Genotoxic and carcinogenic effects of non-ionizing electromagnetic fields

Kocaman, Adem; Altun, Gamze; Kaplan, Arife Ahsen; Deniz, Ömür Gülsüm; Yurt, Kıymet Kübra; Kaplan, Süleyman

doi:10.1016/j.envres.2018.01.034

Cited by 51 publications

(21 citation statements)

References 93 publications

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“…The anxiety and speculation about potential health hazards caused by microwave radiation, nonionizing electromagnetic radiation ranging from 300 MHz to 300 GHz, has been growing fast in recent years 24 . Our group and others have been focusing on the biological effects of microwave exposure and its mechanisms 5 , 18 , 21 – 23 , 25 – 28 .…”

Section: Discussionmentioning

confidence: 99%

HIF-1α regulates COXIV subunits, a potential mechanism of self-protective response to microwave induced mitochondrial damages in neurons

Hao¹,

Zhang²,

Wang³

et al. 2018

Sci Rep

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Anxiety and speculation about potential health hazards of microwaves exposure are spreading in the past decades. Hypoxia-inducible factor-1α (HIF-1α), which can be activated by reactive oxygen species (ROS), played pivotal roles in protective responses against microwave in neuron-like cells. In this study, we established 30 mW/cm2 microwave exposed animal model, which could result in revisable injuries of neuronal mitochondria, including ultrastructure and functions, such as ROS generation and cytochrome c oxidase (COX) activity. We found that the ratio of COXIV-1/COXIV-2, two isoforms of COXIV, decreased at 1 d and increased from 3 d to 14 d. Similar expression changes of HIF-1α suggested that COXIV-1 and COXIV-2 might be regulated by HIF-1α. In neuron-like cells, 30 mW/cm2 microwave down-regulated COX activity from 30 min to 6 h, and then started to recover. And, both HIF-1α transcriptional activity and COXIV-1/COXIV-2 ratio were up-regulated at 6 h and 9 h after exposure. Moreover, HIF-1α inhibition down-regulated COXIV-1 expression, promoted ROS generation, impaired mitochondrial membrane potentials (MMP), as well as abolished microwave induced ATP production. In conclusion, microwave induced mitochondrial ROS production activated HIF-1α and regulated COXIV-1 expression to restore mitochondria functions. Therefore, HIF-1α might be a potential target to impair microwave induced injuries.

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Section: Discussionmentioning

confidence: 99%

HIF-1α regulates COXIV subunits, a potential mechanism of self-protective response to microwave induced mitochondrial damages in neurons

Hao¹,

Zhang²,

Wang³

et al. 2018

Sci Rep

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“…Eine neuer Review zur Gesamtstudienlage von Kocaman et al [48] kommt zu dem Schluss: "Es ist gut dokumentiert, dass eine EMF-Exposition indirekte schädliche Auswirkungen durch DNA-Schäden, DNA-Brüche und oxidativen Stress haben kann. Bei sehr kurzer Dauer und niedrigen Frequenzen der nichtionisierenden Strahlenbelastung können Auswirkungen ausbleiben."…”

Section: Wlan: Auswirkungen Auf Gehirn Fruchtbarkeit Embryonen Dnaunclassified

Risiko Mobilfunk

Hensinger¹

2018

Deutsche Heilpraktiker-Zeitschrift

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SummaryWLAN und Mobilfunk wurden von Industrie und Politik konsequent in alle Lebensbereiche eingeführt, vom Klassen bis zum Schlafzimmer, mit gesundheitlichen Folgen. Beispielhaft für die eindeutige Studienlage wertet der Beitrag über 50 wissenschaftliche Publikationen aus, die signifikante Gesundheitsschäden durch WLAN und Mobilfunk feststellen, insbesondere durch oxidativen Stress. Zu den dokumentierten Mobilfunkfolgen zählen Tumoren unter anderem des Gehirns, Unfruchtbarkeit, Erbgutschäden und Burnout.

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“…It should be noted that the severity of these complications depends on the duration of the calls and the frequency of use of the mobile phone (9) . Also, the waves emitted from mobile phones can cause a genetic defect or lead to cancer by affecting chromosomes (10)(11)(12) .…”

Section: Introductionmentioning

confidence: 99%

The effect of mobile phone waves on salivary secretion in dental students of Rafsanjan University of Medical Sciences

et al. 2021

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Background: Excessive use of mobile phones is addictive and causes many complications. The severity of these complications depends on the duration of the call and the frequency of using mobile phones. Therefore, this study aimed to determine the effect of mobile phone waves on salivary secretion. Materials and Methods: This descriptive study was conducted on 120 dental students in Rafsanjan, Iran, in 2015. Using the call history of the mobile phones, the number and duration of each person's daily calls were obtained. The spitting method was used to collect unstimulated saliva, and stimulated saliva was collected with the help of natural chewing gums without sugar and additive flavors. After sampling, the falcon tubes containing saliva were centrifuged at 2500 rpm for 10 minutes. Then the saliva volume was read from the tube and recorded. Independent two-sample t test, one-way ANOVA, and multiple linear regression model were used for data analysis. Results: Students who talked for more than 40 minutes or 20-40 minutes a day on their mobile phones had a mean unstimulated salivary secretion of 0.885 and 0.331 ml/min, respectively and mean stimulated salivary secretion of 0.702 and 0.708 ml/min, respectively more than students who talked less than 20 minutes a day on their cell phones (P<0.05). Conclusion: The results showed that increased duration of cell phone calls was associated with increasing the amount of stimulated and unstimulated salivary secretion, which could decrease the risk of developing oral infections and tooth decay.

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Genotoxic and carcinogenic effects of non-ionizing electromagnetic fields

Cited by 51 publications

References 93 publications

HIF-1α regulates COXIV subunits, a potential mechanism of self-protective response to microwave induced mitochondrial damages in neurons

HIF-1α regulates COXIV subunits, a potential mechanism of self-protective response to microwave induced mitochondrial damages in neurons

Risiko Mobilfunk

The effect of mobile phone waves on salivary secretion in dental students of Rafsanjan University of Medical Sciences

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