Genomewide differential expression profiling of long non‐coding <scp>RNA</scp>s in androgenetic alopecia in a Chinese male population

Bao, Linlin; Yu, Aixi; Ying, Luo; Tian, Tian; Dong, Ying; Zong, Haifeng; Chen, Hong‐Duo; Gao, Xinghua; Xu, Xue‐Gang; Li, Yuanhong

doi:10.1111/jdv.14278

Cited by 17 publications

(16 citation statements)

References 29 publications

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“…[36][37][38][39] A Chinese study has suggested that AGA-associated long noncoding RNAs and their target genes may serve as promising therapeutic targets for preventing and treating AGA. 40 Further studies will be needed to confirm the efficacy and safety of these treatments.…”

Section: Discussionmentioning

confidence: 99%

Early-onset androgenetic alopecia in China: a descriptive study of a large outpatient cohort

Ding

Sun

et al. 2020

J Int Med Res

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Objective: To describe the clinical features of early-onset androgenetic alopecia (AGA) in a large cohort of Chinese patients. Methods: This descriptive study recruited consecutive patients seeking medical treatment for AGA between 1 January 2013 and 30 November 2018. Patients were included in the study if they reported being 35 years old at AGA onset and if their pattern of hair loss was documented with photographs. The age of onset, sex, body mass index (BMI), BAsic and SPecific classification of hair loss and family history of alopecia were collected in an electronic database. Results: A total of 3897 patients with early-onset AGA were recruited to the study. The majority of patients (70.6%; 2751 of 3897) were 21-30 years old and male (72.7%; 2834 of 3897). No association was found between high BMI (!25 kg/m 2) and early-onset AGA. There were significantly more overweight male AGA patients than overweight female patients (86.8% [632 of 728] versus 13.2% [96 of 728], respectively). The overall prevalence of familial AGA was 72.8% (2837 of 3897) and the condition was inherited more often from the father (52.8%; 1498 of 2837) than from the mother (24.3%; 688 of 2837). Conclusions: Early-onset AGA primarily affects male patients between 21-30 years of age. Males with early-onset AGA are likely to have inherited AGA from their fathers.

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Section: Discussionmentioning

confidence: 99%

Early-onset androgenetic alopecia in China: a descriptive study of a large outpatient cohort

Ding

Sun

et al. 2020

J Int Med Res

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“…Many studies have shown that inflammatory immune cells, such as CD4 + and CD8 + T cells, lead to dystrophic hair follicle cycling with premature entry into the telogen phase in alopecia areata-affected mice or human models ( Strazzulla et al, 2018 ). There is no existing evidence to show that inhibiting inflammation can treat androgenic alopecia, although more inflammatory molecules were found in skin regions affected by androgenic alopecia areas than the unaffected areas ( Bao et al, 2017 ). However, previous WIHN studies have shown that inflammation-related factors are capable of promoting de novo hair follicle growth ( Gay et al, 2013 ; Nelson et al, 2015 ; Wang et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

IL-36α Promoted Wound Induced Hair Follicle Neogenesis via Hair Follicle Stem/Progenitor Cell Proliferation

Gong

Xiao

et al. 2020

Front. Cell Dev. Biol.

