Genomic diversity and recombination of Seneca Valley viruses emerged in pig herds in Guangdong Province during 2019

Liu, Jianxin; Guo, Qianju; Li, Huizi; Yu, Xianglong; Liu, Boyang; Zhao, Bingqian; Ning, Zhangyong

doi:10.1007/s11262-020-01769-x

Cited by 7 publications

(8 citation statements)

References 15 publications

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“…CH-GDFS-2018 is a wild type virus isolated by our group in 2018 with recombinant features [ 39 ]. In order to verify whether the clinically isolated strains have the same characteristics that promote glycolysis, the mRNA levels of HIF-1α, PGK1, HK2, SOD2, PKM and PFKM after cell infected with CH-GDQC-2017 [ 40 ] and CH-GDZS-2019 [ 41 ] were quantified, and the results showed that these strains had similar abilities to cause glycolysis ( S2 Fig ), indicating that glycolysis induced by SVA infection is not unique to a particular strain. Glycolysis is closely related to immunity, and most cancer cells favor glycolysis for energy metabolism, known as the Warburg effect, as well as high lactate production, to enhance their survival and proliferation [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Senecavirus A-induced glycolysis facilitates virus replication by promoting lactate production that attenuates the interaction between MAVS and RIG-I

Lin

et al. 2023

PLoS Pathog

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Senecavirus A (SVA)-induced porcine idiopathic vesicular disease has caused huge economic losses worldwide. Glucose metabolism in the host cell is essential for SVA proliferation; however, the impact of the virus on glucose metabolism in host cells and the subsequent effects are still unknown. Here, glycolysis induced by SVA is shown to facilitate virus replication by promoting lactate production, which then attenuates the interaction between the mitochondrial antiviral-signaling protein (MAVS) and retinoic acid-inducible gene I (RIG-I). SVA induces glycolysis in PK-15 cells, as indicated by significantly increased expression of hexokinase 2 (HK2), 6-phosphofructokinase (PFKM), pyruvate kinase M (PKM), phosphoglycerate kinase 1 (PGK1), hypoxia-inducible factor-1 alpha (HIF-1α), and superoxide dismutase-2 (SOD2) in a dose-and replication-dependent manner, and enhanced lactate production, while reducing ATP generation. Overexpression of PKM, PGK1, HIF-1α, and PDK3 in PK-15 cells and high glucose concentrations promote SVA replication, while glycolytic inhibitors decrease it. Inhibition of RLR signaling allowed better replication of SVA by promoting lactate production to attenuate the interaction between MAVS and RIG-I, and regulatory effect of glycolysis on replication of SVA was mainly via RIG-I signaling. SVA infection in mice increased expression of PKM and PGK1 in tissues and serum yields of lactate. Mice treated with high glucose and administered sodium lactate showed elevated lactate levels and better SVA replication, as well as suppressed induction of RIG-I, interferon beta (IFNβ), IFNα, interferon-stimulated gene 15 (ISG15), and interleukin 6 (IL-6). The inhibitory effect on interferons was lower in mice administered sodium oxamate and low glucose compared to the high glucose, indicating that RLR signaling was inhibited by SVA infection through lactate in vitro and in vivo. These results provide a new perspective on the relationship between metabolism and innate immunity of the host in SVA infection, suggesting that glycolysis or lactate may be new targets against the virus.

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Section: Discussionmentioning

confidence: 99%

Senecavirus A-induced glycolysis facilitates virus replication by promoting lactate production that attenuates the interaction between MAVS and RIG-I

Lin

et al. 2023

PLoS Pathog

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“…Comparatively speaking, recombination appears to occur at a high frequency in picornaviruses ( 29 ) and readily occurs between closely related strains (intratypic recombination) in picornaviruses ( 30 ). Previous studies successfully identified one and eight recombinants isolated from Canada ( 31 ) and China ( 32 – 35 ), respectively. Unlike previous reports, our rigorous analysis only identified five recombinants, all of which were isolated from China.…”

Section: Discussionmentioning

confidence: 99%

The Evolution and Global Spatiotemporal Dynamics of Senecavirus A

et al. 2022

Microbiol Spectr

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“…The intra-species recombination is an unpredictable event ( 30 ). Liu et al ( 29 ) showed that two China variants (CH-GDZS-2019 and CH-GDMZ-2019), albeit isolated from the same province in 2019, had different results of recombination analysis. The CH-GDZS-2019 was genetically derived from USA-IA44662–2015-P1 and USA-GBI29-2015, both of which were isolated from the USA in 2015, while the CH-GDMZ-2019 was genetically derived from two China isolates ( 29 ).…”

Section: Sva Intra-species Recombinationmentioning

confidence: 99%

RNA recombination: non-negligible factor for preventing emergence or reemergence of Senecavirus A

Li,

Liu,

Zhang

et al. 2024

Front. Vet. Sci.

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Genomic diversity and recombination of Seneca Valley viruses emerged in pig herds in Guangdong Province during 2019

Cited by 7 publications

References 15 publications

Senecavirus A-induced glycolysis facilitates virus replication by promoting lactate production that attenuates the interaction between MAVS and RIG-I

Senecavirus A-induced glycolysis facilitates virus replication by promoting lactate production that attenuates the interaction between MAVS and RIG-I

The Evolution and Global Spatiotemporal Dynamics of Senecavirus A

RNA recombination: non-negligible factor for preventing emergence or reemergence of Senecavirus A

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