Genotoxic effect of Lippia alba (Mill.) N. E. Brown essential oil on fish ( Oreochromis niloticus ) and mammal (Mus musculus )

Kampke, Edgar Hell; Barroso, Maria Eduarda de Souza; Marques, Franciane Martins; Scherer, Rodrigo; Lemos, Mayara Fumiere; Campagnaro, Bianca Prandi; Gomes, Levy Carvalho

doi:10.1016/j.etap.2018.03.016

Cited by 20 publications

(4 citation statements)

References 43 publications

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“…As a result, they get able to catch more fishes compared to other usual fish tracks. It has been scientifically proved that essential oil of Lippia alba has sedative properties which act as an anesthetic for fish without harm to consumers [32] . Hence, this plant helps the fishermen with this unique property.…”

Section: Discussionmentioning

confidence: 99%

Ethnomedicinal and ethnobotanical uses of aquatic flora by local inhabitants of Gopalganj District, Bangladesh

Maisha,

Jui,

Begum

2024

J. Med. Plants Stud.

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The current work was intended to carry out ethnomedicinal research of aquatic flora or hydrophytes in Gopalganj district, Bangladesh in order to gather evidence of its therapeutic benefits through conversations with the local residents and practitioners. Extensive empirical surveys were conducted on frequently to gather samples of aquatic plants and interviews with local inhabitants and herbalists were accomplished during November 2022 -November 2023. Documentation was done on the fundamentals of traditional applications of medicinal plant as well as their various ethnobotanical purposes. An aggregate of 60 plant species belonging to 33 families were identified as having ethnomedical uses in the treatment of various human illnesses and ailments, including skin conditions, asthma, gonorrhea, ulcers, stomach pain, and piles. These hydrophytes were found to play vital functions in material culture, agricultural purposes and ritual manners. Wetland resources, particularly those with ethnomedicinal and ethnobotanical significance require care because the existence of these natural wetlands species is in jeopardy.

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Section: Discussionmentioning

confidence: 99%

Ethnomedicinal and ethnobotanical uses of aquatic flora by local inhabitants of Gopalganj District, Bangladesh

Maisha,

Jui,

Begum

2024

J. Med. Plants Stud.

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“…Moreover, to demonstrate the full safety of the anesthetic, in addition to the parameters evaluated in the present study, a battery of genotoxicity indicators is under assessment. The goal is to evaluate the possible induction of genetic damage in exposed individuals [49], or in end consumers [50,51]. A comparison between a number of synthetic (e.g., benzocaine) and natural (e.g., eugenol) anesthetics showed that both might induce genotoxic effects in freshwater fish species [52].…”

Section: Discussionmentioning

confidence: 99%

“…Thus, an evaluation of doses to avoid genotoxicity is needed in order to reach the market [53]. For instance, Lippia alba essential oil was considered safe for fish and end consumers after the assessment of its genotoxicity [50,51].…”

Section: Discussionmentioning

confidence: 99%

Physiological Response of Atlantic Salmon (Salmo salar) to Long-Term Exposure to an Anesthetic Obtained from Heterosigma akashiwo

Gonçalves

Llanos-Rivera

Ruano

et al. 2022

Toxins

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Despite the invaluable role of anesthetics as a tool for ensuring animal welfare in stressful situations, there is currently a lack of anesthetic drugs that meet the requirements of intensive aquaculture. In response to the growing interest in anesthetic substances of natural origin, this study evaluated the physiological and health impact of an anesthetic based on an extract of the microalga Heterosigma akashiwo on juvenile salmon (Salmo salar) exposed for a period of 72 h. To simulate a condition closer to reality where fish are subjected to stimuli (e.g., transport), the animals were exposed to 50 mg L−1 of algal extract and to physical stress. Functional, physiological, and histological parameters were evaluated in blood and tissues at different sampling periods (0, 24, and 72 h). There was no mortality and the induction and recovery times observed were within the established criteria for anesthetic efficacy. The anesthetic extract did not induce any side effects, such as stress or metabolic damage, indicating that this extract is a viable option for supporting fish welfare during deleterious events. This study provides information to support that the anesthetic extract tested, derived from H. akashiwo, is a promising candidate drug for operations requiring sedation (e.g., Salmonid transport).

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“…It is popularly known as lemon herb balm, Brazilian lemon balm, False-Melissa, Carmelite lemon balm, common lemon balm tea, field lemon balm and bush matgrass, among others [ 3 , 4 ]. The essential oil of this species is described as antibacterial [ 5 , 6 , 7 ], antifungal [ 8 , 9 , 10 , 11 ], anxiolytic, anticonvulsant [ 12 , 13 ], anesthetic [ 14 , 15 , 16 ], and smooth muscle relaxant [ 17 , 18 , 19 , 20 ]. Moreover, in folk medicine, this species is used to control blood pressure, as a calmant, and to treat respiratory diseases [ 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Lippia alba (Mill.) N.E. Brown Essential Oil on the Human Umbilical Artery

Borges

Bastos

Dantas

et al. 2022

Plants

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Lippia alba is popularly known as lemon balm, with its essential oil (EO) cited for displaying antimicrobial, sedative, and vasorelaxant effects. Yet, its action on isolated human vessels has not been described in the literature. Thus, we evaluated the vasorelaxant effect of essential oil of L. alba (EOLa) on human umbilical arteries (HUA) isolated in organ baths. HUA rings were isolated, subjected to contractions induced by potassium chloride (KCl), serotonin (5-HT), or histamine (HIST) to record the isometric tension, and then treated with EOLa (30–1000 µg/mL). The EOLa showed a more prominent inhibitory effect on the pharmacomechanical coupling contraction via HIST with an EC50 value of 277.1 ± 8.5 µg/mL and maximum relaxant effect at 600 µg/mL. The addition of tetraethylammonium (TEA) or 4-aminopyridine (4-AP) in HUA preparations did not inhibit EOLa total relaxant effect at 1000 µg/mL. In the presence of gliblenclamide (GLI), the oil relaxed the HUA rings by 90.8% at maximum concentration. The EOLa was also investigated for its effects on voltage-operated calcium channels (VOCCs), where the HUA preincubation with this oil at 1000 μg/mL inhibited BaCl2 (0.1–30 mM)-induced contractions. This study demonstrates for the first time that EOla has a vasorelaxant effect on HUA and its particular blockade of VOCCs.

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Genotoxic effect of Lippia alba (Mill.) N. E. Brown essential oil on fish ( Oreochromis niloticus ) and mammal (Mus musculus )

Cited by 20 publications

References 43 publications

Ethnomedicinal and ethnobotanical uses of aquatic flora by local inhabitants of Gopalganj District, Bangladesh

Ethnomedicinal and ethnobotanical uses of aquatic flora by local inhabitants of Gopalganj District, Bangladesh

Physiological Response of Atlantic Salmon (Salmo salar) to Long-Term Exposure to an Anesthetic Obtained from Heterosigma akashiwo

Effect of Lippia alba (Mill.) N.E. Brown Essential Oil on the Human Umbilical Artery

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