Genotoxic Potential of the Insecticide Imidacloprid in a Non-Target Organism (&amp;lt;i&amp;gt;Oreochromis niloticus&amp;lt;/i&amp;gt;-Pisces)

Ansoar-Rodríguez, Yadira; Christofoletti, Cintya Aparecida; Marcato, A.C.C.; Correia, Jorge Evangelista; Bueno, Odair Corrêa; Malaspina, Osmar; Fontanetti, Carmem Silvia

doi:10.4236/jep.2015.612118

Cited by 23 publications

(5 citation statements)

References 38 publications

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“…On the other hand, histological research indicates that exposure to imidacloprid resulted in disorganized lobules and cyst structures in adult loach fish (Xia et al, 2016) and a moderate‐to‐severe damaging in gills and kidney of adult Oreochromis mossambicus and Labeo rohita fish (Patel et al, 2016). Additionally, imidacloprid genotoxicity is concerned, the erythrocyte micronuclei assays and the comet assay showed that imidacloprid has genetic toxic effect on erythrocytes of the loach (Patel et al, 2016), Chinese rare minnows (Iturburu et al, 2018a), Neotropical fish (Vieira et al, 2018), Nile tilapia (Ansoar‐Rodríguez et al, 2015), Chameleon cichlid (Iturburu et al, 2018b), freshwater teleost (Alvim & dos Reis Martinez, 2019) and tadpoles (Pérez‐Iglesias et al, 2014). The short‐term exposures to environment contaminated with imidacloprid could influence the genetic integrity of fish by induced oxidative damage (Iturburu et al, 2018b).…”

Section: The Hazards and Acute Toxicity Of Imidacloprid In Cultured Fishmentioning

confidence: 99%

The new aspects of using some safe feed additives on alleviated imidacloprid toxicity in farmed fish: a review

Naiel

Shehata

Negm

et al. 2020

Reviews in Aquaculture

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Intensive fish culturing systems depend on provides optimal water quality conditions. Hence, the most important aquaculture practices are the removal of contamination elements related not only to the water quality parameters unacceptable for aquatic species but also to the undesirable effect on the health of fish and consumers. During the last three decades, common applications and production of pesticides have amplified progressively. Due to the excessive use of imidacloprid as a highly effective insecticide, elevated accumulation is expected in an aquatic environment. A large part of applied pesticides emitted into the environment and only a small portion of them reach the final biological target, where it caused several hazards, such as accumulation and toxicity to non‐target creatures. Plant‐derived secondary metabolites are getting great attention due to their safety and therapeutic functions. Also, several feed additives in animal diets can act as chemopreventive agents, which have the potential to decrease the toxicity risk of many pollutants and detoxification of activated metabolites. Understanding the internal action mechanisms of various safe feed additives could lead to the novel therapeutic approaches for acute and chronic pesticide toxicity. This review intends to summarize how safe feed additives alter or mitigate the toxic effects of imidacloprid in farmed fish.

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Section: The Hazards and Acute Toxicity Of Imidacloprid In Cultured Fishmentioning

confidence: 99%

The new aspects of using some safe feed additives on alleviated imidacloprid toxicity in farmed fish: a review

Naiel

Shehata

Negm

et al. 2020

Reviews in Aquaculture

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“…The test concentrations were determined by the concentration used for growing sugarcane, based on previous studies. [22]…”

Section: Experimental Designmentioning

confidence: 99%

Liver alterations inOreochromis niloticus(Pisces) induced by insecticide imidacloprid: Histopathology and heat shock proteinin situlocalization

Ansoar-Rodríguez

Christofoletti

Correia

et al. 2016

Journal of Environmental Science and Health, Part B

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Liver is very sensitive to environmental contaminants such as pesticides, it being the first target of toxicity of a substance. The objective of this study was to investigate the possible effects of the insecticide imidacloprid (IMI) on the liver of Oreochromis niloticus according concentrations used for growing sugarcane. A semi-quantitative analysis of histopathological alterations of IMI on liver was performed by light microscopy and cellular labeling of heat shock proteins (HSP70) by immunohistochemistry. The most common changes in liver at all concentrations of IMI were hydropic degeneration, pyknotic nuclei, and loss of cell limits. Steatosis and increased levels of HSP70 were detected in hepatocytes with the highest concentration of IMI. In conclusion, the tested concentrations of IMI induced histopathological changes in the liver of O. niloticus and active defence mechanisms to maintain the morphophysiological integrity of the liver. This insecticide has a toxicity potential for these fish, which is a non-target organism of its action.

