Genotoxic Effects of Avenoxan onAllium cepa L.andAllium sativum L.

Tartar, Gul; Kaymak, Fisun; Gökalp, Fulya Dilek

doi:10.1080/00087114.2006.10797921

Cited by 21 publications

(11 citation statements)

References 21 publications

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“…On the other hand the inhibition of certain cell cycle specific proteins remains as a possible herbicide target site. Thus, inhibition of enzyme DNA polymerase which is necessary for the synthesis of DNA precursors as well as other enzymes more directly involved with spindle production, assembly or orientation could explain the reported antimitotic effect (Tartar et al, 2006). Therefore, these processes explained the inhibitory effect of amitraz pesticides induced in Allium plant-system in the present study.…”

Section: Mean Root Length Growth Inhibition and Mitotic Indices Of Asupporting

confidence: 50%

Evaluation of the Cytogenotoxic Effects of Emulsifiable Concentrate form of Amitraz Pesticide on Allium cepa L

Adesuyi¹,

Njoku²,

Ogunyebi³

et al. 2019

Journal of Applied Sciences and Environmental Management

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The cytogenotoxic effects of emulsifiable concentrate of amitraz pesticides was evaluated using Allium cepa L. test. The root meristems of A. cepa L. were treated with five concentrations (1%, 5%, 10%, 20% and 40%) of the chemical pesticide at 48 h for cytogenetic analyses and 96 h for root length inhibition. Pesticide doses affected root length significantly (P<0.05) at 5% to 40%; with 50% effective concentration (EC50) value of 18% while there was no significant difference between control and 1% (p>0.05). The mean root length of the treated A. cepa for Amitraz pesticides in all concentrations was lower compared to the control showing the obvious mitodepressive effects of amitraz pesticides. A dose dependent reduction in the total mitotic dividing cells and mitotic index was observed in A. cepa treated with the pesticides. The values of mitotic index obtained for amitraz pesticides at 5% (5.20), 10% (4.0), 20% (2.30) and 40% (0.80) were lower than half of the negative control (7.25), which reflect its cytotoxicity. All the concentrations of the pesticides used in the present study induced important abnormalities during mitotic division. These aberrations were: chromosome stickiness, disturbed spindle, anaphase and telophase bridges, chromosome fragments, laggard chromosomes, and c-Mitosis. The highest abnormality number was observed in the root tips of Allium cepa (5%) while the least was at 40%. Frequencies of chromosome abnormalities were low at 20% and 40% concentration because of damaged cell and lower cell divisions. The present study, showed the inhibition of growth and induction of chromosomal aberrations by amitraz, this suggest their capability in inducing cytotoxicity and genome instability.

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Section: Mean Root Length Growth Inhibition and Mitotic Indices Of Asupporting

confidence: 50%

Evaluation of the Cytogenotoxic Effects of Emulsifiable Concentrate form of Amitraz Pesticide on Allium cepa L

Adesuyi¹,

Njoku²,

Ogunyebi³

et al. 2019

Journal of Applied Sciences and Environmental Management

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show abstract

“…These results indicate the potential of these agents to induce mitotic irregularities, as observed by few earlier studies (Abdelsalam et al 1997;Siddiqui et al 2009). The chromosomal aberration induced by these herbicides could be due to their inhibitory action on spindle proteins and also their ability to induce sister chromatid exchange (Barbara et al 1991;Grossmann et al 2001;Claudio et al 1992;Tartar et al 2006;Gichner et al 2002).…”

Section: Resultsmentioning

confidence: 99%

Glyphosate, Alachor and Maleic Hydrazide have Genotoxic Effect on Trigonella foenum-graecum L.

Siddiqui

Meghvansi

Khan³

2012

Bull Environ Contam Toxicol

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In the present study effects of herbicides glyphosate (GP), alachlor (AL) and maleic hydrazide (MH) is studied on mitotic cells of Trigonella foenum-graecum L. Seeds of T. foenum-graecum L. treated with a series of concentrations ranging from 0.1%, 0.2%, 0.3%, 0.4% and 0.5% for 1, 2 and 6 h and their effect on mitotic index and chromosomal aberrations was studied. The results indicate that these herbicides reduced mitotic index in dose-dependent manner. In addition, increase in the percentage of abnormal mitotic plates was observed in herbicide treated groups which was both concentration and time dependent. Commonly observed abnormalities were c-mitosis, laggards, bridges, stickiness, c-anaphase, precocious separation, un-equal distribution and fragments. The result of the present investigation indicates that commonly used herbicides GP, AL and MH have significant genotoxic effect on T. foenum-graecum plant.

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“…At 48 h treatment period, 0.67 and 2.68 mg/L concentrations induced lagging chromosomes with the frequency of 0.37 and 0.15, respectively. Lagging chromosomes arise mainly due to abnormal spindle formation and as a result, spindle fibre failed to carry respective chromosomes to the polar regions with appearance of lagging chromosomes (Tarar and Dyansagar 1980;Tartar et al 2006;Pulate and Tarar 2014).…”

Section: Resultsmentioning

confidence: 99%

Does 2,4-dichlorophenoxyacetic acid (2,4-D) induce genotoxic effects in tissue cultured Allium roots?

et al. 2016

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2,4-Dichlorophenoxyacetic acid (2,4-D) is a synthetic plant growth regulator that is highly toxic to most broad leaved plants and relatively nontoxic to monocotyledonous plants; is frequently used as weed killer. The study aimed to investigate cytogenetic effects of different concentrations of 2,4-D (0.67, 1.34, 2.01, 2.68, 3.35 and 4.02 mg/L) on Allium cepa bulblets' root tips treated for 24 and 48 h. The results showed six types of structural aberrations: C-mitosis, stickiness, laggards, bridges, fragments and multipolarity that varied numerically compared to control. It significantly affected mitotic index (MI) at 24 and 48 h treatment. In the Allium test, MI increased significantly at three lower concentrations (0.67, 1.34, 2.01 mg/L) after treatment with 2,4-D for 24 h and decreased significantly at higher concentration. Whereas, 2,4-D treatment for 48 h increased MI at all concentrations with significantly decreased MI at the highest concentration. The experiment was extended using comet test that did not reveal significant difference among treatments except for application of 4.02 mg/L 2,4-D for 48 h; where cell damages were verified by comet test. Rest of the concentrations for any duration of time were not damaging and toxic to cells. The results showed, visible mitodepressive action of 4.02 mg/L 2,4-D when treated for 48 h that had tendency to become toxic if the roots had been in touch with 2,4-D for a longer time.

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Genotoxic Effects of Avenoxan onAllium cepa L.andAllium sativum L.

Cited by 21 publications

References 21 publications

Evaluation of the Cytogenotoxic Effects of Emulsifiable Concentrate form of Amitraz Pesticide on <i>Allium cepa</i> L

Evaluation of the Cytogenotoxic Effects of Emulsifiable Concentrate form of Amitraz Pesticide on <i>Allium cepa</i> L

Glyphosate, Alachor and Maleic Hydrazide have Genotoxic Effect on Trigonella foenum-graecum L.

Does 2,4-dichlorophenoxyacetic acid (2,4-D) induce genotoxic effects in tissue cultured Allium roots?

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