Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue

Schäffler, Andréas; Neumeier, Markus; Herfarth, Hans H; Fürst, Alois; Schölmerich, Jürgen; Büchler, Christa

doi:10.1016/j.bbaexp.2005.11.005

Cited by 310 publications

(250 citation statements)

References 13 publications

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“…23 It is strongly expressed in the human ovaries and placenta. 92,8 It is a secreted protein, with the most profound level of expression in the stromal cells, rather than the adipocytes, of omental adipose tissue. 23 Recombinant omentin enhances the uptake of glucose in isolated adipocytes and dramatically increases the insulin induction of Akt/PKB phosphorylation.…”

Section: Does Adiponectin Play An Essential Role In Ovarian/ Uterine/mentioning

confidence: 99%

The ‘beneficial’ adipokines in reproduction and fertility

et al. 2007

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The objective of this study was to review the available information on the signaling proteins produced by adipose tissue in the context of their role in regulating reproductive processes, including ovarian and uterine function. It is well known that both obesity and excessive leanness are associated with reproductive dysfunction. Adipokines are cytokines predominately or exclusively expressed by adipose tissue that circulate and affect target tissues. Four known adipokines, adiponectin, visfatin/ PBEF, omentin and vaspin, all increase tissue sensitivity to insulin, and are thus described as 'beneficial'. There is strong support for a role for adiponectin in the function of the ovary and placenta. There is evidence for direct effects of this adipokine on the late stages of folliculogenesis, and additive interactions of adiponectin with insulin and gonadotropins in inducing periovulatory changes in ovarian follicles. In addition, clinical and genomic studies associate hypoadiponectinemia with obesity-related reproductive disorders, including the polycystic ovarian syndrome. The roles for visfatin/PBEF, omentin and vaspin in reproduction remain to be established. The conclusion thus drawn is that the expression of insulin-sensitizing adipokines varies with adipose abundance. These adipokines have demonstrated both the potential effects on ovarian function and the possible effects on the formation of the placenta, acting through multiple mechanisms.

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Section: Does Adiponectin Play An Essential Role In Ovarian/ Uterine/mentioning

confidence: 99%

The ‘beneficial’ adipokines in reproduction and fertility

et al. 2007

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“…Omentin-1 is a novel 34 kDa adipocytokine, which in comparison with subcutaneous adipose tissue, is highly and selectively expressed in visceral adipose tissue [12,13]. Furthermore, omentin-1 enhances insulin action and Akt phosphorylation [14]; it is inversely related to obesity [15] and is down regulated by insulin and glucose [13].…”

Section: Introductionmentioning

confidence: 99%

Omentin-1, visfatin and adiponectin levels in relation to bone mineral density in Iranian postmenopausal women

Tohidi

Akbarzadeh

Larijani

et al. 2012

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The bone and fat interface is implicated in the pathogenesis of postmenopausal osteoporosis. The association between circulating omentin-1 levels and bone mineral density (BMD) in postmenopausal women has never been assessed. A total of 382 healthy postmenopausal women were randomly selected. Omentin-1, visfatin, adiponectin, the receptor activator of nuclear factor-κB ligand (RANKL), osteoprotegerin, high sensitivity C-reactive protein, degradation products of C-terminal telopeptides of type I collagen, and osteocalcin were measured by highly specific enzyme-linked immunosorbent assay methods. BMD was determined for the lumbar spine (L2-L4) and the proximal femur using dual-energy X-ray absorptiometry. In multivariable-adjusted linear regression, serum omentin-1 levels were inversely correlated with BMD at the lumbar spine (β =−0.11, p= 0.020). In multiple regression analyses, serum visfatin and adiponectin levels were not significantly correlated with BMD at different skeletal sites after controlling for age, body mass index, and bone-related markers. However, the highest quartile of adiponectin compared to the lowest quartile, after adjusting for potential confounders, revealed an inverse association with BMD in the lumbar spine (β=−0.19, p=0.010). In conclusion, circulating omentin-1 levels had an inverse correlation with BMD at the lumbar spine in Iranian postmenopausal women. To further understand the role of omentin-1 in bone and mineral metabolism, large-scale longitudinal studies focusing on BMD and osteoporotic fractures are warranted.

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“…[1][2][3] Omentin, also known as intelectin-1, is a recently identified adipocytokine, whose expression is abundantly detected in human visceral fat tissue. [4][5][6] Omentin is detectable in human plasma and is downregulated in subjects with obesity and type 2 diabetes. 7,8 Low levels of plasma omentin are also associated with insulin resistance and endothelial dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Association of a fat-derived plasma protein omentin with carotid artery intima-media thickness in apparently healthy men

et al. 2011

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Obesity is causally linked with the development of atherosclerosis. Omentin is an adipocytokine whose concentrations are reduced in obese individuals. Here we examined the relationship between plasma omentin levels and carotid intima-media thickness (IMT), a marker of early atherosclerosis, in apparently healthy Japanese men. Participants were 100 Japanese men who underwent a medical checkup. Maximal IMT (max-IMT) and mean-IMT in common carotid artery were measured by highresolution carotid ultrasound system. Plasma omentin concentrations were determined by enzyme-linked immunosorbent assay. Circulating omentin levels correlated negatively with body mass index, waist circumference, fasting glucose, creatinine, max-IMT and mean-IMT, and positively with estimated glomerular filtration rates (eGFR). Single regression analysis demonstrated that max-IMT associated with age, eGFR and omentin levels, and that mean-IMT associated with age, fasting glucose, eGFR and omentin levels. Multiple regression analysis revealed that omentin levels, together with age, correlated with max-IMT and mean-IMT. Our data document that circulating omentin levels independently and negatively associate with carotid IMT in this population, suggesting that measurement of omentin may be useful for assessment of carotid IMT.

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Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue

Cited by 310 publications

References 13 publications

The ‘beneficial’ adipokines in reproduction and fertility

The ‘beneficial’ adipokines in reproduction and fertility

Omentin-1, visfatin and adiponectin levels in relation to bone mineral density in Iranian postmenopausal women

Association of a fat-derived plasma protein omentin with carotid artery intima-media thickness in apparently healthy men

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