Genoprotective effects of gallic acid against cisplatin induced genotoxicity in bone marrow cells of mice

Sd, Shruthi; Shenoy, K. Bhasker

doi:10.1039/c8tx00058a

Cited by 25 publications

(18 citation statements)

References 29 publications

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“…The flavonoids, catechins, and their derivatives have been considered as neuroprotective agents 16 . Our previous study confirmed the antimutagenic potential of GA against cisplatin induced genotoxicity in mice bone marrow cells 17 . Further our study gave some insight on immunostimulatory effect of GA against CP and cisplatin induced immunosuppression in Swiss albino mice 18 .…”

Section: Introductionsupporting

confidence: 69%

“…16 Our previous study confirmed the antimutagenic potential of GA against cisplatin induced genotoxicity in mice bone marrow cells. 17 Further our study gave some insight on immunostimulatory effect of GA against CP and cisplatin induced immunosuppression in Swiss albino mice. 18 These findings incited us to evaluate possible anticlastogenic, antigenotoxic, and antioxidant effects of GA against CP induced oxidative damage in Swiss albino mice.…”

mentioning

confidence: 76%

“…The visualized comets were classified under five categories or levels of damage: (0) no damage, (1) low damage, (2) moderate damage, (3) high damage, and (4) severe damage. Scores depict the extent of DNA damage (0 = no tail; 1 = tail length shorter than the diameter of the head [nucleus]; 2 = tail length 1 to 2× the diameter of the head; 3 = tail longer than 2× the diameter of the head; and 4 = completely damaged nucleus) as observed after staining 17,25 …”

Section: Methodsmentioning

confidence: 99%

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Gallic acid: A promising genoprotective and hepatoprotective bioactive compound against cyclophosphamide induced toxicity in mice

Sd¹,

Shenoy

2020

Environmental Toxicology

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Cyclophosphamide (CP) is a potent chemotherapeutic agent and is also known to interact with specific biological molecules and produce numerous side effects such as genotoxicity, neurotoxicity, reproductive toxicity and nephrotoxicity. CP induces genotoxicity by generating oxygen/nitrogen derived free radicals during chemotherapy and causes DNA damage. Hence, to overcome such side effects of chemotherapeutic agents antioxidants are recommended. Gallic acid (GA) a phenolic compound is commonly exists in variety of fruits and in many plants. In the present study, genoprotecive effects of GA against CP induced genotoxicity in Swiss albino mice were evaluated by using comet assay, bone marrow, and peripheral micronucleus (MN) assays. CP produced oxidative stress induced hepatic damage was assessed by estimating the activity of liver superoxide dismutase (SOD), reduced glutathione content (GSH), and also by examining the histological alterations induced by CP in hepatic tissue of mice. It was noticed that, GA pretreatment significantly reduced the frequency of MN and DNA strand breaks induced by CP. GA also protected the hepatic tissue against CP induced reactive oxygen species (ROS) mediated damage and was evident by increased levels of liver SOD and GSH. GA ameliorated the histological changes induced by CP in hepatic tissue. These findings suggest that, GA is a versatile antioxidant with promising protection against CP induced genotoxicity and hepatic damage in Swiss albino mice.

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Section: Introductionsupporting

confidence: 69%

mentioning

confidence: 76%

Section: Methodsmentioning

confidence: 99%

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Gallic acid: A promising genoprotective and hepatoprotective bioactive compound against cyclophosphamide induced toxicity in mice

Sd¹,

Shenoy

2020

Environmental Toxicology

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“…Therefore, we and others have shown that the use of natural molecules such as polyphenols can modulate xenobiotic-metabolizing enzymes as well as the pathways leading to cancer cell death, making it possible to restore sensitization to anticancer agents. For example, resveratrol, curcumin, vitamin E, and gallic acid are able to protect cells from cisplatin-induced genotoxicity [13][14][15]. Very interestingly, some of these natural compounds are able to synergize at the same time with various anticancer drugs.…”

Section: Introductionmentioning

confidence: 99%

Xanthohumol, a Prenylated Flavonoid from Hops, Induces DNA Damages in Colorectal Cancer Cells and Sensitizes SW480 Cells to the SN38 Chemotherapeutic Agent