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“…Reports showed the toxicological influences of IMID in different fish species [ 23 , 24 , 25 , 26 , 27 , 28 ]. Herein, it was found that after exposure to a sub-lethal IMID dose for 2 weeks, there were significantly increased SR% and decreased blood glucose, MDA levels, and IMID residual levels in the flesh and liver in all AC groups compared with the control group.…”

Section: Discussionmentioning

confidence: 99%

“…Although Tišler et al [ 22 ] showed that IMID was steady in the water and did not quickly undergo biodegradation in the ecosystems, the unsafe and unhygienic disposal of IMID will subsequently provoke serious toxic impacts on the exposed organisms [ 23 ]. In Nile tilapia, previous studies reported that IMID exposure induced genotoxicity [ 24 ], hematological changes [ 25 ], histopathological alterations [ 26 , 27 ], oxidative stress, and growth depression [ 28 ]. Furthermore, IMID induced neurotoxicity in zebrafish ( Danio rerio ) and rainbow trout ( Oncorhynchus mykiss ) [ 29 , 30 ], oxidative stress injury and genotoxicity in Streaked prochilod ( Prochilodus lineatus ) [ 31 ], spinal cord malformations of the Japanese rice fish ( Oryzias latipes ) [ 32 ], and genotoxicity and immunotoxicity in Chinese rare minnows ( Gobiocypris rarus ) [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Activated Charcoal on Growth, Immunity, Oxidative Stress Markers, and Physiological Responses of Nile Tilapia Exposed to Sub-Lethal Imidacloprid Toxicity

El-hameed¹,

Negm²,

Ismael³

et al. 2021

Animals

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The existing study was designed to assess the influences of dietary activated charcoal (AC) on the growth performance, immune responses, antioxidative status, and its mitigating roles against the physiological responses of Nile tilapia exposed a sub-lethal dose of a neonicotinoid agriculture pesticide, namely, as imidacloprid (IMID). Nile tilapia juveniles were fed on diets supplemented with graded AC levels as 0 (control), 5, 10, 15, and 20 g/kg diet for eight weeks. Growth, hemato-biochemical indices, and antioxidant and immune responses of fish in all groups were evaluated at the end of the feeding experiment. Afterward, fish in all experimental groups were subjected to a sub-lethal dose of IMID (0.0109 μg/L) for two weeks. Then, fish mortalities, stress indicators, and IMID residual levels in liver and flesh were examined. Results of the feeding experiment showed that total feed intake, weight gain, final body weights, and feed efficiency ratio were significantly increased in all AC groups compared with the control group. The survival rate was 100% in all experimental groups. No statistical differences were observed in the hematological picture of all experimental groups except the lymphocyte count, which was significantly increased in all AC groups compared to the control group. Total protein, albumin, globulin, nitric oxide levels, lysozyme, and respiratory burst activities were significantly increased in all AC groups. Serum alanine transaminase, aspartate transaminase, alkaline phosphatase activities, and malondialdehyde (MDA) levels were significantly decreased in all AC groups compared with the AC0 group. After exposure to a sub-lethal dose of IMID, survival rates were significantly elevated, and IMID residual levels in liver and flesh were significantly decreased in all AC groups than in the control group. Moreover, second-order polynomial regression showed that dietary supplementation with 14.30 g AC/kg diet resulted in the lowest blood glucose and serum MDA levels. Conclusively, we suggest dietary supplementation with 14.30 g AC/kg diet to modulate physiological responses of Nile tilapia to sub-lethal IMID toxicity.

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Genotoxic Potential of the Insecticide Imidacloprid in a Non-Target Organism (<i>Oreochromis niloticus</i>-Pisces)

Cited by 23 publications

References 38 publications

The new aspects of using some safe feed additives on alleviated imidacloprid toxicity in farmed fish: a review

The new aspects of using some safe feed additives on alleviated imidacloprid toxicity in farmed fish: a review

Liver alterations inOreochromis niloticus(Pisces) induced by insecticide imidacloprid: Histopathology and heat shock proteinin situlocalization

Effects of Activated Charcoal on Growth, Immunity, Oxidative Stress Markers, and Physiological Responses of Nile Tilapia Exposed to Sub-Lethal Imidacloprid Toxicity

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