificacy genes in sheep

Abdoli

Zamani

Mirhoseini

et al. 2016

Reprod Domestic Animals

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Ovulation rate and litter size are important reproduction traits in sheep and are of high economic value. Reproduction traits typically have low to medium heritabilities and do not exhibit a noticeable response to phenotypic selection. Therefore, inclusion of genetic information of the genes associated with reproductive ability could efficiently enhance the selection response. The most important major genes affecting prolificacy and their genetic diversities in different sheep breeds were reviewed. Different causative mutations with major effects on reproductive traits including ovulation rate and litter size have been found in various sheep breeds around the world. A general overview of the studies on main prolificacy genes showed that some alleles may express different phenotypic effects in different breeds, and thus, further studies on epistatic effects are necessary for more understanding of genetic control of reproductivity in sheep. Regarding the polygenic control of fertility traits, application of new high-throughput technologies to find new variants is essential for future studies. Moreover, genomewide association studies and genomic best linear unbiased predictions of breeding values are likely to be effective tools for genetic improvement of sheep reproductive performance traits.

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Genomewide association study to detect QTL for twinning rate in Baluchi sheep

Cited by 25 publications

References 16 publications

Recent advances in understanding genetic variants associated with economically important traits in sheep (Ovis aries) revealed by high-throughput screening technologies

Recent advances in understanding genetic variants associated with economically important traits in sheep (Ovis aries) revealed by high-throughput screening technologies

Whole genome sequence analysis to detect signatures of positive selection for high fecundity in sheep

A review on prolificacy genes in sheep

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