Genotoxic potential of an organophosphate insecticide, phosphamidon (Dimecron): An in vivo study in mice

Behera, B.C.; Bhunya, Sourav

doi:10.1016/0378-4274(87)90142-1

Cited by 16 publications

(4 citation statements)

References 24 publications

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“…Occupational exposures to pesticides could diminish or destroy the fertility of workers sparked a concern about the effects of hazardous substances on male reproductive health. The issue of testicular toxicity is of growing concern as a large number of Organophosphates viz., Dimethoate (Salem, 1988), Phorate (Saxena and Sarin, 1980), Phosphamidon (Behera and Bunya, 1987), Diazinon (US Department, 1994), Malathion (Balasubramanian, 1987) and Methyl Parathion (Mathew et al, 1992;Joshi et al, 2003) adversely affect the testicular functions in experimental animals. Owing to the extensive use of organophosphate pesticides in agriculture there is a high risk of human exposure to these chemicals (Weiss, 1997;Sarkar et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Testicular toxicity of chlorpyrifos (an organophosphate pesticide) in albino rat

2007

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Organophosphates are among the most widely used synthetic insect pesticides. The widespread use of organophosphates has stimulated research into the possible existence of effects related with their reproductive toxic activity. Present study was therefore, undertaken to assess the effects of chlorpyrifos on testes, the main organ of male reproduction. Chlorpyrifos at the dose levels of 7.5, 12.5 and 17.5 mg/kg b. wt./day was administered orally to male rats of Wistar strain for 30 days to evaluate the toxic alterations in testicular histology, biochemistry, sperm dynamics and testosterone levels. The body weight of animals did not show any significant change, however, a significant reduction was observed in testes. Chlorpyrifos also brought about marked reduction in epididymal and testicular sperm counts in exposed males and a decrease in serum testosterone concentration. Histopathological examination of testes showed mild to severe degenerative changes in seminiferous tubules at various dose levels. Fertility test showed 85% negative results. A significant reduction in the sialic acid content of testes and testicular glycogen was noticed, whereas the protein and cholesterol content was raised at significant levels. All these toxic effects are moderate at low doses and become severe at higher dose levels. From the results of the present study it is concluded that chlorpyrifos induces severe testicular damage and results in reduction in sperm count and thus affect fertility. Small changes in sperm counts are known to have adverse affects on human fertility. Therefore, application of such insecticide should be limited to a designed programme.

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Section: Introductionmentioning

confidence: 99%

Testicular toxicity of chlorpyrifos (an organophosphate pesticide) in albino rat

2007

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“…To compare the mutagenic frequency of different experimental groups the proportion test (Z-test) was performed (Behera and Bhunya 1987). Data scoring was done irrespective of assays from slides under code.…”

Section: Discussionmentioning

confidence: 99%

Genotoxic Effect of a Preservative, Sodium Metabisulphite as Revealed by Mammalian in vivo Bioassays.

Pal

Bhunya

1992

CYTOLOGIA

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“…10). Somers and Hu (1962), Behera and Bhunya (1987), Bhunya and Behura (1987) and Pati and Bhunya (1987). Kost (1949), Sobes (1956), Smith (1966) and Pandit (1986) have reported genotoxic potential of different mutagens and chromosomal aberrations such as stretching, breakages, clumping, bridges and extreme fragmentation.…”

Section: Resultsmentioning

confidence: 99%

Genotoxic Effect of Chlorpyriphos on Germ Cells of Short Horned Grasshopper Poecilocerus pictus F. (Insecta: Orthoptera: Acridiidae)

et al. 2007

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SummaryThe long term exposure of living organisms to pesticidal residues present in our environment leads to several health hazards, of which genotoxity is of prime importance. The investigation on the effect of organophosphorous compound namely Chlorpyriphos on grasshoppers shows that Chlorpyriphos has induced chromosomal aberrations significantly with increase in concentration and duration of exposure to this compound. Hence, careful and controlled use of the stated pesticide is suggested.

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Genotoxic potential of an organophosphate insecticide, phosphamidon (Dimecron): An in vivo study in mice

Cited by 16 publications

References 24 publications

Testicular toxicity of chlorpyrifos (an organophosphate pesticide) in albino rat

Testicular toxicity of chlorpyrifos (an organophosphate pesticide) in albino rat

Genotoxic Effect of a Preservative, Sodium Metabisulphite as Revealed by Mammalian in vivo Bioassays.

Genotoxic Effect of Chlorpyriphos on Germ Cells of Short Horned Grasshopper Poecilocerus pictus F. (Insecta: Orthoptera: Acridiidae)

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