Genophenotypic Analysis of Angiotensinogen Gene M235T Polymorphism and Preeclampsia

Радьков, О. В.; Kalinkin, M N; Zavarin, V.

doi:10.1007/s10517-013-1949-z

Cited by 5 publications

(1 citation statement)

References 11 publications

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“…The development of preeclampsia in TT genotype carriers was associated with maximum activity of plasma renin. Heterozygous genotype of the AGT gene M235T polymorphism in pregnant women with hypertension was associated with a 1.13-fold decrease in renin activity, and MM genotype with a 1.7fold decrease (P=0.019) as compared to the TT genotype, these findings are agreed with study done by Radkov et al 2013. This specific feature distinguishes preeclampsia from arterial hypertension in non-pregnant individuals, when TT genotype is associated with maximum angiotensinogen concentration and minimum plasma renin activity (Radkov et al 2013).…”

Section: Resultssupporting

confidence: 81%

Association of Angiotensinogen M235T Gene variants, and Plasma Renin Activity with Preeclampsia

Elfadil

Alla²,

Elmugadam

2014

Egyptian Academic Journal of Biological Sciences. C, Physiology

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Preeclampsia is considered to be a multifactorial and multisystemic disorder with a genetic predisposition. Alterations in the reninangiotensin system are considered to play a significant role in the pathogenesis of the disease. In order to investigate the possible association of the most common polymorphisms of the reninangiotensin system genes with preeclampsia we have examined 50 women with preeclampsia and 50 normotensive pregnant women. DNA samples were genotyped for the M235T polymorphism of the angiotensinogen gene (AGT), plasma renin was determined by enzyme linked immunosorbent assay (ELISA). Plasma renin was significantly decreased in patients with preeclampsia compared with normotensive pregnant women. The TT genotype of the M235T polymorphism was significantly increased in women who developed preeclampsia. In preeclampsia group the frequency of AGT gene, M235T misssense mutation was 92% (18% were heterozygous and 82%were homozygous), compared with 56% in control group (34% heterozygous, 66% homozygous). In preeclampsia group the frequency of M allele; 17% (n=13) versus 61% (n=39) for the control group, while the frequency of T allele in preeclampsia group; 83% (n=47) versus 39% (n=28) for the control group. Furthermore, there was a positive risk of developing preeclampsia when having TT genotype, and the results were highly statistically significant (odd ratio=2.597, X 2 = 16.39, P =0.00) for TT genotype compared to MM genotype. There was significant positive correlation between plasma renin activity and mean arterial pressure (MAP) (r= 0.9, p= 0.000). There was no statistical significance between plasma renin activity and age in preeclampsia group (r= 0.044, p= 0.759). In conclusion, an increased risk for preeclampsia in women carrying the TT genotype of the AGT gene was observed. Plasma renin activity was significantly decreased in patients with preeclampsia.

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Section: Resultssupporting

confidence: 81%

Association of Angiotensinogen M235T Gene variants, and Plasma Renin Activity with Preeclampsia

Elfadil

Alla²,

Elmugadam

2014

Egyptian Academic Journal of Biological Sciences. C, Physiology

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Three polymorphisms of renin-angiotensin system and preeclampsia risk

Wang

Zhou

Liu

et al. 2020

J Assist Reprod Genet

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Purpose Some data suggest an association between the single nucleotide polymorphisms AGT T704C, ACE I/D, and AT1R A1166C and preeclampsia, but overall, the data are conflicting; the aim of our study was to discover a more stable and reliable association between these polymorphisms and PE risk. Methods A comprehensive literature search for this meta-analysis was conducted. Odds ratios (OR) and 95% confidence intervals (CIs) were calculated to evaluate the strength, and heterogeneity test was conducted. Trial sequential analysis was also performed. Results A total of forty studies were finally included in our meta-analysis. The AGT T704C polymorphism was associated with PE risk in three genetic models (dominant OR = 1.33, 95%CI = 1.12–1.59; heterozygote OR = 1.26, 95%CI = 1.05–1.52; homozygote OR = 1.44, 95%CI = 1.14–1.83). No heterogeneity was observed in the three genetic models for the ACE I/D polymorphism. For subgroup analysis by geography, no significant association was detected. Significant associations were observed in mixed race, early-onset, late-onset, and more than 200 subgroups for the AT1R A1166C polymorphism; however, only one study was analyzed in these subgroups. Conclusions Our results indicated the AGT T704C and ACE I/D polymorphisms were associated with an increased risk of PE. Increased risks were also observed for the two polymorphisms in subgroups including Asians, Europeans, Caucasoid, and Mongoloid. Moreover, an increased PE risk with the ACE I/D polymorphism in the severe PE population was also detected. Regarding the AT1R A1166C polymorphism, weak associations were observed, but further studies are required.

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Association of gene polymorphisms of four components of renin-angiotensin-aldosterone system and preeclampsia in South African black women

Aung

Konoshita

Moodley

et al. 2017

European Journal of Obstetrics & Gynecology and Reproductiv

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Genophenotypic Analysis of Angiotensinogen Gene M235T Polymorphism and Preeclampsia

Cited by 5 publications

References 11 publications

Association of Angiotensinogen M235T Gene variants, and Plasma Renin Activity with Preeclampsia

Association of Angiotensinogen M235T Gene variants, and Plasma Renin Activity with Preeclampsia

Three polymorphisms of renin-angiotensin system and preeclampsia risk

Association of gene polymorphisms of four components of renin-angiotensin-aldosterone system and preeclampsia in South African black women

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