Genomics and precision surgery for head and neck squamous cell carcinoma

Galmiche, Antoine; Saidak, Zuzana; Bouaoud, Jebrane; Mirghani, Haïtham; Page, C.; Dakpe, Stéphanie; Clatot, Florian

doi:10.1016/j.canlet.2020.04.004

Cited by 10 publications

(24 citation statements)

References 129 publications

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“…This initial step of surgical practice does not take into account tumor biology (i.e., pattern of growth, inflammation, grading). 54 Using data from TCGA, we reported a three-gene expression signature unrelated to the TNM but associated with the presence of positive SMs in resected tongue tumors. 55 Use of this signature to examine a set of tumors microscopically showed an invasive growth pattern characterized by the presence of immature cancer cells growing as trabeculae, a pattern that might have been missed by initial tumor imaging.…”

Section: Staging Of Oscc Before Surgerymentioning

confidence: 99%

“… 55 Although it is unclear at this stage whether tumor biology also is important for other sites of the oral cavity, we suggest that genomics might potentially be useful in determining the nature and extent of the surgical procedure for locally advanced OSCC. 54 For example, analyzing the propensity of OSCC to invade bone tissue could be useful in determining the extent of mandible resection in case of bone extension. 54 …”

Section: Staging Of Oscc Before Surgerymentioning

confidence: 99%

“… 54 For example, analyzing the propensity of OSCC to invade bone tissue could be useful in determining the extent of mandible resection in case of bone extension. 54 …”

Section: Staging Of Oscc Before Surgerymentioning

confidence: 99%

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Contribution of Genomics to the Surgical Management and Study of Oral Cancer

Saidak¹,

Lailler²,

Testelin³

et al. 2021

Ann Surg Oncol

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Background Oral squamous cell carcinoma (OSCC) is the most frequent type of tumor arising from the oral cavity. Surgery is the cornerstone of the treatment of these cancers. Tumor biology has long been overlooked as an important contributor to the outcome of surgical procedures, but recent studies are challenging this concept. Molecular analyses of tumor DNA or RNA provide a rich source of information about the biology of OSCC. Methods We searched for relevant articles using PubMed. We examined in particular the prospect of applying molecular methods for minimally invasive exploration of OSCC biology. Results We examined five potential applications of genomics to the surgical management and study of OSCC: i) assessing oral potentially malignant lesions; ii) tumor staging prior to surgery; iii) predicting postoperative risk in locally advanced tumors; iv) measuring minimal residual disease and optimizing the longitudinal monitoring of OSCC; and v) predicting the efficacy of medical treatment. Conclusions Genomic information can be harnessed in order to identify new biomarkers that could improve the staging, choice of therapy and management of OSCC. The identification of new biomarkers is awaited for better personalization of the surgical treatment of OSCC.

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Section: Staging Of Oscc Before Surgerymentioning

confidence: 99%

Section: Staging Of Oscc Before Surgerymentioning

confidence: 99%

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Contribution of Genomics to the Surgical Management and Study of Oral Cancer

Saidak¹,

Lailler²,

Testelin³

et al. 2021

Ann Surg Oncol

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“…Precision medicine, i.e., individually-adapted therapy, guided by biomarkers reflecting tumor biology, is familiar to medical oncologists. An equivalent concept of precision surgery has not yet come to everyday clinical practice [ 10 ]. Galmiche et al argue that tumor biology is likely critical in post-surgical recurrence and, conversely, that surgical/anesthetic procedures might modulate specific aspects of tumor biology during the perioperative period.…”

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confidence: 99%

Editorial: Oral Oncology: From Precise Surgery to Precision Medicine and Surgery

Saidak

Piazza

2022

Front. Oral. Health

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“…L'émergence d'atlas comme le TCGA (The Cancer Genome Atlas) permet aujourd'hui un accès libre aux données de génomique et de protéomique, et donc d'envisager une nouvelle taxonomie moléculaire des tumeurs [4,5]. Grâce aux développements des techniques fondées sur l'analyse des acides nucléiques libérés par les cellules tumorales, il devient également envisageable de « sonder » de façon non invasive, par biopsies liquides, le génome tumoral, en particulier en amont de la procédure chirurgicale [6,7]. La montée en puissance des traitements ciblés a par ailleurs constitué une avancée conceptuelle majeure.…”

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Principe et applicabilité de la chirurgie de précision aux cancers de la tête et du cou

et al. 2022

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La chirurgie est la modalité de traitement curatif la plus fréquemment utilisée dans les cancers de la tête et du cou. Elle est intégrée dans des schémas de stratification thérapeutique précis, mais la conduite de l’acte chirurgical et son évaluation ne tiennent, la plupart du temps, pas compte de la biologie tumorale. Nous présentons dans cette revue plusieurs études qui montrent comment les analyses de la biologie tumorale pourraient préciser les indications et le contour d’une résection chirurgicale, personnaliser la prise en charge péri-opératoire du patient, et faciliter la détection des récurrences tumorales. Ces études apportent ainsi une preuve de principe qu’une chirurgie de précision, c’est-à-dire adossée à la biologie tumorale, à la façon de la médecine de précision pour d’autres cancers, est applicable aux cancers de la tête et du cou.

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Genomics and precision surgery for head and neck squamous cell carcinoma

Cited by 10 publications

References 129 publications

Contribution of Genomics to the Surgical Management and Study of Oral Cancer

Contribution of Genomics to the Surgical Management and Study of Oral Cancer

Editorial: Oral Oncology: From Precise Surgery to Precision Medicine and Surgery

Principe et applicabilité de la chirurgie de précision aux cancers de la tête et du cou

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