Genomic and Functional Regulation of TRIB1 Contributes to Prostate Cancer Pathogenesis

Shahrouzi, Parastoo; Astobiza, Ianire; Cortazar, Ana R.; Torrano, Verónica; Macchia, Alice; Flores, Juana M.; Niespolo, Chiara; Mendizabal, Isabel; Caloto, Rubén; Ercilla, Amaia; Camacho, Laura; Arreal, Leire; Bizkarguenaga, Maider; Martínez‐Chantar, María Luz; Bustelo, Xosé R.; Berra, Edurne; Kiss-Tóth, Endre; Velasco, Guillermo; Zabala-Letona, Amaia; Carracedo, Arkaitz

doi:10.3390/cancers12092593

Cited by 17 publications

(11 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, TRIB1 also accelerates degradation of C/EBPα in AML cells [ 98 ]. In addition, TRIB1 is also involved in the etiology of glioma [ 99 ], liver [ 100 ] and prostate cancer [ 101 ]. Regarding TRIB3, its expression was found elevated in patients with colorectal cancer and its expression correlated with poor overall survival [ 102 ].…”

Section: The Emerging Role Of Trib2 In Therapy Resistancementioning

confidence: 99%

The Critical Role of TRIB2 in Cancer and Therapy Resistance

Mayoral-Varo

Jiménez

Link

2021

Cancers

View full text Add to dashboard Cite

The Tribbles pseudokinases family consists of TRIB1, TRIB2, TRIB3 and STK40 and, although evolutionarily conserved, they have distinctive characteristics. Tribbles members are expressed in a context and cell compartment-dependent manner. For example, TRIB1 and TRIB2 have potent oncogenic activities in vertebrate cells. Since the identification of Tribbles proteins as modulators of multiple signalling pathways, recent studies have linked their expression with several pathologies, including cancer. Tribbles proteins act as protein adaptors involved in the ubiquitin-proteasome degradation system, as they bridge the gap between substrates and E3 ligases. Between TRIB family members, TRIB2 is the most ancestral member of the family. TRIB2 is involved in protein homeostasis regulation of C/EBPα, β-catenin and TCF4. On the other hand, TRIB2 interacts with MAPKK, AKT and NFkB proteins, involved in cell survival, proliferation and immune response. Here, we review the characteristic features of TRIB2 structure and signalling and its role in many cancer subtypes with an emphasis on TRIB2 function in therapy resistance in melanoma, leukemia and glioblastoma. The strong evidence between TRIB2 expression and chemoresistance provides an attractive opportunity for targeting TRIB2.

show abstract

Section: The Emerging Role Of Trib2 In Therapy Resistancementioning

confidence: 99%

The Critical Role of TRIB2 in Cancer and Therapy Resistance

Mayoral-Varo

Jiménez

Link

2021

Cancers

View full text Add to dashboard Cite

show abstract

“…Shahrouzi et al found that the expression of TRIB1 in the prostate of mice with PCa ( Pten pc-/- ) was higher than in wild-type controls ( Pten pc+/+ ). They then developed a Cre-dependent TRIB1 transgenic mouse model, in which the incidence of PCa was increased in Pten pc+/- mice from 16.7% to 50% 41 . Additionally, TRIB1 participates in the endoplasmic reticulum pathway and is required for the expression of the endoplasmic reticulum partner GRP78, which is closely related to the occurrence of prostate tumors 36 .…”

Section: Trib1 and Cancermentioning

confidence: 99%

Current Progress in Delineating the Roles of Pseudokinase TRIB1 in Controlling Human Diseases

Zhang

et al. 2021

J. Cancer

View full text Add to dashboard Cite

Tribbles homolog 1 (TRIB1) is a member of the tribbles family of pseudoprotein kinases and is widely expressed in numerous tissues, such as bone marrow, skeletal muscle, liver, heart, and adipose tissue. It is closely associated with acute myeloid leukemia, prostate cancer, and tumor drug resistance, and can interfere with the hematopoietic stem cell cycle, promote tumor cell proliferation, and inhibit apoptosis. Recent studies have shown that TRIB1 can regulate acute and chronic inflammation by affecting the secretion of inflammatory factors, which is closely related to the occurrence of hyperlipidemia and cardiovascular diseases. Given the important biological functions of TRIB1, the reviews published till now are not sufficiently comprehensive. Therefore, this paper reviews the progress in TRIB1 research aimed at exploring its roles in cancer, hyperlipidemia, and cardiovascular disease, and providing a theoretical basis for further studies on the biological roles of TRIB1.

show abstract

“…Notably, TRIB1 protein levels are relatively high in the PC3 cell line, whereas COP1 is undetectable, raising the question whether COP1 under specific stimulatory conditions may mark TRIB1 for proteasome-mediated degradation. Increasing TRIB1 expression in these PC3 cells has been shown to promote tumour growth [ 58 ], whereas increasing TRIB1 in DU145 cells did not [ 59 ]. Consequently, we keenly await proteomic analyses of the TRIB-interactome in the COP1-less PC3 cells, as well as structural studies that define the effects of TRIB1-captured protein substrates on the release of its sequestered C-terminal COP1-binding motif.…”

Section: Growth Of Trib (And Cop1) Researchmentioning

confidence: 99%

“…Returning to the TRAIN tool-box, this includes a series of scripts to interrogate and visualise genomic data, plasmid and viral constructs, and murine models to study the physiological roles of cell-specific TRIB1 and TRIB3 expression, for example, in myeloid cells [ 70 ], prostate-specific Pten -deficient mice [ 59 ] and Tregs ( Trib1 KO , richard.danger@univ-nantes.fr ; sophie.brouard@univ-nantes.fr ). Finally, we would like to thank the wider TRIB community for their contribution to student TRAIN training events and bi-annual international TRIB conferences.…”

Section: Growth Of Trib (And Cop1) Researchmentioning

confidence: 99%

Musings from the Tribbles Research and Innovation Network

Ruiz-Cantos

Hutchison

Shoulders

2021

Cancers

View full text Add to dashboard Cite

This commentary integrates historical and modern findings that underpin our understanding of the cell-specific functions of the Tribbles (TRIB) proteins that bear on tumorigenesis. We touch on the initial discovery of roles played by mammalian TRIB proteins in a diverse range of cell-types and pathologies, for example, TRIB1 in regulatory T-cells, TRIB2 in acute myeloid leukaemia and TRIB3 in gliomas; the origins and diversity of TRIB1 transcripts; microRNA-mediated (miRNA) regulation of TRIB1 transcript decay and translation; the substantial conformational changes that ensue on binding of TRIB1 to the transcription factor C/EBPα; and the unique pocket formed by TRIB1 to sequester its C-terminal motif bearing a binding site for the E3 ubiquitin ligase COP1. Unashamedly, the narrative is relayed through the perspective of the Tribbles Research and Innovation Network, and its establishment, progress and future ambitions: the growth of TRIB and COP1 research to hasten discovery of their cell-specific contributions to health and obesity-related cancers.

show abstract

Genomic and Functional Regulation of TRIB1 Contributes to Prostate Cancer Pathogenesis

Cited by 17 publications

References 80 publications

The Critical Role of TRIB2 in Cancer and Therapy Resistance

The Critical Role of TRIB2 in Cancer and Therapy Resistance

Current Progress in Delineating the Roles of Pseudokinase TRIB1 in Controlling Human Diseases

Musings from the Tribbles Research and Innovation Network

Contact Info

Product

Resources

About