Genomic Identity of Fluoroquinolone-Resistant blaCTX-M-15-Type ESBL and pMAmpC β-Lactamase Producing Klebsiella pneumoniae from Buffalo Milk, India

Bandyopadhyay, Samiran; Banerjee, Jaydeep; Bhattacharyya, Debasish; Samanta, Indranil; Mahanti, Achintya; Dutta, Tapan Kumar; Ghosh, S. K.; Nanda, Pramod Kumar; Bandyopadhyay, S.

doi:10.1089/mdr.2017.0368

Cited by 24 publications

(19 citation statements)

References 45 publications

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“…Abundance of PMQR genes documented in this study is in corroboration with our previous observations with the ESBLproducing Enterobacteriaceae from bovine and bubaline milk. 24,49,50 The drug efflux pump-qepA was detected in three isolates; all of which exhibited considerably higher MIC to nalidixic acid (results not shown). The gene qepA is an antiporter quinolone EP system having considerable similarity to the MFS-type efflux pumps, which actively excrete the drugs from the cytosol to the exterior of bacterial cells.…”

Section: Discussionmentioning

confidence: 94%

“…About 22.8% of the diarrheic animals (50/219) carried ESBLPs in contrast to 15.6% of the HC (5/32); this is quite higher than what we observed in cow and buffalo milk in our previous studies. 24,49,50 The occurrence of ESBL-producing E. coli in healthy or diarrheic cattle varies widely (3-63%) in different geographical locations with diverse antibiotic exposure, husbandry practices, and isolation techniques. [51][52][53] Most of the ESBL (+ve) isolates from bovine diarrhea cases exhibited resistance to nalidixic acid/enrofloxacin, tetracycline (100% each), gentamicin (76%), and imipenem (80%) with MARI ranging from 0.6 to 1.0.…”

Section: Discussionmentioning

confidence: 99%

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Characterization of Multidrug-Resistant Biofilm-Producing Escherichia coli and Klebsiella pneumoniae in Healthy Cattle and Cattle with Diarrhea

Bandyopadhyay

Bhattacharyya

Samanta

et al. 2021

Microbial Drug Resistance

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Characterization of Multidrug-Resistant Biofilm-Producing Escherichia coli and Klebsiella pneumoniae in Healthy Cattle and Cattle with Diarrhea

Bandyopadhyay

Bhattacharyya

Samanta

et al. 2021

Microbial Drug Resistance

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“…Further, Koovapra et al [ 75 ] reported ESBL producing K. pneumonia in bovine milk collected from three states of eastern and north-eastern India. More recently, ESBL producing K. pneumonia was isolated from buffalo milk and characterized [ 76 ]. All these studies pointed out that most of the ESBL producers from bovine milk also harboured AmpC type b-lactamase and plasmid mediated fluoroquinolone resistance gene(s).…”

Section: Resultsmentioning

confidence: 99%

A review of animal health and drug use practices in India, and their possible link to antimicrobial resistance

Mutua

Sharma

Grace

et al. 2020

Antimicrob Resist Infect Control

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Background: Livestock production, particularly the dairy sector, is important for food and nutritional wellbeing of communities in India, it supports livelihoods of many farmers, and contributes to the economy of the country. India is a high consumer of antibiotics and antimicrobial resistant (AMR) bacteria are a major public health concern. Objectives: Our objectives were to identify animal health and drug use practices that may contribute to emergence and spread of AMR in the country, review previous AMR-mitigation strategies, and discuss "theory of change" as an approach to informing the choice of interventions. Methods: We undertook a desk review of literature to identify practices with potential to contribute to emergence and spread of antimicrobial resistance in India. Searches were done in PubMed, Google scholar, and Google. Data were synthesized and discussed by themes. Results: Animal disease surveillance is less developed and infrastructure to support delivery of services is inadequate. Several groups are known to offer animal health services. The untrained "animal health workers" and para-veterinarians are more popular with farmers as they charge less for consultations (compared to veterinarians who are few and charge more). Over-the-counter access of antibiotics, without prescription, and direct marketing of drugs to farmers are common. Because of this, farmers are able to treat their animals and only consult when cases become non-responsive to treatment. Antibiotics are mostly used in management of mastitis cases. Drug withdrawal periods are rarely observed and occurrence of antibiotic-contaminated milk has been reported. Awareness on AMR is low and antimicrobial stewardship in livestock is yet to be developed. Initiatives such as the National programme for containment of AMR, National Action Plan on AMR, and the National Health policy point to government's commitment in addressing the problem of AMR in the country. Conclusion: Several animal health and drug use practices, with potential to cause AMR, have been described, and their contribution can be discussed further by engaging stakeholders in a "theory of change" exercise. Interventions that address AMR from the animal health perspective should be promoted, and incentives to increase their adoption explored.

