Genotoxic effects produced by capsaicin in mouse during subchronic treatment

Arceo, Sandra Díaz Barriga; Madrigal-Bujaidar, Eduardo; Montellano, E. Calderón; Herrera, Luis Alberto Petit; García, B.D. Díaz

doi:10.1016/0165-1218(95)90046-2

Cited by 29 publications

(13 citation statements)

References 17 publications

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“…Stock concentration of lycopene was 200 g/ml and the dose of lycopene was 2 mg/kg [26] as suggested in previous studies. The dose of capsaicin selected was 2 mg/kg based on previous studies [31]. Our pilot studies showed that capsaicin was capable of inducing mutagenesis at a dose of 2 mg/kg, orally, for 32 days.…”

Section: Subjectsmentioning

confidence: 98%

“…The intake of capsaicinoids in Asian countries is estimated to be 25-200 mg/person/day as capsaicin accounts for 80% of the content in capsicum fruits [3,4] Capsaicin is aptly referred to as a 'double edged sword' as it possesses both genotoxic and chemopreventive potential [5]. Capsaicin readily evokes the formation of micronuclei and promotes sister chromatid exchange in mice [6,7]. Excessive and frequent consumption of Capsicum leads to organic disturbances in the digestive tract [8] characterized by duodenal [9] and gastric tumors [10].…”

Section: Introductionmentioning

confidence: 99%

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Impact of zinc, selenium and lycopene on capsaicin induced mutagenicity and oxidative damage in mice

Banji¹,

Banji²,

Reddy³

et al. 2013

Journal of Trace Elements in Medicine and Biology

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Section: Subjectsmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Impact of zinc, selenium and lycopene on capsaicin induced mutagenicity and oxidative damage in mice

Banji¹,

Banji²,

Reddy³

et al. 2013

Journal of Trace Elements in Medicine and Biology

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“…CAP is aptly referred as a 'double edged sword' as it possesses both a genotoxic and a chemopreventive potential (Surh and Lee 1995). CAP readily evokes the formation of micronuclei and promotes sister chromatid exchange in mice (Diaz Barriga-Areos et al 1995;Lee and Cho 1997). Excessive and frequent consumption of capsicum leads to organic disturbances in the digestive tract (Sanghvi 1981) characterized by duodenal (Toth and Gannett 1992) and gastric tumors (Agarwal et al 1986;Banji et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Protective effect of (−)-epigallocatechin-3-gallate on capsaicin-induced DNA damage and oxidative stress in human erythrocyes and leucocytes in vitro

Pandır

2014

Cytotechnology

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The aim of this study is to show that protective effects of the main catechin (-)-epigallocatechin-3-gallate (EGCG) against capsaicin (CAP) induced oxidative stress and DNA damage in human blood in vitro. Superoxide dismutase, catalase, glutathione peroxidase and malondialdehyde (MDA) level were studied in erythrocytes and leucocytes with increased concentrations of CAP. DNA damage in leucocytes was measured by the comet assay. Human blood cells have been administered with doses between 0 and 200 μM of CAP and/or EGCG (20 μM) for an hour at 37 °C. Treatment with CAP alone has increased the levels of MDA and decreased antioxidant enzymes in human blood cells. A significant increase in tail DNA%, mean tail length and tail moment indicating DNA damage has been observed at the highest dose of CAP treatment when compared to controls. Treatment of cells with CAP plus EGCG prevented CAP-induced changes in antioxidant enzyme activities and MDA level and mean tail lenght indicating DNA damage. A significant increase in mean tail lenght was observed at high doses of CAP. These data suggest that EGCG can prevent toxicity to human erythrocytes and leucocytes caused by CAP, only at low doses.

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“…Capsaicin was not mutagenic or had a weak mutagenic response in the Ames test [50][51][52][53]. Capsaicin increased bone marrow cells in rats [51,54], but was not mutagenic [55]. In fact, AFs in natural foods are also not mutagenic, thus, these results were consistent.…”

Section: Discussionmentioning

confidence: 81%

Presence of Aflatoxins (Mutagens and Carcinogens) in Industrialized Chili Sauces

HG¹,

M²

2016

Pharm Anal Acta

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Aflatoxins (AFs) are the most frequent mutagens, teratogens and carcinogens detected in food, and they are also present in all types of chili peppers and sauces made with them. Fifty-two different industrialized chili pepper sauces from markets in Mexico were analyzed for the presence of aflatoxins (AFB1, AFB2, AFG1 and AFG2). The chemical AF extraction and high performance liquid chromatography methods were validated based on the following parameters: selectivity, linearity (calibration curves), recovery percentages, limits of detection (LOD) and quantification (LOQ). The square of correlation coefficients (R2) were AFB1: 0.9973; AFB2: 0.9892; AFG: 0.9969; and AFG2: 0.9986. All curves were correct, with an average regression coefficient of R2 > 0.9892. The percentage of recovery, was 83% for AFB1 , 75% for AFB2, 96% for AFG1, and 81% for AFG2. The Limits of Detection (LOD) were 0.1 ng for AFB1, 0.01 ng for AFB2, 0.01 ng for AFG1, and 0.5 ng for AFG2.For the statistical analysis, the different chili sauce groups were analyzed and compared using a Kruskal-Wallis test, and the results showed no statistically significant differences among the samples with respect to the total aflatoxins (AFt) amounts. The removal of all high mutagenic levels of AFG1 (> 10 ppb) from the analysis did not change the results. Eight chili pepper sauces (15%) from the different groups surpassed the 10 ppb AFt tolerance limit of the Codex Alimentarius and had 15 to 116 µg kg-1 AFt. The average AFt from the 52 samples was 3.69 µg kg-1, which were all within the globally accepted limits. Thus, these results suggest that there is no consistent basis for warning the public about AFs in the most commonly used salsas, but their use should be moderated because many are not safe to eat. PAA, an open access journal Volume 7 • Issue 5 • 1000477Patients with psoriatic lesions are unresponsive to low capsaicin concentrations [61]. Capsaicin cream also showed good results for the Citation: Carvajal-Domínguez HG, Carvajal-Moreno M, Ruiz-Velasco S, Alvarez-Bañuelos MT (2016) Presence of Aflatoxins (Mutagens and

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Genotoxic effects produced by capsaicin in mouse during subchronic treatment

Cited by 29 publications

References 17 publications

Impact of zinc, selenium and lycopene on capsaicin induced mutagenicity and oxidative damage in mice

Impact of zinc, selenium and lycopene on capsaicin induced mutagenicity and oxidative damage in mice

Protective effect of (−)-epigallocatechin-3-gallate on capsaicin-induced DNA damage and oxidative stress in human erythrocyes and leucocytes in vitro

Presence of Aflatoxins (Mutagens and Carcinogens) in Industrialized Chili Sauces

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