Scagliarini

Mathey

Aires

et al. 2020

Cells

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In spite of chemotherapy and systematic screening for people at risk, the mortality rate of colorectal cancer (CRC) remains consistently high, with 600,000 deaths per year. This low success rate in the treatment of CRC results from many failures associated with high resistance and the risk of metastasis. Therefore, in response to these therapeutic failures, new strategies have been under development for several years aimed at increasing the effect of anticancer compounds and/or at reducing their secondary effects on normal cells, thus enabling the host to better withstand chemotherapy. This study highlights that xanthohumol (Xn) concentrations under the IC50 values were able to induce apoptosis and to enhance the DNA-damage response (DDR). We demonstrate for the first time that Xn exerts its anticancer activity in models of colon cancer through activation of the ataxia telangiectasia mutated (ATM) pathway. Subsequently, the ability of Xn to restore DNA damage in CRC cells can sensitize them to anticancer agents such as SN38 (7-ethyl-10-hydroxycamptothecin) used in chemotherapy.

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“…7,8 To minimize cisplatin-mediated toxicities and resistance, several combination treatments have been used, wherein two or more drugs/agents with different pharmacological properties are often used. [9][10][11] Flavonoids or bioflavonoids are a category of secondary metabolites of plants and fungal origin. Flavonoids possess a wide range of important biological and pharmacological activities which could be very helpful in promoting human health.…”

Section: Introductionmentioning

confidence: 99%

Modulatory Effect of Rutin on the Antitumor Activity and Genotoxicity of Cisplatin in Tumor-Bearing Mice

Prasad

2020

Adv Pharm Bull

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Purpose: Cisplatin is a cancer chemotherapeutic drug that has been extensively used in the treatment of a variety of cancers. However, the full usage of cisplatin is limited due to its treatment associated development of multiple side effects in the host. In the present study, the modulatory effect of rutin, a type of flavonoid, on the cisplatin mediated antitumor activity and allied genotoxicity in ascites Dalton’s lymphoma (DL)-bearing mice were investigated. Methods: The antitumor activity was determined by calculating the percent increase in the life span of mice, cell viability and scanning electron microscopy of DL cells. Further, the modulatory effect of rutin on the cisplatin-induced genotoxic effects in the same DL-bearing mice was assessed by the analysis of micronuclei, chromosomal aberration and sperm abnormality. Results: The combination treatment of mice with rutin and cisplatin showed a considerable increase in the life span of the DL-bearing mice depicting better antitumor efficacy. Scanning electron microscopy of these DL cells showed severe membrane deformities in DL cells such as fusion of cell membrane, membrane blebbing, cell shrinkage, membrane folding and loss in microvilli from the tumor cell surface which may lead to cell death. Cisplatin alone treatment caused an increase in the frequency of chromosomal aberrations, micronuclei and sperms abnormality. However, the combination treatment of DL-bearing mice with rutin and cisplatin comparatively reduced these genotoxic effects. Conclusion: The overall findings suggest that rutin enhances the cisplatin-mediated antitumor activity and cytotoxicity against DL cells and at the same time diminishes the genotoxic effects induced by cisplatin in the DL-bearing mice.

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Genoprotective effects of gallic acid against cisplatin induced genotoxicity in bone marrow cells of mice

Abstract: Gallic acid is a natural polyhydroxy-phenolic compound. The objective of this study is to evaluate the protective effects of gallic acid against chemotherapeutic drug cisplatin induced damage in bone marrow cells of mice.

Cited by 25 publications

References 29 publications

Gallic acid: A promising genoprotective and hepatoprotective bioactive compound against cyclophosphamide induced toxicity in mice

Gallic acid: A promising genoprotective and hepatoprotective bioactive compound against cyclophosphamide induced toxicity in mice

Xanthohumol, a Prenylated Flavonoid from Hops, Induces DNA Damages in Colorectal Cancer Cells and Sensitizes SW480 Cells to the SN38 Chemotherapeutic Agent

Modulatory Effect of Rutin on the Antitumor Activity and Genotoxicity of Cisplatin in Tumor-Bearing Mice

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