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“…Among other common types of the ESBLs in bovines from various LMICs were SHV-180, OXA-10, SHV-5 (Turkey), SHV-12 (Turkey and Egypt), SHV-180 (India), OXA-30 (Egypt), and TEM (India) (78). A number of studies conducted by our group revealed the presence of some ESBL variants in bovine mastitis wherein we could not trace any known ESBL genes by PCR screeningexistence of a novel ESBL mechanism in this part cannot be ruled out (79,80). Cattle manure is widely used as biological fertilizer, which increases the chance of environmental dissemination of ESBLs from a fecal source.…”

Section: Cephalosporin Resistant Bacteriamentioning

confidence: 72%

Antimicrobial Resistance in Agri-Food Chain and Companion Animals as a Re-emerging Menace in Post-COVID Epoch: Low-and Middle-Income Countries Perspective and Mitigation Strategies

Bandyopadhyay

Samanta

2020

Front. Vet. Sci.

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Antimicrobial resistance (AMR) leads to enormous financial losses from issues such as high morbidity, mortality, man-days lost, hospital length of stay, health-care, and social costs. In humans, over prescription of antimicrobials, which is presumably higher during COVID, has been identified as the major source of selection for antimicrobial resistant bacteria; however, use of antimicrobials in food and companion animals, fish, and vegetables, and the environmental resistance gene pool, also play important roles. The possibilities of unnecessary use of antibiotics as prophylaxis during and after COVID in livestock and companion animals exist in low-and middle-income countries. A considerable loss in gross domestic product (GDP) is also projected in low-and middle-income countries (LMICs) due to AMR by the year 2050, which is further going to be reduced due to economic slowdown in the post-COVID period. Veterinary hospitals dedicated to pets have cropped up, especially in urban areas of LMICs where use of antimicrobials has also been increased substantially. The inevitable preventive habit built up during COVID with the frequent use of hand sanitizer might trigger AMR due to the presence of cross-resistance with disinfectants. In LMICs, due to the rising demand for animal protein, industrial food animal production (IFAP) is slowly replacing the small-scale backyard farming system. The lack of stringent regulations and monitoring increased the non-therapeutic use of antimicrobials in industrial farms where the persistence of antimicrobial resistant bacteria has been associated with several factors other than antimicrobial use, such as co-resistance, cross-resistance, bacterial fitness, mixing of new and old animals, and vectors or reservoirs of bacterial infection. The present review describes types of antimicrobials used in agri-food chains and companion animals in LMICs with identification of the gap in data, updated categories of prevalent antimicrobial resistant bacteria, the role of animal farms as reservoirs of resistant bacteria, and mitigation strategies, with a special focus on the pivotal strategy needed in the post-COVID period.

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Genomic Identity of Fluoroquinolone-Resistant blaCTX-M-15-Type ESBL and pMAmpC β-Lactamase Producing Klebsiella pneumoniae from Buffalo Milk, India

Cited by 24 publications

References 45 publications

Characterization of Multidrug-Resistant Biofilm-Producing Escherichia coli and Klebsiella pneumoniae in Healthy Cattle and Cattle with Diarrhea

Characterization of Multidrug-Resistant Biofilm-Producing Escherichia coli and Klebsiella pneumoniae in Healthy Cattle and Cattle with Diarrhea

A review of animal health and drug use practices in India, and their possible link to antimicrobial resistance

Antimicrobial Resistance in Agri-Food Chain and Companion Animals as a Re-emerging Menace in Post-COVID Epoch: Low-and Middle-Income Countries Perspective and Mitigation Strategies

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