Genotoxicity and ecotoxicity assays using the freshwater crustacean Daphnia magna and the larva of the aquatic midge Chironomus riparius to screen the ecological risks of nanoparticle exposure

Lee, Si-Won; Kim, Sung-Man; Choi, Jinhee

doi:10.1016/j.etap.2009.03.001

Cited by 143 publications

(80 citation statements)

References 41 publications

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“…The finding of a higher toxicity at lower exposure concentration for the micronsized CeO 2 in the chronic study may be explained provisionally by rapid aggregation at higher concentration, leading to lower effective doses at higher nominal concentrations. In contrast with these findings, a study by Lee et al [17] on D. magna assessing effects of CeO 2 (30 and 15 nm) at a concentration of 1 mg/L found significantly increased mortality compared with controls after 96 h exposure for the 15-nm particles, but not for 30-nm particles. In addition, genotoxicity was apparent in D. magna exposed to 1 mg/L of the 15-nm particles.…”

Section: Interspecies Uptake and Toxicity Of Ag And Ceo 2 Npsmentioning

confidence: 51%

“…96-h study, even at concentrations 10-fold higher (10 mg/L) than those shown to have effects on D. magna by Lee et al [17]. Although van Hoecke et al [18] measured a mean particle aggregate size of 400 nm by DLS, which is very similar to our results for the CeO 2 NPs, no such data are available from Lee et al [17], and a smaller mean aggregate size might explain the higher toxicity of the nano-CeO 2 in Lee et al [17]. Although we did not find short-term toxicity of CeO 2 NPs to D. magna, we …”

Section: Interspecies Uptake and Toxicity Of Ag And Ceo 2 Npsmentioning

confidence: 83%

“…Lee et al [17] showed significant mortality of D. magna after 96 h of exposure to 1 mg/L of 15 and 30 nm CeO 2 . Van Hoecke et al [18] exposed D. magna to higher concentrations of 14-, 20-, and 29-nm CeO 2 particles for 48 h, and found an LC50 of approximately 40 mg/L for the two smaller particles and 71 mg/ L for the 29-nm particles.…”

Section: Introductionmentioning

confidence: 98%

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Interspecies comparisons on the uptake and toxicity of silver and cerium dioxide nanoparticles

Gaiser

Fernandes

Jepson

et al. 2011

Enviro Toxic and Chemistry

167

111

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An increasing number and quantity of manufactured nanoparticles are entering the environment as the diversity of their applications increases, and this will lead to the exposure of both humans and wildlife. However, little is known regarding their potential health effects. We compared the potential biological effects of silver (Ag; nominally 35 and 600-1,600 nm) and cerium dioxide (CeO(2;) nominally <25 nm and 1-5 µm) particles in a range of cell (human hepatocyte and intestinal and fish hepatocyte) and animal (Daphnia magna, Cyprinus carpio) models to assess possible commonalities in toxicity across taxa. A variety of analytical techniques were employed to characterize the particles and investigate their biological uptake. Silver particles were more toxic than CeO(2) in all test systems, and an equivalent mass dose of Ag nanoparticles was more toxic than larger micro-sized material. Cellular uptake of all materials tested was shown in C3A hepatocytes and Caco-2 intestinal cells, and for Ag, into the intestine, liver, gallbladder, and gills of carp exposed via the water. The commonalities in toxicity of these particle types across diverse biological systems suggest that cross-species extrapolations may be possible for metal nanoparticle test development in the future. Our findings also suggest transport of particles through the gastrointestinal barrier, which is likely to be an important uptake route when assessing particle risk.

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Section: Interspecies Uptake and Toxicity Of Ag And Ceo 2 Npsmentioning

confidence: 51%

Section: Interspecies Uptake and Toxicity Of Ag And Ceo 2 Npsmentioning

confidence: 83%

See 1 more Smart Citation

Interspecies comparisons on the uptake and toxicity of silver and cerium dioxide nanoparticles

Gaiser

Fernandes

Jepson

et al. 2011

Enviro Toxic and Chemistry

167

111

View full text Add to dashboard Cite

show abstract

“…Moreover, information concerning genotoxicity, as well as, classical acute toxicity, on these species can be valuable for freshwater monitoring, taken into account of the importance of D. magna in the aquatic ecosystem. Lee et al (2009) analyzed the correlation between genoand eco-toxicity parameters to validate the ecotoxicological relevance of the response of DNA damage due to nanoparticle exposure in D. magna. DNA damage, particularly DNA strand breaks, was measured using a comet assay to evaluate whether the nanoparticles exerted genotoxicity on D. magna.…”

Section: Coliform and Escherichia Colimentioning

confidence: 99%

Toxicity evaluation of water samples collected near a hospital waste landfill through bioassays of genotoxicity piscine micronucleus test and comet assay in fish Astyanax and ecotoxicity Vibrio fischeri and Daphnia magna

et al. 2010

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In this study, we analyzed samples of water from a river and a lake located near a hospital waste landfill with respect to physico-chemical parameters and conducted bioassays of ecotoxicity using Vibrio fischeri and Daphnia magna, which are species commonly used to evaluate the water toxicity. We also evaluated damage to the genetic material of fish (Astyanax sp. B) that were exposed (96 h) to water from these two sites that were located near the tank ditch, using the alkaline comet assay and the piscine micronucleus test. Parameters including aluminum, manganese, biochemical oxygen demand, sulfide, conductivity, phenol, total coliforms and Escherichia coli counts, were above acceptable levels that have been established in environmental legislation. However, the toxicity bioassays that we carried out in Vibrio fischeri and Daphnia magna and the piscine micronucleus test in fish showed no immediate risk due to acute effects. Based on the results of the comet assay, however, it was possible to detect damage to genetic material in fish that were acutely exposed in the laboratory to water samples from the river and lake that are located near the trench septic tank. Thus, our results suggest that tests beyond those usually employed to test water toxicity, such as the comet assay we used in the fish, are required to assess the toxicity of water with greater accuracy.

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“…The mass production and wide use of metal NPs will inevitably increase their potential risks to the eco-environment [Lee et al, 2009]. In the processes of production and use, NPs are able to enter human body directly; additionally, NPs can be inhaled through the respiratory tract and accumulated in the food chain [Hanna et al, 2013] [Heng et al, 2010].…”

Section: Introductionmentioning

confidence: 99%

ZnO nanoparticles induced cytotoxicity on human pulmonary adenocarcinoma cell line LTEP-a-2

Wang

Meng

et al. 2015

Process Safety and Environmental Protection

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Please cite this article as: Wang, C., Wang, H., Lin, M., Hu, X.,ZnO nanoparticles induced cytotoxicity on human pulmonary adenocarcinoma cell line LTEP-a-2, Process Safety and Environment Protection (2014), http://dx.doi.org/10. 1016/j.psep.2014.05.007 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Genotoxicity and ecotoxicity assays using the freshwater crustacean Daphnia magna and the larva of the aquatic midge Chironomus riparius to screen the ecological risks of nanoparticle exposure

Cited by 143 publications

References 41 publications

Interspecies comparisons on the uptake and toxicity of silver and cerium dioxide nanoparticles

Interspecies comparisons on the uptake and toxicity of silver and cerium dioxide nanoparticles

Toxicity evaluation of water samples collected near a hospital waste landfill through bioassays of genotoxicity piscine micronucleus test and comet assay in fish Astyanax and ecotoxicity Vibrio fischeri and Daphnia magna

ZnO nanoparticles induced cytotoxicity on human pulmonary adenocarcinoma cell line LTEP-a-2

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