Genotoxic effects and chemical compositions of four creosotes

Nylund, L.; Heikkilä, Pirjo; Hämeilä, Mervi; Pyy, Lauri; Linnainmaa, Kaija; Sorsa, Marja

doi:10.1016/0027-5107(92)90051-3

Cited by 44 publications

(19 citation statements)

References 23 publications

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“…It contains hundreds of compounds, of which about 100 have been identified and quantified (1). It has about 20 major constituents with concentrations of more than 1% each (amounting to about 80% of the total) (2). Creosote can cause skin irritation and photosensitization, and the International Agency for Research on Cancer has determined that there is sufficient evidence for the carcinogenicity of creosote to animals but limited evidence to humans (3).…”

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confidence: 99%

“…A recent study showed an increased risk of skin cancer among creosote-exposed workers (4). The highest boiling fractions were shown to contain mutagenic compounds (2). DNA (deoxyribonucleic acid) adducts of polycyclic aromatic hydrocarbons (PAH) have been detected in the skin and lungs of mice after topical application of creosote to the skin of experimental animals (5).…”

mentioning

confidence: 99%

“…Naphthalene is the most abundant component of creosote vapor (6), and it constitutes 10-16 weight-% of creosote oils (2). Naphthalene is a major airborne impurity also in occupational exposures related to the processing or handling of products with a coal tar and mineral oil base (7, 8, 9, lo), and even in cooking fumes (1 1).…”

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confidence: 99%

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Urinary 1-naphthol excretion in the assessment of exposure to creosote in an impregnation facility

Heikkilä

Luotamo²,

Riihimäki³

1997

Scand J Work Environ Health

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confidence: 99%

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confidence: 99%

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Urinary 1-naphthol excretion in the assessment of exposure to creosote in an impregnation facility

Heikkilä

Luotamo²,

Riihimäki³

1997

Scand J Work Environ Health

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“…Using the same bioassay method, urine samples of three workers in the creosote wood-preserving industry were not mutagenic although organic extracts of wipe-test samples from the surfaces of their work environments were (Bos et al, 1984a). Several creosote samples induced sister chromatid exchange in Chinese hamster ovary cells in the presence of an Aroclor 1254-induced rat liver metabolic activation system (Nylund et al, 1992). Creosote applied topically to mouse skin in vivo or human skin in short-term organ culture produced a complex pattern of aromatic DNA adducts with similar levels in both systems (Schoket et al, 1988a,b).…”

Section: (C) Creosotementioning

confidence: 99%

“…A portion of the mutagenicity was attributed to benzo [a]pyrene, benz [a]anthracene and fluoranthene in the complex mixture (Bos et al, 1984a(Bos et al, , 1987. Four creosotes used in Finland were mutagenic in S. typhimurium TA98 , TA100, YG1021 and YG1024 in the presence of an Aroclor 1254-induced rat liver metabolic activation system (Nylund et al, 1992). The urine from rats treated with creosote by intraperitoneal administration was mutagenic in S. typhimurium TA98 and TA100 in the presence of an Aroclor 1254-induced rat liver homogenate supplemented with β-glucuronidase (Bos et al, 1984b).…”

Section: (C) Creosotementioning

confidence: 99%

Integrating Field Analyses with Laboratory Exposures to Assess Ecosystems Health

Hellou¹,

Beach²,

Leonard³

et al. 2012

Polycyclic Aromatic Compounds

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initiated a programme on the evaluation of the carcinogenic risk of chemicals to humans involving the production of critically evaluated monographs on individual chemicals. The programme was subsequently expanded to include evaluations of carcinogenic risks associated with exposures to complex mixtures, life-style factors and biological and physical agents, as well as those in specific occupations. The objective of the programme is to elaborate and publish in the form of monographs critical reviews of data on carcinogenicity for agents to which humans are known to be exposed and on specific exposure situations; to evaluate these data in terms of human risk with the help of international working groups of experts in chemical carcinogenesis Publications of the World Health Organization enjoy copyright protection in accordance with the provisions of Protocol 2 of the Universal Copyright Convention. All rights reserved.The International Agency for Research on Cancer welcomes requests for permission to reproduce or translate its publications, in part or in full. Requests for permission to reproduce or translate IARC publications -whether for sale or for noncommercial distribution -should be addressed to WHO Press, at the above address (fax: +41 22 791 4806; email: permissions@who.int).The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the World Health Organization concerning the legal status of any country, territory, city, or area or of its authorities, or concerning the delimitation of its frontiers or boundaries.The mention of specific companies or of certain manufacturers' products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters.The IARC Monographs Working Group alone is responsible for the views expressed in this publication. IARC Library Cataloguing in Publication Data NOTE TO THE READERThe term 'carcinogenic risk' in the IARC Monographs series is taken to mean that an agent is capable of causing cancer under some circumstances. The Monographs evaluate cancer hazards, despite the historical presence of the word 'risks' in the title.Inclusion of an agent in the Monographs does not imply that it is a carcinogen, only that the published data have been examined. Equally, the fact that an agent has not yet been evaluated in a Monograph does not mean that it is not carcinogenic.The evaluations of carcinogenic risk are made by international working groups of independent scientists and are qualitative in nature. No recommendation is given for regulation or legislation.Anyone who is aware of published data that may alter the evaluation of the carcinogenic risk of an agent to humans is encouraged to make this information available to the Section of IARC Monographs, International Agency for...

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SOS chromotest results in a broader context: Empirical relationships between genotoxic potency, mutagenic potency, and carcinogenic potency

White

Rasmussen

1996

Environ. Mol. Mutagen.

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Genotoxic effects and chemical compositions of four creosotes

Cited by 44 publications

References 23 publications

Urinary 1-naphthol excretion in the assessment of exposure to creosote in an impregnation facility

Urinary 1-naphthol excretion in the assessment of exposure to creosote in an impregnation facility

Integrating Field Analyses with Laboratory Exposures to Assess Ecosystems Health

SOS chromotest results in a broader context: Empirical relationships between genotoxic potency, mutagenic potency, and carcinogenic potency

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