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Background Wound-induced hair follicle neogenesis (WIHN) is a phenomenon of hair neogenesis that occurs at the center of a scar when the wound area is sufficiently large. Neogenic hair follicles are separated from the pre-existing follicles at the wound edge by a hairless circular region. This WIHN study provides a unique model for developing treatments for hair loss and deciphering the mechanisms underlying organogenesis in adult mammals. Methods The skin of a mouse was wounded by excising a 1.5 × 1.5 cm 2 square of full-thickness dorsal skin. iTRAQ technology was used to screen proteins differentially expressed between the inner and outer scar areas in a mouse model of WIHN, on post-wounding day 15, to identify the regulators of WIHN. Owing to the overexpression of interleukin-36α (IL-36α) in the de novo hair follicle growth area, the regulating effect of IL-36α overexpression in WIHN was investigated. Hair follicle stem/progenitor cells were counted by flow cytometry while the expression of hair follicle stem/progenitor cell markers ( Lgr5, Lgr6, Lrig1, K15 , and CD34 ) and that of Wnt/β-catenin and IL-6/STAT3 pathway intermediaries was detected by qPCR and western blotting. Results We found that wounding induced IL-36α expression. Incorporation of recombinant murine IL-36α (mrIL-36α) into murine skin wounds resulted in a greater number of regenerated hair follicles ( p < 0.005) and a faster healing rate. The expression of hair follicle stem/progenitor cell markers was upregulated in the mrIL-36α-injected site ( p < 0.05). Additionally, mrIL-36α upregulated the IL-6/STAT3 pathway intermediaries. Conclusion IL-36α is upregulated in de novo hair follicle growth areas and can promote wound epithelialization and WIHN.

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“…Also, for the biology of hair follicle, specific lncRNAs, such as ANCR, TINCR, HOTAIR, SPRY4-IT1 have been identified to be involved in the regulation of the HF cycle (Wan and Wang, 2014). Bao et al (2017) reported a total of 2143 lncRNAs to be differentially expressed (fold change > 2.4) between AGA and adjacent normal tissues in a Chinese male population. Our previous study analyzed the differential expression pattern in passage-4 vs. passage-10 DP cells in a lncRNA microarray.…”

Section: Introductionmentioning

confidence: 99%

LncRNA H19 Overexpression Activates Wnt Signaling to Maintain the Hair Follicle Regeneration Potential of Dermal Papilla Cells

et al. 2020

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Androgenetic alopecia (AGA) is a common hair loss disorder resulting in seriously abnormal social interaction and psychological disorders. Transplantation with autologous dermal papilla cells represents a prospective therapy. However, the ability of dermal papilla cells to induce hair follicle development is lost upon cell culturing. Long non-coding RNAs (lncRNAs) are an important class of genes involved in various biological functions, are aberrantly expressed in disease and may play roles in the regulation of Wnt signaling, a critical pathway in maintaining the hair follicle-inducing capability of dermal papilla cells. Examination of dermal papilla cells by lncRNA microarray revealed that H19 was highly expressed in early passage dermal papilla cells compared with late-passage dermal papilla cells. In this study, we constructed H19-overexpressing dermal papilla cells to examine the role of H19 on hair follicle inductivity. Dermal papilla cells infected with lentivirus encoding H19 maintained their cell shape, and continued to display both multiple-layer aggregation and hair follicleinducing ability upon prolonged culture. H19 exerted these effects through inducing miR-29a to activate Wnt signaling by directly downregulating the expression of Wnt suppressors, including DKK1, Kremen2, and sFRP2, thereby forming a novel regulatory feedback loop between H19 and miR-29a to maintain hair follicle-inducing potential. These results suggest that lncRNA H19 maintains the hair follicle-inducing ability of dermal papilla cells through activation of the Wnt pathway and could be a target for treatment of androgenetic alopecia.

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Genomewide differential expression profiling of long non‐coding RNAs in androgenetic alopecia in a Chinese male population

Abstract: To our knowledge, this is the first study to investigate AGA-associated lncRNAs. lncRNA profiles are altered in AGA, and these lncRNAs and their target genes may serve as novel candidates for preventing and treating AGA.

Cited by 17 publications

References 29 publications

Early-onset androgenetic alopecia in China: a descriptive study of a large outpatient cohort

Early-onset androgenetic alopecia in China: a descriptive study of a large outpatient cohort

IL-36α Promoted Wound Induced Hair Follicle Neogenesis via Hair Follicle Stem/Progenitor Cell Proliferation

LncRNA H19 Overexpression Activates Wnt Signaling to Maintain the Hair Follicle Regeneration Potential of Dermal Papilla Cells

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